{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T10:40:56Z","timestamp":1772275256840,"version":"3.50.1"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Brown tumors (osteoclastomas) are histologically benign lesions that are caused by primary or secondary hyperparathyroidism. Secondary hyperparathyroidism is a frequent complication of chronic renal failure. Skeletal brown tumors are relatively uncommon, and brown tumors that involve the spine are considered very rare. The authors present the case of a 37-year-old woman with systemic lupus erythematosus and hemodialysis-dependent anuric renal failure, in whom spinal cord compression developed due to a brown tumor and pathological fracture at T-9. The patient underwent transthoracic decompressive surgery and spinal reconstruction in which cadaveric femoral allograft and instrumentation were used. Brown tumors of the vertebral column require surgical treatment if medical therapy and parathyroidectomy fail to halt their progression or if acute neurological deterioration occurs. In patients with renal failure bone healing is delayed and there is an increased risk that healing will fail because the metabolic derangements can result in severe osteoporosis. Surgical reconstruction of the spine may require the use of augmentation with instrumentation and aggressive treatment of hyperparathyroidism to achieve successful outcomes.<\/jats:p>","DOI":"10.3171\/spi.1999.90.2.0242","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:46:08Z","timestamp":1241711168000},"page":"242-246","source":"Crossref","is-referenced-by-count":10,"title":["Chronic renal failure causing brown tumors and myelopathy"],"prefix":"10.3171","volume":"90","author":[{"given":"Igor","family":"Fineman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Patrick","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier-Luigi","family":"Di-Patre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvinder","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Spine","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1097\/00007632-199306000-00023","article-title":"Brown tumor of the cervical spine.","volume":"18","author":"Barlow","year":"1993"},{"key":"b2","series-title":"Am J Med","first-page":"545","article-title":"Brown tumor in secondary hyperparathyroidism causing acute paraplegia.","volume":"81","author":"Bohlman","year":"1996"},{"key":"b3","series-title":"Nephron","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000189286","article-title":"Long-term effects of intravenous 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replacement: material and techniques.","volume":"20","author":"Johnson","year":"1998"},{"key":"b8","series-title":"Clin Nucl Med","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/00003072-199407000-00016","article-title":"Multiple brown tumors in unsuspected primary hyperparathyroidism mimicking metastatic disease on radiograph and bone scan.","volume":"19","author":"Joyce","year":"1994"},{"key":"b9","series-title":"Medicine","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/00005792-196909000-00001","article-title":"Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure: analysis of 195 patients with observations on the effects of chronic dialysis, kidney transplantation and subtotal parathyroidectomy.","volume":"48","author":"Katz","year":"1969"},{"key":"b10","series-title":"Clin Nephrol","first-page":"92","article-title":"Long-term outcome following total parathyroidectomy in patients with end-stage renal 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