{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:25:31Z","timestamp":1789748731668,"version":"4.0.1"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p content-type=\"fine-print\"><jats:italic>Object.<\/jats:italic>Serotonin or 5-hydroxytryptamine (5-HT) is a chemical mediator associated with nucleus pulposus\u2014induced radiculopathy. Inhibition of 5-HT receptors may potentially alleviate symptoms in patients with lumbar disc herniation. This prospective randomized controlled study was performed to evaluate the efficacy of the 5-HT<jats:sub>2A<\/jats:sub>receptor inhibitor in the treatment of symptomatic lumbar disc herniation.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Methods.<\/jats:italic>Forty patients with sciatica due to L4\u20135 or L5\u2014S1 disc herniation were randomly allocated to treatment with the 5-HT<jats:sub>2A<\/jats:sub>inhibitor (sarpogrelate 300 mg\/day) or nonsteroidal antiinflammatory drugs (NSAIDs; diclofenac 75 mg\/day). Low-back pain, leg pain, and numbness were evaluated using a visual analog scale (VAS) before and after a 2-week course of treatment. The patients received only allocated medicine during the 2-week regimen and were thereafter allowed to choose any treatment options depending on their residual symptoms. One-year clinical outcomes were assessed based on the rates of additional medical interventions.<\/jats:p><jats:p content-type=\"fine-print\">The mean VAS score improvements in the 5-HT<jats:sub>2A<\/jats:sub>and NSAID groups were 33 and 46% for low-back pain, 32 and 32% for leg pain, and 35 and 22% for leg numbness, respectively. After the 2-week regimen, no additional medical interventions were required in 50% of 5-HT<jats:sub>2A<\/jats:sub>\u2014treated patients and 15% of those receiving NSAIDs. Epidural or nerve root block procedures were performed in 35% of the 5-HT<jats:sub>2A<\/jats:sub>group and 45% of the NSAID group. Surgery was required in 20% of the 5-HT<jats:sub>2A<\/jats:sub>group and 30% of the NSAID group patients.<\/jats:p><jats:p content-type=\"fine-print\"><jats:italic>Conclusions.<\/jats:italic>The current study provided evidence that the efficacy of the 5-HT<jats:sub>2A<\/jats:sub>inhibitor was comparable with that of NSAID therapy for lumbar disc herniation. The 5-HT<jats:sub>2A<\/jats:sub>inhibitor has the potential to alleviate symptoms in patients with lumbar disc herniation.<\/jats:p>","DOI":"10.3171\/spi.2005.2.4.0441","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T16:05:47Z","timestamp":1241712347000},"page":"441-446","source":"Crossref","is-referenced-by-count":27,"title":["New treatment of lumbar disc herniation involving 5-hydroxytryptamine2A receptor inhibitor: a randomized controlled 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