{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:50:13Z","timestamp":1778550613289,"version":"3.51.4"},"reference-count":47,"publisher":"American Society of Neuroradiology (ASNR)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJNR Am J Neuroradiol"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.3174\/ajnr.a3015","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:17:47Z","timestamp":1331857067000},"page":"1591-1595","source":"Crossref","is-referenced-by-count":39,"title":["Severity of Leukoaraiosis in Large Vessel Atherosclerotic Disease"],"prefix":"10.3174","volume":"33","author":[{"given":"A.","family":"Chutinet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Biffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kanakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.L.","family":"Furie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.S.","family":"Rost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1756","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"2018042011152676000_33.8.1591.1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.501932"},{"key":"2018042011152676000_33.8.1591.2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.521906"},{"key":"2018042011152676000_33.8.1591.3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a18823"},{"key":"2018042011152676000_33.8.1591.4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320209"},{"key":"2018042011152676000_33.8.1591.5","doi-asserted-by":"publisher","DOI":"10.1159\/000069414"},{"key":"2018042011152676000_33.8.1591.6","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1161\/01.STR.21.6.890","article-title":"Relation of leukoaraiosis to lesion type in stroke patients","volume":"21","author":"Hijdra","year":"1990","journal-title":"Stroke"},{"key":"2018042011152676000_33.8.1591.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fc279a"},{"key":"2018042011152676000_33.8.1591.8","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91144-B"},{"key":"2018042011152676000_33.8.1591.9","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250025008"},{"key":"2018042011152676000_33.8.1591.10","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1007\/s004150050586","article-title":"Carotid atherosclerosis and cerebral white matter lesions in a population based magnetic resonance imaging study","volume":"247","author":"de Leeuw","year":"2000","journal-title":"J Neurol"},{"key":"2018042011152676000_33.8.1591.11","doi-asserted-by":"publisher","DOI":"10.1159\/000064741"},{"key":"2018042011152676000_33.8.1591.12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-8-31"},{"key":"2018042011152676000_33.8.1591.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2010.07.008"},{"key":"2018042011152676000_33.8.1591.14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.563502"},{"key":"2018042011152676000_33.8.1591.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"2018042011152676000_33.8.1591.16","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X11399328"},{"key":"2018042011152676000_33.8.1591.17","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1212\/01.WNL.0000142966.22886.20","article-title":"White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage","volume":"63","author":"Smith","year":"2004","journal-title":"Neurology"},{"key":"2018042011152676000_33.8.1591.18","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000191403.95453.6a"},{"key":"2018042011152676000_33.8.1591.19","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000223613.57229.24"},{"key":"2018042011152676000_33.8.1591.20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1552-6569.2006.00069.x","article-title":"Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI","volume":"17","author":"Nandigam","year":"2007","journal-title":"J Neuroimaging"},{"key":"2018042011152676000_33.8.1591.21","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1212\/WNL.44.7.1246","article-title":"Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study","volume":"44","author":"Breteler","year":"1994","journal-title":"Neurology"},{"key":"2018042011152676000_33.8.1591.22","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.2.318"},{"key":"2018042011152676000_33.8.1591.23","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1274"},{"key":"2018042011152676000_33.8.1591.24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.1.67"},{"key":"2018042011152676000_33.8.1591.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000135226.53499.85"},{"key":"2018042011152676000_33.8.1591.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.05.007"},{"key":"2018042011152676000_33.8.1591.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01341.x"},{"key":"2018042011152676000_33.8.1591.28","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1212\/WNL.40.6.911","article-title":"Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter.","volume":"40","author":"Leifer","year":"1990","journal-title":"Neurology"},{"key":"2018042011152676000_33.8.1591.29","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.761"},{"key":"2018042011152676000_33.8.1591.30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1683"},{"key":"2018042011152676000_33.8.1591.31","first-page":"372","article-title":"Does tortuosity in cerebral arterioles impair down-autoregulation in hypertensives and elderly normotensives? A hypothesis and computer model.","volume":"37","author":"Moody","year":"1991","journal-title":"Clin Neurosurg"},{"key":"2018042011152676000_33.8.1591.32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00005072-199401000-00003","article-title":"Arteriolar tortuosity of the white matter in aging and hypertension: a microradiographic study","volume":"53","author":"Spangler","year":"1994","journal-title":"J Neuropathol Exp Neurol"},{"key":"2018042011152676000_33.8.1591.33","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.3.652"},{"key":"2018042011152676000_33.8.1591.34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000114088","article-title":"The human periventricular arterial blood supply and the anatomy of cerebral infarctions","volume":"5","author":"De Reuck","year":"1971","journal-title":"Eur Neurol"},{"key":"2018042011152676000_33.8.1591.35","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.STR.18.5.896","article-title":"Leukoencephalopathy in patients with ischemic stroke","volume":"18","author":"Bogousslavsky","year":"1987","journal-title":"Stroke"},{"key":"2018042011152676000_33.8.1591.36","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X444071"},{"key":"2018042011152676000_33.8.1591.37","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.12.2262"},{"key":"2018042011152676000_33.8.1591.38","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1212\/WNL.56.7.921","article-title":"Longitudinal study of blood pressure and white matter hyperintensities: the EVA MRI Cohort","volume":"56","author":"Dufouil","year":"2001","journal-title":"Neurology"},{"key":"2018042011152676000_33.8.1591.39","first-page":"93","article-title":"Pathology of small artery disease","volume":"62","author":"Ostrow","year":"1993","journal-title":"Adv Neurol"},{"key":"2018042011152676000_33.8.1591.40","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1212\/WNL.40.10.1540","article-title":"Chinese-white differences in the distribution of occlusive cerebrovascular disease","volume":"40","author":"Feldmann","year":"1990","journal-title":"Neurology"},{"key":"2018042011152676000_33.8.1591.41","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1161\/01.STR.27.11.1974","article-title":"Race and sex differences in the distribution of cerebral atherosclerosis","volume":"27","author":"Wityk","year":"1996","journal-title":"Stroke"},{"key":"2018042011152676000_33.8.1591.42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/01.STR.24.2.206","article-title":"Distribution of atherosclerosis and risk factors in atherothrombotic occlusion","volume":"24","author":"Yasaka","year":"1993","journal-title":"Stroke"},{"key":"2018042011152676000_33.8.1591.43","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1212\/WNL.50.3.812","article-title":"Intracranial stenosis in Chinese patients with acute stroke","volume":"50","author":"Wong","year":"1998","journal-title":"Neurology"},{"key":"2018042011152676000_33.8.1591.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(02)00264-3"},{"key":"2018042011152676000_33.8.1591.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2005.08.026"},{"key":"2018042011152676000_33.8.1591.46","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1355"},{"key":"2018042011152676000_33.8.1591.47","first-page":"1012","article-title":"Intracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography","volume":"26","author":"Bash","year":"2005","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["American Journal of Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3174\/ajnr.A3015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T18:21:31Z","timestamp":1524248491000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ajnr.org\/lookup\/doi\/10.3174\/ajnr.A3015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,9,10]]},"published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.3174\/ajnr.A3015"],"URL":"https:\/\/doi.org\/10.3174\/ajnr.a3015","relation":{},"ISSN":["0195-6108","1936-959X"],"issn-type":[{"value":"0195-6108","type":"print"},{"value":"1936-959X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]}}}