{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:11:06Z","timestamp":1784005866156,"version":"3.55.0"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"Supplement","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:sec><jats:title>Object<\/jats:title><jats:p>Gamma Knife surgery (GKS) is becoming a standard treatment for vestibular schwannoma (VS); it is ranked with microsurgery from the perspective of tumor control and audiofacial nerve function preservation. A new treatment technique that will improve the tumor shrinkage ratio, shorten the patient's recovery time, and even recover some cranial nerve function is described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Along with advances in the GKS system, the authors have developed magnetic resonance imaging sequences specific to particular treatments. These newly developed sequences provide much clearer visualization of the distribution of the cranial nerves, especially in the area from the cisterns to the internal acoustic meatus. Magnetic resonance images have been fused with computed tomography scans to facilitate better delineation of the anatomical relationships. These dose-planning images allow for a higher isodose line (80%) inside the tumor. The aim is to shrink the tumor and not just to control it. To date 130 patients have been treated with GKS in conjunction with this new technique. Of the 130, 91 patients were observed for more than 12 months. The tumor shrinkage rate was 65.9% (76% for patients with &gt; 24 months of follow up), the facial nerve preservation rate was 98.9%, the hearing preservation rate was 92.3%, and four (4%) of 91 patients recovered hearing function. Transient tumor enlargement was observed in most cases, but no severe complications were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Although these results are preliminary, they would appear to represent a potential breakthrough in the treatment of VS. Longer follow-up periods and additional cases will firmly establish this method as an absolute treatment option for patients with a VS.<\/jats:p><\/jats:sec>","DOI":"10.3171\/sup.2006.105.7.5","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T07:24:52Z","timestamp":1542353092000},"page":"5-11","source":"Crossref","is-referenced-by-count":15,"title":["Current treatment strategy for vestibular schwannoma: image-guided robotic microradiosurgery"],"prefix":"10.3171","volume":"105","author":[{"given":"Motohiro","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Chernov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Yomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokatsu","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kintomo","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Regis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"B1","series-title":"J Neurosurg 102 (Suppl)","first-page":"87","article-title":"Gamma Knife surgery for vestibular schwannoma: 10-year experience of 195 cases","author":"Chung","year":"2005"},{"key":"B2","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.ijrobp.2005.10.024","article-title":"Long-term outcome of stereotactic radiosurgery (SRS) in patients with acoustic neuromas","volume":"64","author":"Combs","year":"2006"},{"key":"B3","series-title":"Neurochirurgie","first-page":"350","article-title":"Preserving hearing function after Gamma Knife radiosurgery for unilateral vestibular schwannoma","volume":"50","author":"Gabert","year":"2004"},{"key":"B4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3171\/jns.2005.102.1.0010","article-title":"Long-term outcomes in patients with vestibular schwannomas treated using Gamma Knife surgery: 10-year follow up","volume":"102","author":"Hasegawa","year":"2005"},{"key":"B5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1227\/01.NEU.0000166542.00512.84","article-title":"Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years","volume":"57","author":"Hasegawa","year":"2005"},{"key":"B6","series-title":"Nippon Rinsho","first-page":"677","article-title":"[Gamma Knife surgery]","volume":"62","author":"Hayashi","year":"2004"},{"key":"B7","series-title":"Eur J Radiol","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0720-048X(98)00026-6","article-title":"The value of T2(*)-weighted MR images for the diagnosis of acoustic neuromas","volume":"30","author":"Held","year":"1999"},{"key":"B8","series-title":"J Neurosurg","first-page":"195","article-title":"Radiosurgery of vestibular schwannomas: summary of experience in 829 cases","volume":"102 (Suppl)","author":"Lunsford","year":"2005"},{"key":"B9","series-title":"No Shinkei Geka","first-page":"681","article-title":"[Surgical technique for vestibular schwannoma]","volume":"34","author":"Maruyama","year":"2006"},{"key":"B10","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.ijrobp.2005.10.030","article-title":"Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery","volume":"64","author":"Massager","year":"2006"},{"key":"B11","series-title":"Neurosurgery","first-page":"927","article-title":"Vestibular schwannomas: clinical results and quality of life after microsurgery or Gamma Knife radiosurgery","volume":"56","author":"Myrseth","year":"2005"},{"key":"B12","series-title":"AJNR Am J Neuroradiol","first-page":"1179","article-title":"MR cisternography of the cerebellopontine angle: comparison of three-dimensional fast asymmetrical spin-echo and three-dimensional constructive interference in the steady-state sequences","volume":"22","author":"Naganawa","year":"2001"},{"key":"B13","series-title":"AJNR Am J Neuroradiol","first-page":"1540","article-title":"Serial follow-up MR imaging after Gamma Knife radiosurgery for vestibular schwannoma","volume":"21","author":"Nakamura","year":"2000"},{"key":"B14","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/cncr.21190","article-title":"Hearing preservation after Gamma Knife stereotactic radiosurgery of vestibular schwannoma","volume":"104","author":"Paek","year":"2005"},{"key":"B15","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1227\/01.NEU.0000194833.66593.8B","article-title":"Management of vestibular schwannomas that enlarge after stereotactic radiosurgery: treatment recommendations based on a 15 year experience","volume":"58","author":"Pollock","year":"2006"},{"key":"B16","series-title":"J Neurosurg 97 (Suppl)","first-page":"588","article-title":"Impact of the model C and Automatic Positioning System on Gamma Knife radiosurgery: an evaluation in vestibular schwannomas","author":"Regis","year":"2002"},{"key":"B17","series-title":"Neurochirurgie","first-page":"270","article-title":"Stereotactic mapping for radiosurgical treatment of vestibular schwannomas","volume":"50","author":"Regis","year":"2004"},{"key":"B18","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1136\/jnnp.74.11.1536","article-title":"Gamma Knife stereotactic radiosurgery for unilateral acoustic neuromas","volume":"74","author":"Rowe","year":"2003"},{"key":"B19","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/00004728-199903000-00010","article-title":"Contrast-enhanced CISS MRI of vestibular schwannomas: phantom and clinical studies","volume":"23","author":"Shigematsu","year":"1999"},{"key":"B20","series-title":"Neurochirurgie","first-page":"338","article-title":"Injury of the lacrimal component of the nervus intermedius function after radiosurgery versus microsurgery","volume":"50","author":"Tamura","year":"2004"},{"key":"B21","series-title":"J Neurosurg","first-page":"25","article-title":"A comparison of the Gamma Knife model C and the automatic positioning system with Leksell model B","volume":"102 (Suppl)","author":"Tlachacova","year":"2005"},{"key":"B22","series-title":"J Neurosurg","first-page":"204","article-title":"Increased preservation of functional hearing after Gamma Knife surgery for vestibular schwannoma","volume":"102 (Suppl)","author":"van Eck","year":"2005"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/105\/Supplement\/article-p5.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/105\/Supplement\/article-p5.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/105\/Supplement\/article-p5.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T09:44:34Z","timestamp":1709977474000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/105\/Supplement\/article-p5.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":22,"journal-issue":{"issue":"Supplement"},"URL":"https:\/\/doi.org\/10.3171\/sup.2006.105.7.5","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}