{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:52:27Z","timestamp":1764827547686},"reference-count":0,"publisher":"Journal of Nepal Medical Association (JNMA)","issue":"212","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nepal Med Assoc"],"abstract":"<jats:p>Introduction: Chronic periodontitis is an infectious disease. Porphyromonas gingivalis is the major pathogen associated with it and can be found in all ecosystems in the oral cavity. The presence of this organism is highly correlated with preterm and low birth weight babies. So, this study aimed to assess vertical transmission of P.gingivalis from pregnant women to their new born.&#x0D;\nMethods: Forty six pregnant women with chronic periodontitis were recruited for this cross-sectional study. Whole unstimulated saliva was collected from them before delivery and from their new-borns within forty eight hours of birth. Quantification of P.gingivalis in the saliva samples was carried out by quantitative real time polymerase chain reaction. The obtained data were analysed by SPSS 16 program.&#x0D;\nResults: The results showed a significant correlation (P=0.002) between the number of P.gingivalis present in the mother\u2019s saliva with that of the new-borns\u2019 saliva. DNA copies of more than 5000\/\u03bcl of P.gingivalis was found in 20 (43.5%) maternal saliva and 21 (45.7%) in new-borns\u2019 saliva. Both Plaque index and Extent and Severity index showed no correlation (P&gt;0.05) with DNA copies of P.gingivalis in new-borns\u2019 saliva.&#x0D;\nConclusions: The DNA copies of P.gingivalis found in new-borns\u2019 saliva are in par with mother saliva, as the saliva sample obtained from new-borns\u2019 were within forty eight hours of birth, no other environmental factor can have a direct role in its transmission. Thus, it can be concluded that P.gingivalis is vertically transmitted from mother to child.<\/jats:p>","DOI":"10.31729\/jnma.3475","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T10:45:07Z","timestamp":1537958707000},"page":"781-786","source":"Crossref","is-referenced-by-count":7,"title":["Estimation of Transmission of Porphyromonas Gingivalis from Mother to Child through Saliva"],"prefix":"10.31729","volume":"56","author":[{"given":"Khushbu","family":"Adhikari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charanjeet Singh","family":"Saimbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birendra Prasad","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16919","published-online":{"date-parts":[[2018,8,31]]},"container-title":["Journal of Nepal Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/3475\/2781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/3475\/2781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T10:45:19Z","timestamp":1537958719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/view\/3475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":0,"journal-issue":{"issue":"212","published-online":{"date-parts":[[2018,8,31]]}},"URL":"https:\/\/doi.org\/10.31729\/jnma.3475","relation":{},"ISSN":["1815-672X","0028-2715"],"issn-type":[{"value":"1815-672X","type":"electronic"},{"value":"0028-2715","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,31]]}}}