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Pediatria Ambulatorial: da teoria \u00e0 pr\u00e1tica. S\u00e3o Paulo: Atheneu; 2016. Se\u00e7\u00e3o 3. O dia a dia do Pediatra \u2013 o problema, a\u00e7\u00f5es b\u00e1sicas para o diagnostico e condu\u00e7\u00e3o do caso; p.185-188 [S\u00e9rie atualiza\u00e7\u00f5es pedi\u00e1tricas]."},{"key":"key20220802142058_B47","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1086\/317516","article-title":"External cooling in the management of fever","volume":"31","author":"Axelrod","year":"2000","unstructured":"47. Axelrod P. External cooling in the management of fever. Clin Infect Dis. 2000;31(Suppl 5):S224-9. Review.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"key20220802142058_B48","article-title":"Physical methods versus drug placebo or no treatment for managing fever in children","volume":"2003","author":"Meremikwu","year":"2003","unstructured":"48. Meremikwu M, Oyo-Ita A. Physical methods versus drug placebo or no treatment for managing fever in children. 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