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Gastroenterology. 2020;159(1):81-95.","journal-title":"Gastroenterology"},{"key":"key20201106151843_B28","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.25822","article-title":"Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis","author":"Cao","year":"2020","unstructured":"28. Cao Y, Liu X, Xiong L, Cai K. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis. J Med Virol. 2020 Apr 3:10.1002\/jmv.25822. Review.","journal-title":"J Med Virol"},{"issue":"6","key":"key20201106151843_B29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jmv.25757","article-title":"COVID-19 patients\u2019 clinical characteristics, discharge rate, and fatality rate of meta-analysis","volume":"92","author":"Li","year":"2020","unstructured":"29. Li L, Huang T, Wang Y, Wang Z, Liang Y, Huang T, et al. 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