{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:30:08Z","timestamp":1772109008234,"version":"3.50.1"},"reference-count":54,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The removal of mesial temporal structures, namely amygdalohippocampectomy, is the most efficient surgical procedure for the treatment of epilepsy. However, disconnection of the epileptogenic zones, as in temporal lobotomy or, for different purposes, hemispherotomy, have shown equivalent results with less morbidity. Thus, authors of the present study began performing selective amygdalohippocampotomy in cases of refractory mesial temporal lobe epilepsy (TLE) to treat mesial temporal lobe sclerosis (MTLS).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Method<\/jats:title>\n<jats:p>The authors conducted a retrospective analysis of all cases of amygdalohippocampotomy collected in a database between November 2007 and March 2011.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Since 2007, 21 patients (14 males and 7 females), ages 20\u201358 years (mean 41 years), all with TLE due to MTLS, were treated with selective ablation of the lateral amygdala plus perihippocampal disconnection (anterior one-half to two-thirds in dominant hemisphere), the left side in 11 cases and the right in 10. In 20 patients the follow-up was 2 or more years (range 24\u201344 months, average 32 months). Clinical outcome for epilepsy 2 years after surgery (20 patients) was good\/very good in 19 patients (95%) with an Engel Class I (15 patients [75%]) or II outcome (4 patients [20%]) and bad in 1 patient (5%) with an Engel Class IV outcome (extratemporal focus and later reoperation).<\/jats:p>\n<jats:p>Surgical morbidity included hemiparesis (capsular hypertensive hemorrhage 24 hours after surgery, 1 patient), verbal memory worsening (2 patients), and quadrantanopia (permanent in 2 patients, transient in 1). Late psychiatric depression developed in 3 cases. Operative time was reduced by about 30 minutes (15%) on average with this technique.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Amygdalohippocampotomy is as effective as amygdalohippocampectomy to treat MTLS and is a potentially safer, time-saving procedure.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2013.1.jns12727","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T15:27:24Z","timestamp":1361546844000},"page":"1107-1113","source":"Crossref","is-referenced-by-count":8,"title":["Amygdalohippocampotomy: surgical technique and clinical results"],"prefix":"10.3171","volume":"118","author":[{"given":"Antonio","family":"Gon\u00e7alves-Ferreira","sequence":"first","affiliation":[{"name":"Department of Neurosurgery;"}]},{"given":"Alexandre Rainha","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery;"}]},{"given":"Manuel","family":"Herculano-Carvalho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery;"}]},{"given":"Jose","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuropathology Laboratory;"}]},{"given":"Carla","family":"Bentes","sequence":"additional","affiliation":[{"name":"Department of Neurology, EEG Laboratory; and"}]},{"given":"Ana Rita","family":"Peralta","sequence":"additional","affiliation":[{"name":"Department of Neurology, EEG Laboratory; and"}]},{"given":"Carlos","family":"Morgado","sequence":"additional","affiliation":[{"name":"Department of Neurological Imaging, Unit of Epilepsy Surgery, Department of Neurosciences, University Hospital Santa Maria, Lisbon, Portugal"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[]}],"member":"1754","reference":[{"key":"b1-jns12727","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00006123-199707000-00004","article-title":"Surgical and neurological complications in a series of 708 epilepsy surgery procedures","volume":"41","author":"Behrens","year":"1997"},{"key":"b2-jns12727","series-title":"Brain","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1093\/brain\/awg034","article-title":"Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala and parahippocampal region","volume":"126","author":"Bernasconi","year":"2003"},{"key":"b3-jns12727","series-title":"Surg Forum","first-page":"431","article-title":"Treatment of generalized seizures by cerebral commissurotomy","volume":"14","author":"Bogen","year":"1963"},{"issue":"4 Suppl 2","key":"b4-jns12727","series-title":"Neurosurgery","first-page":"ONS279","article-title":"Microsurgical approaches to the medial temporal region: an anatomical study","volume":"59","author":"Campero","year":"2006"},{"key":"b5-jns12727","series-title":"Neurochirurgie","first-page":"297","article-title":"[Temporal disconnection as an alternative treatment for intractable temporal lobe epilepsy: techniques, complications and results.]","volume":"54","author":"Chabard\u00e8s","year":"2008"},{"issue":"4 Suppl 2","key":"b6-jns12727","series-title":"Neurosurgery","first-page":"ONS228","article-title":"Meyer's loop and the optic radiations in the transsylvian approach to the mediobasal temporal lobe","volume":"59","author":"Choi","year":"2006"},{"key":"b7-jns12727","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3171\/jns.2006.104.4.513","article-title":"Long-term outcome of epilepsy surgery among 399 patients with nonlesional seizure foci including mesial temporal lobe sclerosis","volume":"104","author":"Cohen-Gadol","year":"2006"},{"key":"b8-jns12727","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3171\/2011.12.JNS111256","article-title":"Supracerebellar transtentorial approach\u2014resection of the tentorium instead of an opening\u2014to provide broad exposure of the mediobasal temporal lobe: anatomical aspects and surgical applications. Clinical article","volume":"116","author":"de Oliveira","year":"2012"},{"issue":"3 Suppl","key":"b9-jns12727","series-title":"Epilepsia","first-page":"99","article-title":"Hemispherotomy: a new procedure for central disconnection","volume":"33","author":"Delalande","year":"1992"},{"key":"b10-jns12727","series-title":"The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI","author":"Duvernoy","year":"2005"},{"key":"b11-jns12727","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3171\/jns.1993.79.2.0256","article-title":"Microsurgical anatomy of the hippocampal arteries","volume":"79","author":"Erdem","year":"1993"},{"key":"b12-jns12727","series-title":"Stereotact Funct Neurosurg","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000100313","article-title":"Selective amygdalohippocampectomy: which route is the best?","volume":"63","author":"Gon\u00e7alves-Ferreira","year":"1994"},{"key":"b13-jns12727","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1227\/00006123-199501000-00004","article-title":"Reports by patients and their families of memory change after left anterior temporal lobectomy: relationship to degree of hippocampal sclerosis","volume":"36","author":"Hermann","year":"1995"},{"key":"b14-jns12727","series-title":"Neurosurgery","first-page":"50","article-title":"Subtemporal amygdalohippocampectomy for treating medically intractable temporal lobe epilepsy","volume":"33","author":"Hori","year":"1993"},{"key":"b15-jns12727","series-title":"Textbook of Epilepsy Surgery","first-page":"1223","article-title":"Mesial temporal lobectomy: post-surgical seizure frequency","author":"Jehi","year":"2008"},{"key":"b16-jns12727","series-title":"Textbook of Epilepsy Surgery","first-page":"1254","article-title":"Psychiatric outcome of epilepsy surgery","author":"Kanner","year":"2008"},{"key":"b17-jns12727","series-title":"Physiol Rev","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1152\/physrev.1990.70.2.453","article-title":"Anatomic organization and physiology of the limbic cortex","volume":"70","author":"Lopes da Silva","year":"1990"},{"key":"b18-jns12727","series-title":"Textbook of Epilepsy Surgery","first-page":"249","article-title":"Mesial temporal sclerosis","author":"L\u00fcders","year":"2008"},{"key":"b19-jns12727","series-title":"Am Surg","first-page":"265","article-title":"Interhemispheric commissurotomy as an alternative to hemispherectomy for control of intractable seizures","volume":"36","author":"Luessenhop","year":"1970"},{"key":"b20-jns12727","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3171\/2011.4.PEDS10454","article-title":"Temporoparietooccipital disconnection in children with intractable epilepsy. Clinical article","volume":"7","author":"Mohamed","year":"2011"},{"key":"b21-jns12727","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1227\/00006123-199107000-00009","article-title":"Extent of mesiobasal resection determines outcome after temporal lobectomy for intractable complex partial seizures","volume":"29","author":"Nayel","year":"1991"},{"key":"b22-jns12727","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1136\/jnnp.57.11.1375","article-title":"Psychiatric morbidity after surgery for epilepsy: short-term follow up of patients undergoing amygdalohippocampectomy","volume":"57","author":"Naylor","year":"1994"},{"key":"b23-jns12727","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jocn.2009.08.008","article-title":"Lateral temporal lobectomy with hippocampal disconnection as an alternative surgical technique for temporal lobe epilepsy","volume":"17","author":"Ng","year":"2010"},{"key":"b24-jns12727","series-title":"Temporal Lobe Epilepsy: A Colloquium Sponsored by the National Institute of Neurological Diseases and Blindness, National Institute of Health, Bethesda, Maryland, in Cooperation with the International League Against Epilepsy","first-page":"461","article-title":"The transventricular amygdalohippocampectomy in temporal lobe epilepsy","author":"Niemeyer","year":"1958"},{"key":"b25-jns12727","series-title":"Neurosurg Clin N Am","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1042-3680(18)30584-9","article-title":"Approaches to epilepsy surgery","volume":"4","author":"Ojemann","year":"1993"},{"key":"b26-jns12727","series-title":"Surgical Treatment of the Epilepsies","first-page":"405","article-title":"Commentary: cortical resections","author":"Olivier","year":"1987"},{"key":"b27-jns12727","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3171\/jns.1996.85.6.1172","article-title":"Subtemporal transparahippocampal amygdalohippocampectomy for surgical treatment of mesial temporal lobe epilepsy. Technical note","volume":"85","author":"Park","year":"1996"},{"key":"b28-jns12727","series-title":"Epilepsy and The Functional Anatomy of the Human Brain","author":"Penfield","year":"1954"},{"key":"b29-jns12727","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1227\/01.NEU.0000140843.62311.24","article-title":"Anatomy of the anterior temporal lobe and the frontotemporal region demonstrated by fiber dissection","volume":"55","author":"Peuskens","year":"2004"},{"key":"b30-jns12727","series-title":"Epileptic Disord","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1684\/epd.2010.0302","article-title":"Long-term and late seizure outcome after surgery for temporal lobe epilepsy","volume":"12","author":"Pimentel","year":"2010"},{"key":"b31-jns12727","series-title":"Operative Techniques in Epilepsy Surgery","first-page":"187","article-title":"Radiosurgery","author":"R\u00e9gis","year":"2009"},{"key":"b32-jns12727","series-title":"Microsurgery of the Temporo-Medial Region","author":"Renella","year":"1990"},{"issue":"Suppl 1","key":"b33-jns12727","series-title":"Neurochirurgie","first-page":"1","article-title":"[Research and surgical treatment of the epilepsies.]","volume":"38","author":"Rougier","year":"1992"},{"issue":"4 Suppl","key":"b34-jns12727","series-title":"Neurosurgery","first-page":"219","article-title":"Three-dimensional relationships of the optic radiation","volume":"57","author":"Rubino","year":"2005"},{"key":"b35-jns12727","series-title":"Neurosurgery","first-page":"51","article-title":"Complications of epilepsy surgery after 654 procedures in Sweden, September 1990\u20131995: a multicenter study based on the Swedish National Epilepsy Surgery Register","volume":"49","author":"Rydenhag","year":"2001"},{"key":"b36-jns12727","series-title":"Textbook of Epilepsy Surgery","first-page":"1288","article-title":"Temporal lobe epilepsy surgery: surgical complications","author":"Sasaki-Adams","year":"2008"},{"key":"b37-jns12727","series-title":"Epilepsia","first-page":"1296","article-title":"Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review","volume":"49","author":"Schramm","year":"2008"},{"key":"b38-jns12727","series-title":"Neurosurgery","first-page":"509","article-title":"Hemispherical deafferentation: an alternative to functional hemispherectomy","volume":"36","author":"Schramm","year":"1995"},{"key":"b39-jns12727","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00701-010-0900-6","article-title":"Randomized controlled trial of 2.5-cm versus 3.5-cm mesial temporal resection in temporal lobe epilepsy\u2014Part 1: intent-to-treat analysis","volume":"153","author":"Schramm","year":"2011"},{"key":"b40-jns12727","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3171\/jns.2004.101.5.0739","article-title":"White matter fiber dissection of the optic radiations of the temporal lobe and implications for surgical approaches to the temporal horn","volume":"101","author":"Sincoff","year":"2004"},{"key":"b41-jns12727","series-title":"Adv Tech Stand Neurosurg","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/978-3-7091-0641-9_6","article-title":"Surgical anatomy of the temporal lobe for epilepsy surgery","volume":"28","author":"Sindou","year":"2003"},{"key":"b42-jns12727","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3171\/2011.12.JNS11791","article-title":"The paramedian supracerebellar-transtentorial approach to the entire length of the mediobasal temporal region: an anatomical and clinical study. Laboratory investigation","volume":"116","author":"T\u00fcre","year":"2012"},{"key":"b43-jns12727","series-title":"Functional Neurosurgery","first-page":"16","article-title":"Surgical anatomy of the temporal lobe","author":"Ulm","year":"2009"},{"key":"b44-jns12727","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1001\/archneurpsyc.1940.02280100042004","article-title":"Surgical division of commissural pathways in the corpus callosum","volume":"44","author":"Van Wagenen","year":"1940"},{"key":"b45-jns12727","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1528-1157.2000.tb00135.x","article-title":"Subacute electrical stimulation of the hippocampus blocks intractable temporal lobe seizures and paroxysmal EEG activities","volume":"41","author":"Velasco","year":"2000"},{"key":"b46-jns12727","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1227\/00006123-199511000-00018","article-title":"Peri-insular hemispherotomy: surgical principles and anatomy","volume":"37","author":"Villemure","year":"1995"},{"key":"b47-jns12727","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/ana.10323","article-title":"Longterm amygdalohippocampal stimulation for refractory temporal lobe epilepsy","volume":"52","author":"Vonck","year":"2002"},{"key":"b48-jns12727","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1097\/00006123-199909000-00028","article-title":"Microsurgical anatomy of the temporal lobe: part 1: mesial temporal lobe anatomy and its vascular relationships as applied to amygdalohippocampectomy","volume":"45","author":"Wen","year":"1999"},{"key":"b49-jns12727","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1056\/NEJM200108023450501","article-title":"A randomized, controlled trial of surgery for temporal-lobe epilepsy","volume":"345","author":"Wiebe","year":"2001"},{"key":"b50-jns12727","series-title":"Epilepsia","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.0013-9580.2004.09004.x","article-title":"ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"45","author":"Wieser","year":"2004"},{"key":"b51-jns12727","series-title":"Surg Neurol","first-page":"445","article-title":"Selective amygdalohippocampectomy as a surgical treatment of mediobasal limbic epilepsy","volume":"17","author":"Wieser","year":"1984"},{"key":"b52-jns12727","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1212\/WNL.25.12.1149","article-title":"Disconnection of the cerebral hemispheres. An alternative to hemispherectomy for the control of intractable seizures","volume":"25","author":"Wilson","year":"1975"},{"key":"b53-jns12727","series-title":"Adv Tech Stand Neurosurg","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-3-7091-7008-3_2","article-title":"Selective amygdalo-hippocampectomy. Operative anatomy and surgical technique","volume":"12","author":"Ya\u015fargil","year":"1985"},{"key":"b54-jns12727","series-title":"Neurosurg Clin N Am","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S1042-3680(18)30591-6","article-title":"Surgery and results of selective amygdala-hippocampectomy in one hundred patients with nonlesional limbic epilepsy","volume":"4","author":"Ya\u015fargil","year":"1993"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/118\/5\/article-p1107.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/118\/5\/article-p1107.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/118\/5\/article-p1107.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T18:02:57Z","timestamp":1660500177000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/118\/5\/article-p1107.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":54,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2013.1.jns12727","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}