{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:09:27Z","timestamp":1789927767283,"version":"4.0.1"},"reference-count":0,"publisher":"Journal of Nepal Medical Association (JNMA)","issue":"290","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nepal Med Assoc"],"abstract":"<jats:p>Introduction: Neonatal jaundice is a common condition affecting 60% of term and 80% of preterm neonates within the first week of life. Phototherapy, though the standard treatment for neonatal hyperbilirubinemia, may cause complications such as hypocalcemia, a significant but lesser-known side effect. This study compared phototherapy-induced hypocalcemia in late preterm and term neonates with unconjugated hyperbilirubinemia, after 48 hours of phototherapy.\nMethods: This hospital-based descriptive cross-sectional study was conducted in the Neonatal Intensive Care Unit of a tertiary care Hospital from 16th August 2022 to 10th July 2023. A total of 150 neonates, both term and preterm,with hyperbilirubinemia requiring at least 48 hours of phototherapy were\u00a0enrolled. After ethical approval and informed consent, data were collected using a structured questionnaire and analyzed using SPSS version 23.\nResults: After 48 hours of phototherapy, calcium decreased in both groups. In term neonates, it decreased from 9.44\u00b10.59 to 8.57\u00b10.73 mg\/dL (mean change 0.87 mg\/ dL, 95% CI 0.77\u20130.97) and in preterm neonates from 9.10\u00b10.43 to 7.94\u00b10.79 mg\/ dL (mean change 1.16 mg\/dL, 95% CI 1.01\u20131.31). The between group difference was 0.29 mg\/dL (95% CI: 0.11\u20130.47), Cohen\u2019s d = 0.55. Hypocalcemia occurred in 19(21.30%) term and 21(34.40%) preterm neonates (RR 1.61, 95% CI 0.95\u20132.73; RD 13.1%, 95% CI-7.2% to 32.8%).\nConclusions: There is a reduction in serum calcium levels in both term and preterm neonates after phototherapy. While exploratory analyses suggested a higher risk of hypocalcemia in preterm neonates, subgroup comparisons were underpowered and should be interpreted cautiously.<\/jats:p>","DOI":"10.31729\/jnma.v63i290.9208","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:17:00Z","timestamp":1759162620000},"source":"Crossref","is-referenced-by-count":2,"title":["Phototherapy Induced Hypocalcemia in Term and Preterm Neonates with Hyperbilirubinemia: A Cross-Sectional Study"],"prefix":"10.31729","volume":"63","author":[{"given":"Drishti","family":"Poudel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Tamang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamuna","family":"Neupane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramchandra","family":"Bastola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagya","family":"Raj Sigdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Chand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabin","family":"Raj Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16919","published-online":{"date-parts":[[2025,9,28]]},"container-title":["Journal of Nepal Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/9208\/5415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/download\/9208\/5415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:27:48Z","timestamp":1759940868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jnma.com.np\/jnma\/index.php\/jnma\/article\/view\/9208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":0,"journal-issue":{"issue":"290","published-online":{"date-parts":[[2025,9,28]]}},"URL":"https:\/\/doi.org\/10.31729\/jnma.v63i290.9208","relation":{},"ISSN":["1815-672X","0028-2715"],"issn-type":[{"value":"1815-672X","type":"electronic"},{"value":"0028-2715","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,28]]}}}