{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:19:18Z","timestamp":1761823158205},"reference-count":50,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 There is a growing body of evidence in the literature suggesting that cavernous malformations of the central nervous system may develop after neuraxis irradiation. The authors discuss the case of a 17-year-old man who presented with progressive back pain and myelopathy 13 years after undergoing craniospinal irradiation for a posterior fossa medulloblastoma. Spinal magnetic resonance (MR) imaging, performed at the time of his initial presentation with a medulloblastoma, demonstrated no evidence of a malformation. Imaging studies and evaluation of cerebrospinal fluid revealed no evidence of recurrence or dissemination. Spinal MR imaging demonstrated an extensive lesion in the thoracic spine with an associated syrinx suggestive of a cavernous malformation. A thoracic laminectomy was performed and the malformation was successfully resected. Pathological examination confirmed the diagnosis. The patient did well after surgery and was ambulating without assistance 6 weeks later. To the best of the authors' knowledge, this is the second reported case in the literature and the first in the young adult age group suggesting the de novo development of cavernous malformations in the spinal cord after radiotherapy. An increased awareness of these lesions and close follow-up examination are recommended in this setting.<\/jats:p>","DOI":"10.3171\/spi.2003.98.1.0068","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:59:32Z","timestamp":1241711972000},"page":"68-72","source":"Crossref","is-referenced-by-count":7,"title":["Intramedullary spinal cavernous malformation following spinal irradiation"],"prefix":"10.3171","volume":"98","author":[{"given":"Prithvi","family":"Narayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0090-3019(00)00218-4","article-title":"De novo lesions in familial form of cerebral cavernous malformations: clinical and MR features in 29 non-Hispanic families.","volume":"53","author":"Brunereau","year":"2000"},{"key":"b2","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/0090-3019(95)80088-X","article-title":"Intramedullary cavernous angiomas of the spinal cord: report of six cases.","volume":"43","author":"Cantore","year":"1995"},{"key":"b3","series-title":"J Neurosurg","first-page":"354","article-title":"Cryptic vascular malformations in children: presentation, radiology, treatment and outcome in 36 consecutive patients.","volume":"78","author":"Ciricillo","year":"1993"},{"key":"b4","series-title":"Neurochirurgie","first-page":"263","article-title":"[Familial forms of intracranial cavernous hemangiomas. 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