{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T17:03:02Z","timestamp":1751821382584,"version":"3.40.5"},"reference-count":0,"publisher":"Journal of Nepal Medical Association (JNMA)","issue":"238","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nepal Med Assoc"],"abstract":"<jats:p>Hereditary vitamin D dependent rickets type II is a rare genetic disorder in children characterized by early onset of rickets and deranged biochemical parameters. Low serum calcium level, high alkaline phosphatase, high parathyroid hormone, and high values of 1,25-dihydroxy vitamin D are characteristic biochemical findings. We are reporting a rare case of Vitamin D Dependent Rickets and subsequent improvement after addition of cinacalcet. This is a case report of a 2.5-year-child with Hereditary Vitamin D Dependent Rickets type II receiving cinacalcet as adjunct to oral calcium and calcitriol. Oral cinacalcet (0.25mg\/kg\/day) was added to the regimen as an adjunct after treatment failure with high dose of oral calcium and calcitriol. A significant improvement in radiological findings and normal homeostasis of calcium, phosphate and parathyroid hormone was achieved after initiation of cinacalcet.<\/jats:p>","DOI":"10.31729\/jnma.6411","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T15:06:32Z","timestamp":1625497592000},"source":"Crossref","is-referenced-by-count":3,"title":["Hereditary Vitamin-D Dependent Rickets Type II: A Case Report"],"prefix":"10.31729","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-8062","authenticated-orcid":false,"given":"Neela","family":"Sunuwar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swotantra","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Twayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj","family":"Adhikari Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firoz","family":"Anjum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriti","family":"Kandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16919","published-online":{"date-parts":[[2021,6,30]]},"container-title":["Journal of Nepal Medical Association"],"original-title":[],"link":[{"URL":"http:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/6411\/3553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/6411\/3553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T15:06:32Z","timestamp":1625497592000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/view\/6411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":0,"journal-issue":{"issue":"238","published-online":{"date-parts":[[2021,6,30]]}},"URL":"https:\/\/doi.org\/10.31729\/jnma.6411","relation":{},"ISSN":["1815-672X","0028-2715"],"issn-type":[{"type":"electronic","value":"1815-672X"},{"type":"print","value":"0028-2715"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}