{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:36:29Z","timestamp":1790566589933,"version":"4.1.0"},"reference-count":31,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>\u2713Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovium with a predisposition for the appendicular skeleton. Rarely PVNS can arise from the spine, where this disorder usually presents with localized or radicular pain secondary to involvement of the posterior elements. The authors report the case of an 82-year-old woman who presented with long-standing neck pain and acute upper-extremity numbness and weakness. Computed tomography imaging revealed a mixed sclerotic and lucent lesion affecting the dens and right lateral mass of C-2. There was also a pathological fracture at the base of the dens with 8 mm of anterior dens displacement. Magnetic resonance imaging demonstrated a diffusely infiltrative process that was nonenhancing. Because of instability, the patient underwent transarticular screw fixation, and a biopsy of the lesion was also performed at this time. Histopathological analysis was consistent with a diagnosis of PVNS. To the authors' knowledge, this is the first report of PVNS involving the C-2 vertebra or causing a pathological fracture.<\/jats:p>","DOI":"10.3171\/spi-07\/08\/248","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T13:19:02Z","timestamp":1201180742000},"page":"248-253","source":"Crossref","is-referenced-by-count":22,"title":["Pigmented villonodular synovitis associated with pathological fracture of the odontoid and atlantoaxial instability"],"prefix":"10.3171","volume":"7","author":[{"given":"Michael A.","family":"Finn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd D.","family":"McCall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meic H.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0070248","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0046-8177(92)90340-9","article-title":"Diffuse and localized tenosynovial giant cell tumor and pigmented villonodular synovitis: a clinicopathologic and flow cytometric DNA analysis","volume":"23","author":"Abdul-Karim","year":"1992"},{"key":"b2-0070248","series-title":"Ann Rheum Dis","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1136\/ard.49.4.210","article-title":"Pigmented villonodular synovitis","volume":"49","author":"Bentley","year":"1990"},{"key":"b3-0070248","series-title":"Am J Surg Pathol","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/00000478-199702000-00004","article-title":"Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis)","volume":"21","author":"Bertoni","year":"1997"},{"key":"b4-0070248","series-title":"Brain Pathol","first-page":"263","article-title":"November 2000: 13 year old girl with back pain and leg weakness","volume":"11","author":"Bruecks","year":"2001"},{"key":"b5-0070248","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00004728-199601000-00020","article-title":"MRI of giant cell tumor of the tendon sheath in the cervical spine","volume":"20","author":"Bui-Mansfield","year":"1996"},{"key":"b6-0070248","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2106\/00004623-198264010-00022","article-title":"Pigmented villonodular synovitis of a lumbar vertebral facet joint","volume":"64","author":"Campbell","year":"1982"},{"key":"b7-0070248","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3171\/jns.1993.79.3.0456","article-title":"Pigmented villonodular synovitis of the spine. Case report","volume":"79","author":"Clark","year":"1993"},{"key":"b8-0070248","series-title":"Cancer Res","first-page":"3986","article-title":"Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis)","volume":"54","author":"Dal Cin","year":"1994"},{"key":"b9-0070248","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"942","DOI":"10.2106\/00004623-198769060-00026","article-title":"Pigmented villonodular synovitis","volume":"69","author":"Flandry","year":"1987"},{"key":"b10-0070248","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/S0046-8177(03)00250-8","article-title":"Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis","volume":"34","author":"Furlong","year":"2003"},{"key":"b11-0070248","series-title":"Spine","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1097\/00007632-199603010-00021","article-title":"Spinal pigmented villonodular synovitis: a case report","volume":"21","author":"Gezen","year":"1996"},{"key":"b12-0070248","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3171\/jns.1996.84.4.0592","article-title":"Pigmented villonodular synovitis of the spine: a clinical, radiological, and morphological study of 12 cases","volume":"84","author":"Giannini","year":"1996"},{"key":"b13-0070248","series-title":"Clin Orthop Relat Res","first-page":"335","article-title":"The pathogenesis and long-term end results of pigmented villonodular synovitis","volume":"114","author":"Granowitz","year":"1976"},{"key":"b14-0070248","series-title":"Clin Biomech (Bristol, Avon)","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0268-0033(02)00002-5","article-title":"Gait adaptations in patients with chronic posterior instability of the knee","volume":"17","author":"Hooper","year":"2002"},{"key":"b15-0070248","series-title":"Magn Reson Imaging Clin N Am","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S1064-9689(21)00621-8","article-title":"MR imaging of arthritides of the cervical spine","volume":"8","author":"Janssen","year":"2000"},{"key":"b16-0070248","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2106\/00004623-199072060-00022","article-title":"Pigmented villonodular synovitis in a vertebra. A case report","volume":"72","author":"Karnezis","year":"1990"},{"key":"b17-0070248","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1097\/00007632-199110000-00018","article-title":"Computed tomography and magnetic resonance imaging findings of pigmented villonodular synovitis of the spine","volume":"16","author":"Khoury","year":"1991"},{"key":"b18-0070248","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3171\/jns.1980.52.6.0846","article-title":"Villonodular synovitis in the spinal canal: case report","volume":"52","author":"Kleinman","year":"1980"},{"key":"b19-0070248","series-title":"Acta Pathol Jpn","first-page":"69","article-title":"Pigmented villonodular synovitis (giant cell tumor of the synovium) occurring in the vertebral column. Report of a case","volume":"42","author":"Kuwabara","year":"1992"},{"key":"b20-0070248","series-title":"Arch Pathol Lab Med","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.5858\/2000-124-1636-MGCTOS","article-title":"Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis)","volume":"124","author":"Layfield","year":"2000"},{"key":"b21-0070248","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3171\/jns.1992.77.6.0952","article-title":"Tenosynovial giant-cell tumor of the cervical spine. Case report","volume":"77","author":"Mahmood","year":"1992"},{"key":"b22-0070248","series-title":"Orthop Clin North Am","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ocl.2005.08.002","article-title":"Pigmented villonodular synovitis","volume":"37","author":"Ofluoglu","year":"2006"},{"key":"b23-0070248","series-title":"AJNR Am J Neuroradiol","first-page":"146","article-title":"MR imaging features of pigmented villonodular synovitis of the cervical spine","volume":"25","author":"Parmar","year":"2004"},{"key":"b24-0070248","series-title":"Arch Pathol Lab Med","first-page":"228","article-title":"Localized pigmented villonodular synovitis of the vertebral column","volume":"108","author":"Pulitzer","year":"1984"},{"key":"b25-0070248","series-title":"AJNR Am J Neuroradiol","first-page":"727","article-title":"CT myelography of extradural pigmented villonodular synovitis","volume":"8","author":"Retrum","year":"1987"},{"key":"b26-0070248","series-title":"Spine","doi-asserted-by":"publisher","first-page":"E213","DOI":"10.1097\/00007632-200105150-00022","article-title":"Pigmented villonodular synovitis of lumbar facet joint: a rare cause of nerve root entrapment","volume":"26","author":"Sampathkumar","year":"2001"},{"key":"b27-0070248","series-title":"Clin Orthop Relat Res","first-page":"243","article-title":"Pigmented villonodular synovitis. A retrospective review of affected large joints.","volume":"247","author":"Schwartz","year":"1989"},{"key":"b28-0070248","series-title":"AJNR Am J Neuroradiol","first-page":"164","article-title":"Pigmented villonodular synovitis of a lumbar facet joint","volume":"13","author":"Titelbaum","year":"1992"},{"key":"b29-0070248","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1002\/1097-0142(19860515)57:10<2030::AID-CNCR2820571025>3.0.CO;2-C","article-title":"Giant cell tumors of synovium (pigmented villonodular synovitis) involving the vertebral column","volume":"57","author":"Weidner","year":"1986"},{"key":"b30-0070248","series-title":"Soft Tissue Tumors","first-page":"1037","article-title":"Benign tumors and tumor-like lesions of synovial tissue","year":"2001"},{"key":"b31-0070248","series-title":"Am J Pathol","first-page":"799","article-title":"Experimental production of pigmented villonodular synovitis in dogs","volume":"30","author":"Young","year":"1954"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/7\/2\/article-p248.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/7\/2\/article-p248.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/7\/2\/article-p248.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T23:24:51Z","timestamp":1681601091000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/7\/2\/article-p248.xml"}},"subtitle":["Case report and review of the literature"],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":31,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/spi-07\/08\/248","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}