{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:25:33Z","timestamp":1759775133632},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> Polymethylmethacrylate (PMMA) has long been used in the stabilization and reconstruction of traumatic and pathological fractures of the spine. Recently, hydroxyapatite (HA), an osteoconductive, biocompatible cement, has been used as an alternative to PMMA. In this study the authors compare the stabilizing effects of the HA product, BoneSource, with PMMA in an experimental compression fracture of L-1.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> Twenty T9\u2014L3 cadaveric spine specimens were mounted individually on a testing frame. Light-emitting diodes were placed on the neural arches as well as the base. Motion was tracked by two video cameras in response to applied loads of 0 to 6 Nm. The weight-drop technique was used to induce a reproducible compression fracture of T-11 after partially coring out the vertebra. Load testing was performed on the intact spine, postfracture, after unilateral transpedicular vertebroplasty with 7 to 10 ml of PMMA or HA, and after flexion\u2014extension fatiguing to 5000 cycles at \u00b1 3 Nm.<\/jats:p>\n<jats:p content-type=\"fine-print\">No significant difference between the HA- and PMMA cemented\u2014fixated spines was demonstrated in flexion, extension, left lateral bending, or right and left axial rotation. The only difference between the two cements was encountered before and after fatiguing in right lateral bending (p \u2264 0.05).<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> The results of this study suggest that the same angular rigidity can be achieved using either HA or PMMA. This is of particular interest because HA is osteoconductive, undergoes remodeling, and is not exothermic.<\/jats:p>","DOI":"10.3171\/spi.2001.95.2.0215","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:51:25Z","timestamp":1241711485000},"page":"215-220","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of the biomechanics of hydroxyapatite and polymethylmethacrylate vertebroplasty in a cadaveric spinal compression fracture model"],"prefix":"10.3171","volume":"95","author":[{"given":"Patrick W.","family":"Hitchon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Goel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Drake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Taggard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Rogge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Torner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3171\/jns.1996.85.2.0211","article-title":"Single-stage posterior vertebrectomy and replacement combined with posterior instrumentation for spinal metastasis.","volume":"85","author":"Akeyson","year":"1996"},{"key":"b2","series-title":"J Spinal Disord","first-page":"439","article-title":"Corpectomy and stabilization with methylmethacrylate in patients with metastatic disease of the spine: a technical note.","volume":"8","author":"Alleyne","year":"1995"},{"key":"b3","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1097\/00007632-200107150-00007","article-title":"The biomechanics of vertebroplasty: the effect of cement volume on mechanical behavior.","volume":"26","author":"Belkoff","year":"2001"},{"key":"b4","series-title":"J Biomed Mater Res","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/(SICI)1097-4636(19970605)35:3<273::AID-JBM1>3.0.CO;2-E","article-title":"Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement.","volume":"35","author":"Cherng","year":"1997"},{"key":"b5","series-title":"Facial Plast Surg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-2008-1064591","article-title":"Synthetic biomaterials in facial plastic and reconstructive surgery.","volume":"9","author":"Costantino","year":"1993"},{"key":"b6","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1148\/radiology.200.2.8685351","article-title":"Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up.","volume":"200","author":"Cotten","year":"1996"},{"key":"b7","series-title":"Bone","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/S8756-3282(99)00127-1","article-title":"Temperature elevation caused by bone cement polymerization during vertebroplasty.","volume":"25","author":"Deramond","year":"1999"},{"key":"b8","series-title":"Techniques in Spinal Fusion and Stabilization.","first-page":"147","article-title":"Methyl methacrylate in spinal stabilization","author":"Duff","year":"1995"},{"key":"b9","series-title":"Scand J Plast Reconstr Surg","first-page":"261","article-title":"Assessment of bone viability after heat trauma. 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