{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:04:02Z","timestamp":1791054242467,"version":"4.1.0"},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7]]},"abstract":"Object.<\/jats:italic> The authors compared fusion rates in transforaminal lumbar interbody fusion (TLIFs) when using either autograft or bone morphogenetic protein (BMP) placed in the interbody space.<\/jats:p>\nMethods.<\/jats:italic> Between September 2002 and December 2003, the authors performed 44 TLIF operations. Follow-up data were available for 40 patients. Of the 40 procedures, 19 involved cages filled with iliac crest autograft (Group 1) and 21 involved cages filled with a medium kit of recombinant human (rh) BMP-2 (Group 2). In all Group 2 patients, one BMP sponge was placed anterior to the cage and another was placed within the cage. In 12 of the Group 2 patients, iliac crest autograft was placed posterior to the BMP-filled cage (Group 2A). In the remaining nine Group 2 patients, only local autograft was placed posterior to the BMP-filled cage (Group 2B). Assessment of fusion was performed using dynamic radiography at 3-month intervals. Outcomes were assessed using the Prolo Scale, and iliac crest donor site pain was measured using a Visual Analog Scale (VAS).<\/jats:p>\nThe mean follow-up period was 9 months (range 3\u201318 months). In Group 1 patients, one pseudarthrosis was detected. In Group 2 patients, dynamic radiography demonstrated solid fusion in all patients except one in Group 2B. Fiftyeight percent of patients in whom iliac crest autograft was used complained of donor site pain 6 months after surgery (5 of 10 points on the VAS). Symptomatic foraminal bone formation was not observed in any Group 2 patient.<\/jats:p>\nConclusions.<\/jats:italic> The use of rhBMP-2 is safe in TLIFs when the sponges are placed away from the dura mater, and BMP promotes a more rapid fusion than iliac crest autograft alone. The use of rhBMP-2 in combination with local autograft is an excellent option for promoting solid fusion with TLIF, and it eliminates the possibility of iliac donor site pain.<\/jats:p>","DOI":"10.3171\/spi.2004.1.1.0019","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T16:01:59Z","timestamp":1241712119000},"page":"19-23","source":"Crossref","is-referenced-by-count":125,"title":["Contribution of recombinant human bone morphogenetic protein\u20142 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report"],"prefix":"10.3171","volume":"1","author":[{"given":"Praveen V.","family":"Mummaneni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis W.","family":"Haid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald E.","family":"Rodts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199505000-00012"},{"key":"b2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00024720-200304000-00001","volume":"16","author":"Burkus JK","year":"2003","journal-title":"J Spinal Disord"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1051624"},{"key":"b4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00586-003-0548-5","volume":"12","author":"Hee HT","year":"2003","journal-title":"Eur Spine J"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200103010-00023"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1097\/00024720-200310000-00006"},{"issue":"3","key":"b7","volume":"16","author":"Lanman TH","year":"2004","journal-title":"Neurosurg Focus"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.3171\/spi.2002.97.4.0464"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1097\/00024720-200202000-00005"},{"key":"b10","first-page":"227","volume-title":"Lumbar Interbody Fusion: Cages, Dowels, and Grafts.","author":"Mummaneni PV","year":"2003"},{"issue":"13","key":"b11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00029679-200306300-00001","volume":"25","author":"Mummaneni PV","year":"2003","journal-title":"Contemp Neurosurg"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200103000-00022"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000103493.25162.18"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.88.2.0255"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1097\/00002517-200104000-00002"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/1\/1\/article-p19.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/1\/1\/article-p19.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T23:36:19Z","timestamp":1604705779000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/1\/1\/article-p19.xml"}},"subtitle":["Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004"],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":15,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/spi.2004.1.1.0019","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}