{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:30:07Z","timestamp":1790289007015,"version":"4.1.0"},"reference-count":0,"publisher":"Journal of Nepal Medical Association (JNMA)","issue":"249","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nepal Med Assoc"],"abstract":"<jats:p>Choriocarcinoma is a malignant trophoblastic tumour usually of placental origin. It is characterized by early metastasis to the brain and lungs. With early detection, it has a better prognosis with treatment. We report a case of 18 years female at 26 weeks of gestation in her third pregnancy who had a history of treatment for metastatic gestational trophoblastic neoplasm with chemotherapy and radiotherapy two years back. Therefore, she was managed as a case of recurrent choriocarcinoma with brain metastasis with chemotherapy (etoposide and cisplatin with etoposide, methotrexate, and dactinomycin) and was responsive. Her symptoms resolved and \u03b2-human chorionic gonadotropin dropped to normal value (&lt;2.39 mIU\/ml) which has shown that timely diagnosis and management can be vital for the successful treatment of brain metastasis.<\/jats:p>","DOI":"10.31729\/jnma.7081","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T17:36:50Z","timestamp":1652290610000},"page":"488-490","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent Metastatic Choriocarcinoma Responsive to Etoposide and  Cisplatin with Etoposide, Methotrexate, and Dactinomycin: A Case Report"],"prefix":"10.31729","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-5149","authenticated-orcid":false,"given":"Sunil Kumar","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Shahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Chandra","family":"Panthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16919","published-online":{"date-parts":[[2022,5,5]]},"container-title":["Journal of Nepal Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/7081\/4142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/7081\/4142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:55:58Z","timestamp":1656006958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/view\/7081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":0,"journal-issue":{"issue":"249","published-online":{"date-parts":[[2022,5,5]]}},"URL":"https:\/\/doi.org\/10.31729\/jnma.7081","relation":{},"ISSN":["1815-672X","0028-2715"],"issn-type":[{"value":"1815-672X","type":"electronic"},{"value":"0028-2715","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,5]]}}}