{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:18:56Z","timestamp":1761823136065},"reference-count":57,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> To assess clinical outcome and survival in patients with cervical vertebral spinal neoplasms after they have undergone anterior decompression and cervical plate stabilization (ACPS) by using either autologous bone graft or polymethylmethacrylate (PMMA) as the anterior load-bearing support structure.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> This was a retrospective case study composed of 30 patients harboring cervical spinal vertebral neoplasms who underwent anterior cervical decompression and (ACPS) within a 7-year period. Postoperative immobilization included treatment in a halo brace in two cases and in a hard cervical collar for the remaining patients. Postoperatively most patients underwent radio- and\/or chemotherapy. All patients except one benefited from a significantly improved quality of life with decreased pain and\/or improved neurological status. The mean Kaplan\u2014Meier survivoral estimate was 35.8 months (range 8 days\u201311.3 years, with 10 patients alive at most recent follow-up contact). Patients achieved long-term or lifelong mechanical stability in the cervical spine, and only one patient required a repeated posterior stabilization procedure. No hardware-related complications occurred. One patient died 8 days postoperatively of pneumonia. A nonsignificant difference in survival (p = 0.2164) was observed between patients harboring metastatic neoplasms (26.8 months) and those harboring lymphomatous and multiple myeloma neoplasms (54 months).<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> Favorable clinical outcome of both neurological symptoms and pain can be achieved using ACPS after surgery for neoplasms in the cervical vertebrae. Furthermore, long-term or lifelong cervical spine mechanical stability with bone fusion is achieved using this technique even when radiation therapy is delivered to the site of the bone graft.<\/jats:p>","DOI":"10.3171\/spi.1999.90.1.0027","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:48:06Z","timestamp":1241711286000},"page":"27-34","source":"Crossref","is-referenced-by-count":9,"title":["Anterior cervical plating for the treatment of neoplasms in the cervical vertebrae"],"prefix":"10.3171","volume":"90","author":[{"given":"Wolfhard","family":"Caspar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Pitzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Papavero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred H.","family":"Geisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Spine","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00007632-199103001-00008","article-title":"Treatment of cervical spine injuries with anterior plating. Indications, techniques, and results.","volume":"16","author":"Aebi","year":"1991"},{"key":"b2","series-title":"Surg Neurol","first-page":"162","article-title":"The use of anterior caspar plate fixation in acute cervical spine injury.","volume":"38","author":"Apfelbaum","year":"1992"},{"key":"b3","series-title":"J Neurosurg","first-page":"396","article-title":"Anterior cervical fusion by the Smith-Robinson approach.","volume":"29","author":"Aronson","year":"1968"},{"key":"b4","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/neurosurgery\/20.CN_suppl_1.253","article-title":"The management of soft disc protrusions using the Smith-Robinson approach.","volume":"20","author":"Aronson","year":"1973"},{"key":"b5","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1097\/00007632-199308000-00006","article-title":"Metastatic lesions of the cervical spine: a retrospective analysis of 20 cases.","volume":"18","author":"Atanasiu","year":"1993"},{"key":"b6","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"565","DOI":"10.2106\/00004623-196042040-00001","article-title":"Stabilization of cervical spine by anterior fusion.","volume":"42","author":"Bailey","year":"1960"},{"key":"b7","series-title":"Chir Organi Mov","first-page":"81","article-title":"Anterior surgery of the lower cervical spine.","volume":"77","author":"Bartolozzi","year":"1992"},{"key":"b8","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/BF01743989","article-title":"Radiologic long-term results after cervical vertebral interbody fusion with polymethyl methacrylate (PMMA).","volume":"12","author":"Boker","year":"1989"},{"key":"b9","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/BF01809274","article-title":"Anterior cervical discectomy and vertebral interbody fusion with hydroxy-apatite ceramic: preliminary results.","volume":"121","author":"Boker","year":"1993"},{"key":"b10","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0090-3019(97)00306-6","article-title":"Anterior cervical fusion using Caspar plating: analysis of results and review of the literature.","volume":"49","author":"Bose","year":"1998"},{"key":"b11","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1227\/00006123-198306000-00010","article-title":"Internal metal plate fixation combined with anterior interbody fusion in cases of cervical spine injury.","volume":"12","author":"Bremer","year":"1983"},{"key":"b12","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1097\/00007632-199210000-00002","article-title":"Repair of symptomatic pseudoarthrosis of anterior cervical fusion: posterior versus anterior repair.","volume":"17","author":"Brodsky","year":"1992"},{"key":"b13","series-title":"Clin Orthop Rel Res","first-page":"231","article-title":"A roentgenographic evaluation of frozen allografts versus autografts in anterior cervical spine fusions.","author":"Brown","year":"1976"},{"key":"b14","series-title":"Z Orthop","first-page":"809","article-title":"Die ventrale interkorporale stabilisierung mit der HWS-Trapez-Osteosyntheseplatte: Indikation, Technik, Ergebnisse.","volume":"119","author":"Caspar","year":"1981"},{"key":"b15","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1227\/00006123-198910000-00001","article-title":"Anterior cervical fusion and Caspar plate stabilization for cervical trauma.","volume":"25","author":"Caspar","year":"1989"},{"key":"b16","series-title":"Chir Organi Mov","first-page":"87","article-title":"The trapezial plate osteosynthesis: an advanced technology for anterior internal stabilization in cervical spine injuries and for the treatment of neck instability due to nontraumatic causes.","volume":"77","author":"Caspar","year":"1992"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3171\/jns.1958.15.6.0602","article-title":"The anterior approach for removal of ruptured cervical discs.","volume":"15","author":"Cloward","year":"1958"},{"key":"b18","series-title":"J Spinal Disord","first-page":"202","article-title":"Anterior cervical fusion: outcome analysis of patients fused with and without anterior cervical plates.","volume":"9","author":"Connolly","year":"1996"},{"key":"b19","series-title":"Spine","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/00007632-197703000-00002","article-title":"The role of methylmethacrylate in the stabilization and replacement of tumors of the cervical spine.","volume":"2","author":"Dunne","year":"1977"},{"key":"b20","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2106\/00004623-197961020-00015","article-title":"Anterior cervical vertebral body resection and bone-grafting for benign and malignant tumors. A survey under the auspices of the Cervical Spine Research Society.","volume":"61","author":"Fielding","year":"1979"},{"key":"b21","series-title":"Spine","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1097\/00007632-199804150-00013","article-title":"Reoperation in patients after anterior cervical plate stabilization in degenerative disease.","volume":"23","author":"Geisler","year":"1998"},{"key":"b22","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1227\/00006123-198912000-00003","article-title":"Anterior cervical fusion and osteosynthetic stabilization according to Caspar: a prospective study of 41 patients with fractures and\/or dislocations of the cervical spine.","volume":"25","author":"Goffin","year":"1989"},{"key":"b23","series-title":"Spine","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/00007632-199103001-00013","article-title":"Anterior plate fixation in spine tumor surgery. Indications, technique, and results.","volume":"16","author":"Hall","year":"1991"},{"key":"b24","series-title":"Spine","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/00007632-199305000-00014","article-title":"Short-term and long-term failures of anterior polymethylmethacrylate construct with esophageal perforation.","volume":"18","author":"Halligan","year":"1993"},{"key":"b25","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3171\/jns.1994.80.6.0963","article-title":"Cervical corpectomy and plate fixation for postlaminectomy kyphosis.","volume":"80","author":"Herman","year":"1994"},{"key":"b26","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/BF01405907","article-title":"Metal plate fixation after anterior fusion of unstable fracture dislocations of the cervical spine.","volume":"32","author":"Herrmann","year":"1975"},{"key":"b27","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3171\/jns.1995.82.2.0234","article-title":"One-stage internal fixation and anterior fusion in complex cervical spinal disorders.","volume":"82","author":"Johnston","year":"1995"},{"key":"b28","series-title":"J Spinal Disord","first-page":"429","article-title":"Anatomical and morphometric studies in posterior cervical spinal screw-plate systems.","volume":"7","author":"Jonsson","year":"1994"},{"key":"b29","series-title":"The Adult Spine: Principles and Practice.","article-title":"Differential diagnosis and surgical treatment of metastatic spine tumors","author":"Kostuik","year":"1997"},{"key":"b30","series-title":"Spine","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/00007632-198803000-00006","article-title":"Spinal stabilization of vertebral column tumors.","volume":"13","author":"Kostuik","year":"1988"},{"key":"b31","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1097\/00007632-199308000-00005","article-title":"Anterior cervical plate fixation with the titanium hollow screw plate system.","volume":"18","author":"Kostuik","year":"1993"},{"key":"b32","series-title":"Applied Survival Analysis.","author":"Le","year":"1997"},{"key":"b33","series-title":"Clin Orthop","first-page":"213","article-title":"Foreign body reaction to polymeric debris following total hop anthroplasty.","volume":"216","author":"Maguire","year":"1987"},{"key":"b34","series-title":"Epidemiology: An Introductory Text","author":"Mausner","year":"1985"},{"key":"b35","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.2106\/00004623-199512000-00001","article-title":"One-stage anterior cervical decompression and posterior stabilization: a study of one hundred patients with a minimum of two years of follow-up.","volume":"77","author":"McAfee","year":"1995"},{"key":"b36","series-title":"Int Orthop","first-page":"286","article-title":"Pseudarthrosis and delayed union after anterior cervical fusion.","volume":"17","author":"Mutoh","year":"1993"},{"key":"b37","series-title":"Int Orthop","first-page":"73","article-title":"Anterior cervical fusion with the Caspar instrumentation system.","volume":"17","author":"Naito","year":"1993"},{"key":"b38","series-title":"Spine","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1097\/00007632-199312000-00002","article-title":"The outcome of pseudarthrosis after cervical anterior fusion.","volume":"18","author":"Newman","year":"1993"},{"key":"b39","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"957","DOI":"10.3171\/jns.1996.84.6.0957","article-title":"Radiographic and clinical follow-up review of Caspar plates in 49 patients.","volume":"84","author":"Paramore","year":"1996"},{"key":"b40","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/BF01456113","article-title":"Total body replacement with iliac bone graft and metal plate stabilization in lower cervical spine.","volume":"85","author":"Pasztor","year":"1987"},{"key":"b41","series-title":"The Cervical Spine","first-page":"603","article-title":"Cervical spine metastases","author":"Rao","year":"1998"},{"key":"b42","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3171\/jns.1969.30.2.0127","article-title":"The results of anterior interbody fusion of the cervical spine: review of ninety-three consecutive cases.","volume":"30","author":"Riley","year":"1969"},{"key":"b43","series-title":"Bull John Hop Hosp","first-page":"223","article-title":"Antero-lateral cervical disc removal and interbody fusion for cervical disc syndrome.","volume":"96","author":"Robinson","year":"1955"},{"key":"b44","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.2106\/00004623-196244080-00007","article-title":"The results of anterior interbody fusion of the cervical spine.","volume":"44","author":"Robinson","year":"1962"},{"key":"b45","series-title":"Orthopade","first-page":"358","article-title":"[Pathology of spinal tumors].","volume":"16","author":"Roessner","year":"1987"},{"key":"b46","series-title":"Unfallchirug","first-page":"457","article-title":"[Spinal metastasis-induced pathological fractures of the spine].","volume":"93","author":"Schwarzenbach","year":"1990"},{"key":"b47","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3171\/jns.1967.27.3.0274","article-title":"The use of acrylic plastic for vertebral body replacement or fixation in metastatic disease of the spine.","volume":"27","author":"Scoville","year":"1967"},{"key":"b48","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/BF01401131","article-title":"Spondylectomy, microsurgical decompression and osteosynthesis in the treatment of complex disorders of the cervical spine.","volume":"124","author":"Seifert","year":"1993"},{"key":"b49","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3171\/jns.1996.84.2.0161","article-title":"Banked fibula and the locking anterior cervical plate in anterior cervical fusions following cervical discectomy.","volume":"84","author":"Shapiro","year":"1996"},{"key":"b50","series-title":"J Bone Joint Surg (Br)","first-page":"225","article-title":"Anterior cervical discectomy and fusion. A clinical and biomechanical study with eight-year follow-up.","volume":"51","author":"Simmons","year":"1969"},{"key":"b51","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1097\/00007632-199015100-00018","article-title":"Anterior cervical plate fixation with the titanium hollow screw plate system: a preliminary report.","volume":"15","author":"Suh","year":"1990"},{"key":"b52","series-title":"The Practice of Neurosurgery.","first-page":"1303","article-title":"Tumors of the spine: diagnosis and management","author":"Sundaresan","year":"1996"},{"key":"b53","series-title":"Am Surg","first-page":"704","article-title":"Management of metastatic tumors to the spine using simple plate fixation.","volume":"61","author":"Timlin","year":"1995"},{"key":"b54","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1227\/00006123-198806010-00006","article-title":"Anterior cervical fusion with the Caspar instrumentation system.","volume":"22","author":"Tippits","year":"1988"},{"key":"b55","series-title":"Arch Orthop Trauma Surg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00448086","article-title":"Cloward's anterior fusion in the treatment of cervical spinal traumatic injury and degeneration.","volume":"94","author":"Tunturi","year":"1979"},{"key":"b56","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"525","DOI":"10.2106\/00004623-197355030-00008","article-title":"Relief of pain by anterior cervical-spine fusion for spondylosis: a report of sixty-five patients.","volume":"55","author":"White","year":"1973"},{"key":"b57","series-title":"Spine","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1097\/00007632-199107000-00006","article-title":"The use of freeze-dried allograft bone for anterior cervical fusions.","volume":"16","author":"Zdeblick","year":"1991"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/90\/1\/article-p27.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/90\/1\/article-p27.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/90\/1\/article-p27.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:33:49Z","timestamp":1681605229000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/90\/1\/article-p27.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":57,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/spi.1999.90.1.0027","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}