{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:26Z","timestamp":1753890086198,"version":"3.41.2"},"reference-count":24,"publisher":"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,10]]},"DOI":"10.31744\/einstein_journal\/2025ao0964","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T14:53:48Z","timestamp":1741704828000},"source":"Crossref","is-referenced-by-count":0,"title":["Validation of an ultra-high performance liquid chromatography\/UV method to quantify busulfan in plasma: application to therapeutic drug monitoring"],"prefix":"10.31744","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-9434","authenticated-orcid":false,"given":"Laura Ben","family":"Olivo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8031-707X","authenticated-orcid":false,"given":"Gabriel Giron","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-5263","authenticated-orcid":false,"given":"Bruna Bernar","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8745-1430","authenticated-orcid":false,"given":"Jana\u00edna Aparecida Risczik Arruda","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-2802","authenticated-orcid":false,"given":"Bruna Martins","family":"Schweinberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6843-5689","authenticated-orcid":false,"given":"Raiza Lima do","family":"Carmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9495-6932","authenticated-orcid":false,"given":"Liane Esteves","family":"Daudt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-2991","authenticated-orcid":false,"given":"Teresa Dalla","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-0389","authenticated-orcid":false,"given":"Bibiana Verlindo de","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16942","reference":[{"issue":"10","key":"key20250311143350_B1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.drudis.2014.04.005","article-title":"Personalized busulfan and treosulfan conditioning for pediatric stem cell transplantation: the role of pharmacogenetics and pharmacokinetics","volume":"19","author":"ten Brink","year":"2014","unstructured":"1. ten Brink MH, Zwaveling J, Swen JJ, Bredius RG, Lankester AC, Guchelaar HJ. Personalized busulfan and treosulfan conditioning for pediatric stem cell transplantation: the role of pharmacogenetics and pharmacokinetics. Drug Discov Today. 2014;19(10):1572-86. Review.","journal-title":"Drug Discov Today"},{"issue":"53","key":"key20250311143350_B2","doi-asserted-by":"crossref","first-page":"90852","DOI":"10.18632\/oncotarget.20310","article-title":"GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study","volume":"8","author":"Ansari","year":"2017","unstructured":"2. Ansari M, Curtis PH, Uppugunduri CR, Rezgui MA, Nava T, Mlakar V, et al. GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study. Oncotarget. 2017;8(53):90852-67.","journal-title":"Oncotarget"},{"issue":"5","key":"key20250311143350_B3","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/FTD.0b013e31826051bb","article-title":"Predictive performance of a busulfan pharmacokinetic model in children and young adults","volume":"34","author":"Bartelink","year":"2012","unstructured":"3. Bartelink IH, van Kesteren C, Boelens JJ, Egberts TC, Bierings MB, Cuvelier GD, et al. Predictive performance of a busulfan pharmacokinetic model in children and young adults. Ther Drug Monit. 2012;34(5):574-83.","journal-title":"Ther Drug Monit"},{"issue":"8","key":"key20250311143350_B4","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.bbmt.2018.02.020","article-title":"Phase II Trial of High-Dose Gemcitabine\/Busulfan\/Melphalan with Autologous Stem Cell Transplantation for Primary Refractory or Poor-Risk Relapsed Hodgkin Lymphoma","volume":"24","author":"Nieto","year":"2018","unstructured":"4. Nieto Y, Thall PF, Ma J, Valdez BC, Ahmed S, Anderlini P, et al. Phase II Trial of High-Dose Gemcitabine\/Busulfan\/Melphalan with Autologous Stem Cell Transplantation for Primary Refractory or Poor-Risk Relapsed Hodgkin Lymphoma. Biol Blood Marrow Transplant. 2018;24(8):1602-9.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"key20250311143350_B5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.bbmt.2019.12.725","article-title":"Allogeneic Hemopoietic Stem Cell Transplants in Patients with Acute Myeloid Leukemia (AML) Prepared with Busulfan and Fludarabine (BUFLU) or Thiotepa, Busulfan, and Fludarabine (TBF): A Retrospective Study","volume":"26","author":"Sora","year":"2020","unstructured":"5. Sora F, Grazia CD, Chiusolo P, Raiola AM, Bregante S, Mordini N, et al. Allogeneic Hemopoietic Stem Cell Transplants in Patients with Acute Myeloid Leukemia (AML) Prepared with Busulfan and Fludarabine (BUFLU) or Thiotepa, Busulfan, and Fludarabine (TBF): A Retrospective Study. Biol Blood Marrow Transplant. 2020;26(4):698-703.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"6","key":"key20250311143350_B6","doi-asserted-by":"crossref","first-page":"490.e1","DOI":"10.1016\/j.jtct.2021.03.006","article-title":"Myeloablative Busulfan\/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Trial ANBL12P1","volume":"27","author":"Granger","year":"2021","unstructured":"6. Granger MM, Naranjo A, Bagatell R, DuBois SG, McCune JS, Tenney SC, et al. Myeloablative Busulfan\/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Trial ANBL12P1. Transplant Cell Ther. 2021;27(6):490.e1-8.","journal-title":"Transplant Cell Ther"},{"issue":"4","key":"key20250311143350_B7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1046\/j.1365-2125.2002.01555.x","article-title":"Pharmacokinetics of intravenous busulfan in children prior to stem cell transplantation","volume":"53","author":"Cremers","year":"2002","unstructured":"7. Cremers S, Schoemaker R, Bredius R, den Hartigh J, Ball L, Twiss I, et al. Pharmacokinetics of intravenous busulfan in children prior to stem cell transplantation. Br J Clin Pharmacol. 2002;53(4):386-9.","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"key20250311143350_B8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/FTD.0b013e31829dc940","article-title":"Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: can the strategy be improved?","volume":"36","author":"Buffery","year":"2014","unstructured":"8. Buffery PJ, Allen KM, Chin PK, Moore GA, Barclay ML, Begg EJ. Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: can the strategy be improved? Ther Drug Monit. 2014;36(1):86-92.","journal-title":"Ther Drug Monit"},{"issue":"11","key":"key20250311143350_B9","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.bbmt.2016.07.013","article-title":"Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee","volume":"22","author":"Palmer","year":"2016","unstructured":"9. Palmer J, McCune JS, Perales MA, Marks D, Bubalo J, Mohty M, et al. Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee. Biol Blood Marrow Transplant. 2016;22(11):1915-25.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"key20250311143350_B10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0378-4347(88)80034-3","article-title":"Determination of busulfan in human plasma by gas chromatography with electron-capture detection","volume":"425","author":"Chen","year":"1988","unstructured":"10. Chen TL, Grochow LB, Hurowitz LA, Brundrett RB. Determination of busulfan in human plasma by gas chromatography with electron-capture detection. J Chromatogr, Biomed Appl. 1988;425(2):303-9.","journal-title":"J Chromatogr, Biomed Appl"},{"issue":"1","key":"key20250311143350_B11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-4347(98)00019-X","article-title":"Quantification of busulfan in plasma by gas chromatography-mass spectrometry following derivatization with tetrafluorothiophenol","volume":"709","author":"Quernin","year":"1998","unstructured":"11. Quernin MH, Poonkuzhali B, Montes C, Krishnamoorthy R, Dennison D, Srivastava A, et al. Quantification of busulfan in plasma by gas chromatography-mass spectrometry following derivatization with tetrafluorothiophenol. J Chromatogr B Biomed Sci Appl. 1998;709(1):47-56.","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"98-105","key":"key20250311143350_B12","article-title":"Gas chromatographic-mass spectrometry method for the detection of busulphan and its metabolites in plasma and urine","volume":"913-914","author":"El-Serafi","year":"2013","unstructured":"12. El-Serafi I, Terelius Y, Twelkmeyer B, Hagbj\u00f6rk AL, Hassan Z, Hassan M. Gas chromatographic-mass spectrometry method for the detection of busulphan and its metabolites in plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;913-914:98-105.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key20250311143350_B13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0378-4347(00)84861-6","article-title":"Gas chromatographic determination of busulfan in plasma with electron-capture detection","volume":"277","author":"Hassan","year":"1983","unstructured":"13. Hassan M, Ehrsson H. Gas chromatographic determination of busulfan in plasma with electron-capture detection. J Chromatogr, Biomed Appl. 1983;277:374-80.","journal-title":"J Chromatogr, Biomed Appl"},{"issue":"2","key":"key20250311143350_B14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00685617","article-title":"Gas-chromatographic analysis of busulfan for therapeutic drug monitoring","volume":"32","author":"Embree","year":"1993","unstructured":"14. Embree L, Burns RB, Heggie JR, Phillips GL, Reece DE, Spinelli JJ, et al. Gas-chromatographic analysis of busulfan for therapeutic drug monitoring. Cancer Chemother Pharmacol. 1993;32(2):137-42.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"12","key":"key20250311143350_B15","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/rcm.1962","article-title":"Development of a rapid and specific assay for detection of busulfan in human plasma by high-performance liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"19","author":"dos Reis","year":"2005","unstructured":"15. dos Reis EO, Vianna-Jorge R, Suarez-Kurtz G, Lima EL, Azevedo DA. Development of a rapid and specific assay for detection of busulfan in human plasma by high-performance liquid chromatography\/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(12):1666-74.","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"2","key":"key20250311143350_B16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0378-4347(00)00167-5","article-title":"Rapid and sensitive high-performance liquid chromatographic method for busulfan assay in plasma","volume":"742","author":"Bleyzac","year":"2000","unstructured":"16. Bleyzac N, Barou P, Aulagner G. Rapid and sensitive high-performance liquid chromatographic method for busulfan assay in plasma. J Chromatogr B Biomed Sci Appl. 2000;742(2):427-32.","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"1-2","key":"key20250311143350_B17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0378-4347(01)00356-5","article-title":"Quantification of busulfan in plasma by liquid chromatography-ion spray mass spectrometry. Application to pharmacokinetic studies in children","volume":"763","author":"Quernin","year":"2001","unstructured":"17. Quernin MH, Duval M, Litalien C, Vilmer E, Aigrain EJ. Quantification of busulfan in plasma by liquid chromatography-ion spray mass spectrometry. Application to pharmacokinetic studies in children. J Chromatogr B Biomed Sci Appl. 2001;763(1-2):61-9.","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"2","key":"key20250311143350_B18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0378-4347(96)00520-8","article-title":"Validation of a high-performance liquid chromatographic assay method for pharmacokinetic evaluation of busulfan","volume":"692","author":"Heggie","year":"1997","unstructured":"18. Heggie JR, Wu M, Burns RB, Ng CS, Fung HC, Knight G, et al. Validation of a high-performance liquid chromatographic assay method for pharmacokinetic evaluation of busulfan. J Chromatogr B Biomed Sci Appl. 1997;692(2):437-44.","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"2","key":"key20250311143350_B19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00007691-199704000-00009","article-title":"Measurement of plasma busulfan concentration by high-performance liquid chromatography with ultraviolet detection","volume":"19","author":"Rifai","year":"1997","unstructured":"19. Rifai N, Sakamoto M, Lafi M, Guinan E. Measurement of plasma busulfan concentration by high-performance liquid chromatography with ultraviolet detection. Ther Drug Monit. 1997;19(2):169-74.","journal-title":"Ther Drug Monit"},{"issue":"1-2","key":"key20250311143350_B20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0378-4347(97)00419-2","article-title":"Stability-indicating high-performance liquid chromatographic assay of busulfan in aqueous and plasma samples","volume":"704","author":"Chow","year":"1997","unstructured":"20. Chow DS, Bhagwatwar HP, Phadungpojna S, Andersson BS. Stability-indicating high-performance liquid chromatographic assay of busulfan in aqueous and plasma samples. J Chromatogr B Biomed Sci Appl. 1997;704(1-2):277-88.","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"1","key":"key20250311143350_B21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-4347(99)00214-5","article-title":"Determination of busulfan in human plasma using high-performance liquid chromatography with pre-column derivatization and fluorescence detection","volume":"730","author":"Peris","year":"1999","unstructured":"21. Peris JE, Latorre JA, Castel V, Verdeguer A, Esteve S, Torres-Molina F. Determination of busulfan in human plasma using high-performance liquid chromatography with pre-column derivatization and fluorescence detection. J Chromatogr B Biomed Sci Appl. 1999;730(1):33-40.","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"7","key":"key20250311143350_B22","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1590\/S0100-40422012000700031","article-title":"Determina\u00e7\u00e3o de bussulfano em plasma atrav\u00e9s de cromatografia l\u00edquida de alta efici\u00eancia com detector de arranjo de diodos e derivatiza\u00e7\u00e3o com dietilditiocarbamato de s\u00f3dio","volume":"35","author":"Backes","year":"2012","unstructured":"22. Backes CF, Wagner SC, Morisso FD, Antunes MV, Linden R, Capra M. Determina\u00e7\u00e3o de bussulfano em plasma atrav\u00e9s de cromatografia l\u00edquida de alta efici\u00eancia com detector de arranjo de diodos e derivatiza\u00e7\u00e3o com dietilditiocarbamato de s\u00f3dio. Quim Nova. 2012;35(7):1468-73.","journal-title":"Quim Nova"},{"key":"key20250311143350_B23","author":"Brasil","year":"2012","unstructured":"23. Brasil. Minist\u00e9rio da Sa\u00fade. Ag\u00eancia Nacional De Vigil\u00e2ncia Sanit\u00e1ria. Resolu\u00e7\u00e3o da Diretoria Colegiada (RDC) No. 27, de 17 de maio de 2012. Disp\u00f5e sobre os requisitos m\u00ednimos para a valida\u00e7\u00e3o de m\u00e9todos bioanal\u00edticos empregados em estudos com fins de registro e p\u00f3s-registro de medicamentos. Bras\u00edlia (DF): Minist\u00e9rio da Sa\u00fade; 2012 [citado 2024 Set 27]. Dispon\u00edvel em: https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/anvisa\/2012\/rdc0027_17_05_2012.html","journal-title":"Resolu\u00e7\u00e3o da Diretoria Colegiada (RDC) No. 27, de 17 de maio de 2012. Disp\u00f5e sobre os requisitos m\u00ednimos para a valida\u00e7\u00e3o de m\u00e9todos bioanal\u00edticos empregados em estudos com fins de registro e p\u00f3s-registro de medicamentos"},{"issue":"6","key":"key20250311143350_B24","article-title":"Otimiza\u00e7\u00e3o de m\u00e9todo anal\u00edticoem HPLC-PDApara monitora\u00e7\u00e3o terap\u00eautica do bussulfano oral em pacientes transplantadosde c\u00e9lulas-tronco hematopoi\u00e9ticas","volume":"10","author":"Effting","year":"2021","unstructured":"24. Effting C, Oliveira FG, Mundim IM, Cruz AC, Rodrigues AR, Rodrigues CR, et al. Otimiza\u00e7\u00e3o de m\u00e9todo anal\u00edticoem HPLC-PDApara monitora\u00e7\u00e3o terap\u00eautica do bussulfano oral em pacientes transplantadosde c\u00e9lulas-tronco hematopoi\u00e9ticas. Soc Dev. 2021;10(6):E48110615864.","journal-title":"Soc Dev"}],"container-title":["einstein (S\u00e3o Paulo)"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T14:53:57Z","timestamp":1741704837000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.einstein.br\/article\/validation-of-an-ultra-high-performance-liquid-chromatography-uv-method-to-quantify-busulfan-in-plasma-application-to-therapeutic-drug-monitoring\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":24,"alternative-id":["10.31744\/einstein_journal\/2025AO0964"],"URL":"https:\/\/doi.org\/10.31744\/einstein_journal\/2025ao0964","relation":{},"ISSN":["1679-4508","2317-6385"],"issn-type":[{"type":"print","value":"1679-4508"},{"type":"electronic","value":"2317-6385"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"eAO0964"}}