{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:47:11Z","timestamp":1788403631191,"version":"build-2803163510"},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic> The authors conducted a study to evaluate the results of a unique surgical procedure for treating primary lumbar stenosis in patients with achondroplasia, based on its distorted anatomical dimensions.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic> A consecutive single-center series of 36 achondroplastic dwarfs with symptomatic lumbar stenosis underwent dynamic lumbar myelography to determine the most stenotic lumbar segment. This level was surgically decompressed by selective widening of the lumbar interapophyseolaminar diameter; laminectomy was not performed.<\/jats:p>\n<jats:p content-type=\"fine-print\">The L2\u20133 level was decompressed in 97% of the cases and the L1\u20132 and L3\u20134 levels in 58 and 61%, respectively. Lower lumbar levels were rarely affected by stenosis. Stenosis typically did not occur at the level of the lamina, where the pseudoscalloping of the vertebral body compensates for the spinal narrowing, obviating the need for laminectomy. Complete relief of symptoms was demonstrated in 25 (71.4%) of 35 patients. Tolerable disease remained in eight patients (22.9%) postoperatively. In two cases (5.7%) surgery resulted in no benefit. One case was lost to follow up. The presence of a lumbar epidural hematoma complicated one procedure.<\/jats:p>\n<jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic> In this series the interapophyseolaminar decompression was demonstrated to be an effective and safe procedure for the treatment of symptomatic stenosis in achondroplasia. The upper lumbar segments, particularly the L2\u20133 level, were most frequently involved. Dynamic lumbar myelography proved mandatory in demonstrating the symptomatic level.<\/jats:p>","DOI":"10.3171\/spi.2002.96.3.0292","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:53:27Z","timestamp":1241711607000},"page":"292-297","source":"Crossref","is-referenced-by-count":18,"title":["Surgical treatment of lumbar stenosis in achondroplasia"],"prefix":"10.3171","volume":"96","author":[{"given":"Ralph T. W. M.","family":"Thomeer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Marc C.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Radiol Clin North Am","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S0033-8389(22)02295-3","article-title":"A practical radiologic approach to skeletal dysplasias in infancy.","volume":"25","author":"Dutton","year":"1987"},{"key":"b2","series-title":"Am J Hum Genet","first-page":"454","article-title":"Mortality in achondroplasia.","volume":"41","author":"Hecht","year":"1987"},{"key":"b3","series-title":"Clin Pediatr","first-page":"793","article-title":"Some observations on the roles of achondroplastic dwarfs through history.","volume":"2","author":"Johnston","year":"1963"},{"key":"b4","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/ng0394-318","article-title":"A gene for achondroplasia-hypochondroplasia maps to chromosome 4p.","volume":"6","author":"Le Merrer","year":"1994"},{"key":"b5","series-title":"Teratology","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/tera.1420330103","article-title":"Studies of human achondroplasia: oxidative metabolism in tissue culture cells.","volume":"33","author":"Mackler","year":"1986"},{"key":"b6","series-title":"Teratology","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/tera.1420400605","article-title":"Human achondroplasia: defective mitochondrial oxidative energy metabolism may produce the pathophysiology.","volume":"40","author":"Mackler","year":"1989"},{"key":"b7","series-title":"Ann Hum Genet","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1469-1809.1970.tb01648.x","article-title":"Achondroplasia\u2014a genetic and statistical survey.","volume":"33","author":"Murdoch","year":"1970"},{"key":"b8","series-title":"J Med Genet","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1136\/jmg.16.2.140","article-title":"Achondroplasia and hypochondroplasia. Comments on frequency, mutation rate, and radiological features in skull and spine.","volume":"16","author":"Oberklaid","year":"1979"},{"key":"b9","series-title":"Bull Soc Anthropol","first-page":"296","article-title":"Sur la malformation achondroplastique et le Dieu Phtah.","volume":"1","author":"Parrot","year":"1878"},{"key":"b10","series-title":"Clin Orthop","first-page":"18","article-title":"Achondroplastic and hypochondroplastic dwarfism.","author":"Scott","year":"1976"},{"key":"b11","article-title":"Achondroplasia: management of neurological complications.","author":"Thomeer","year":"1982"},{"key":"b12","series-title":"Exp Med Surg","first-page":"108","article-title":"The fate of the achondroplastic dwarf. Neurological complications of achondroplasia.","volume":"20","author":"Vogl","year":"1962"},{"key":"b13","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1086\/302000","article-title":"Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome.","volume":"63","author":"Wilkin","year":"1998"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/96\/3\/article-p292.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/96\/3\/article-p292.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/96\/3\/article-p292.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T20:54:09Z","timestamp":1681592049000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/96\/3\/article-p292.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":13,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/spi.2002.96.3.0292","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}