{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:46:29Z","timestamp":1791913589449,"version":"4.3.4"},"reference-count":25,"publisher":"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","issue":"spe1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,9]]},"DOI":"10.31744\/einstein_journal\/2026ae2239","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:57:41Z","timestamp":1791910661000},"source":"Crossref","is-referenced-by-count":0,"title":["Probabilistic clinical studies and deterministic physiology: building a Monte Carlo bridge with the \"Frank\" project"],"prefix":"10.31744","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-8712","authenticated-orcid":false,"given":"Felipe Coelho","family":"Argolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2786-0199","authenticated-orcid":false,"given":"Arthur Vasconcelos de Luna","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4252-4668","authenticated-orcid":false,"given":"Larrie Rabelo","family":"Laporte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-9896","authenticated-orcid":false,"given":"Guilherme Moreira","family":"Magnavita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-1366","authenticated-orcid":false,"given":"Lu\u00eds Cl\u00e1udio Lemos","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16942","reference":[{"issue":"4","key":"key20261013165735_B1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0002-9343(83)90433-3","article-title":"The nature of illness and diagnosis","volume":"75","author":"Fessel","year":"1983","unstructured":"1 Fessel WJ. The nature of illness and diagnosis. Am J Med. 1983;75(4):555-60.","journal-title":"Am J Med"},{"key":"key20261013165735_B2","volume-title":"Oxford Textbook of Movement Disorders","author":"Stern","year":"2013","unstructured":"2 Stern G. Overview and Historical Perspective. In: Burn D, editor. Oxford Textbook of Movement Disorders. Oxford University Press; 2013."},{"issue":"3","key":"key20261013165735_B3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/jep.12035","article-title":"Physiological mechanisms and epidemiological research","volume":"19","author":"Bluhm","year":"2013","unstructured":"3 Bluhm R. Physiological mechanisms and epidemiological research. J Eval Clin Pract. 2013;19(3):422-6.","journal-title":"J Eval Clin Pract"},{"issue":"1","key":"key20261013165735_B4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0895-4356(93)90005-L","article-title":"The use of statistical methods in the analysis of clinical studies","volume":"46","author":"Salsburg","year":"1993","unstructured":"4 Salsburg D. The use of statistical methods in the analysis of clinical studies. J Clin Epidemiol. 1993;46(1):17-27.","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"key20261013165735_B5","first-page":"197","article-title":"Galen's (130-201 AD) Conceptions of the Heart","volume":"56","author":"Karamanou","year":"2015","unstructured":"5 Karamanou M, Stefanadis C, Tsoucalas G, Laios K, Androutsos G. Galen's (130-201 AD) Conceptions of the Heart. Hell J Cardiol. 2015;56(3):197-200.","journal-title":"Hell J Cardiol"},{"issue":"3","key":"key20261013165735_B6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/jappl.1984.57.3.635","article-title":"Stephen Hales: neglected respiratory physiologist","volume":"57","author":"West","year":"1984","unstructured":"6 West JB. Stephen Hales: neglected respiratory physiologist. J Appl Physiol. 1984;57(3):635-9.","journal-title":"J Appl Physiol"},{"issue":"3","key":"key20261013165735_B7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0022-2828(90)91460-O","article-title":"The basic shape of the arterial pulse. First treatise: mathematical analysis. 1899","volume":"22","author":"Frank","year":"1990","unstructured":"7 Frank O. The basic shape of the arterial pulse. First treatise: mathematical analysis. 1899. J Mol Cell Cardiol. 1990;22(3):255-77.","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"key20261013165735_B8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02368323","article-title":"Identification of the three-element windkessel model incorporating a pressure-dependent compliance","volume":"23","author":"Cappello","year":"1995","unstructured":"8 Cappello A, Gnudi G, Lamberti C. Identification of the three-element windkessel model incorporating a pressure-dependent compliance. Ann Biomed Eng. 1995;23(2):164-77.","journal-title":"Ann Biomed Eng"},{"issue":"2","key":"key20261013165735_B9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11517-008-0359-2","article-title":"The arterial Windkessel","volume":"47","author":"Westerhof","year":"2009","unstructured":"9 Westerhof N, Lankhaar JW, Westerhof BE. The arterial Windkessel. Med Biol Eng Comput. 2009;47(2):131-41.","journal-title":"Med Biol Eng Comput"},{"key":"key20261013165735_B10","volume-title":"StatPearls","author":"Basnet","year":"2025","unstructured":"10 Basnet A, Rout P. Calculating FICK Cardiac Output and Input. StatPearls. Treasure Island (FL): StatPearls Publishing; 2025."},{"issue":"5","key":"key20261013165735_B11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/107385849800400520","article-title":"Claude Bernard and the Constancy of the Internal Environment","volume":"4","author":"Gross","year":"1998","unstructured":"11 Gross CG. Claude Bernard and the Constancy of the Internal Environment. Neuroscientist. 1998;4(5):380-5.","journal-title":"Neuroscientist"},{"issue":"7864","key":"key20261013165735_B12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-021-03618-9","article-title":"Magnetic sensitivity of cryptochrome 4 from a migratory songbird","volume":"594","author":"Xu","year":"2021","unstructured":"12 Xu J, Jarocha LE, Zollitsch T, Konowalczyk M, Henbest KB, Richert S, et al. Magnetic sensitivity of cryptochrome 4 from a migratory songbird. Nature. 2021;594(7864):535-40.","journal-title":"Nature"},{"issue":"2","key":"key20261013165735_B13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/scientificamerican0290-42","article-title":"Chaos and fractals in human physiology","volume":"262","author":"Goldberger","year":"1990","unstructured":"13 Goldberger AL, Rigney DR, West BJ. Chaos and fractals in human physiology. Sci Am. 1990;262(2):42-9.","journal-title":"Sci Am"},{"issue":"2","key":"key20261013165735_B14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0008-6363(98)00251-X","article-title":"Chaos in the cardiovascular system: an update","volume":"40","author":"Wagner","year":"1998","unstructured":"14 Wagner CD, Persson PB. Chaos in the cardiovascular system: an update. Cardiovasc Res. 1998;40(2):257-64.","journal-title":"Cardiovasc Res"},{"key":"key20261013165735_B15","doi-asserted-by":"crossref","DOI":"10.1201\/9780429492563","volume-title":"Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering","author":"Strogatz","year":"2018","unstructured":"15 Strogatz SH. Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering. 2nd ed. Boca Raton: CRC Press; 2018.","edition":"2nd ed."},{"issue":"10","key":"key20261013165735_B16","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/01.RES.0000224540.97431.f0","article-title":"From pulsus to pulseless: the saga of cardiac alternans","volume":"98","author":"Weiss","year":"2006","unstructured":"16 Weiss JN, Karma A, Shiferaw Y, Chen PS, Garfinkel A, Qu Z. From pulsus to pulseless: the saga of cardiac alternans. Circ Res. 2006;98(10):1244-53.","journal-title":"Circ Res"},{"key":"key20261013165735_B17","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511817557","volume-title":"The emergence of probability: A philosophical study of early ideas about probability, induction and statistical inference","author":"Hacking","year":"2006","unstructured":"17 Hacking I. The emergence of probability: A philosophical study of early ideas about probability, induction and statistical inference. Cambridge University Press; 2006."},{"issue":"6","key":"key20261013165735_B18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/wics.1314","article-title":"Why the Monte Carlo method is so important today","volume":"6","author":"Kroese","year":"2014","unstructured":"18 Kroese DP, Brereton T, Taimre T, Botev ZI. Why the Monte Carlo method is so important today. Wiley Interdiscip Rev Comput Stat. 2014;6(6):386-92.","journal-title":"Wiley Interdiscip Rev Comput Stat"},{"issue":"11","key":"key20261013165735_B19","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1119\/10.0005620","article-title":"Kelvin's clouds","volume":"89","author":"Passon","year":"2021","unstructured":"19 Passon O. Kelvin's clouds. Am J Phys. 2021;89(11):1037-41.","journal-title":"Am J Phys"},{"key":"key20261013165735_B20","first-page":"131","article-title":"Stan Ulam, John von Neumann, and the Monte Carlo method","volume":"15","author":"Eckhardt","year":"1987","unstructured":"20 Eckhardt R. Stan Ulam, John von Neumann, and the Monte Carlo method. Los Alamos Sci. 1987;15:131-7.","journal-title":"Los Alamos Sci"},{"issue":"7","key":"key20261013165735_B21","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201800020","article-title":"Agent-Based Modeling in Molecular Systems Biology","volume":"40","author":"Soheilypour","year":"2018","unstructured":"21 Soheilypour M, Mofrad MR. Agent-Based Modeling in Molecular Systems Biology. BioEssays. 2018;40(7):e1800020.","journal-title":"BioEssays"},{"issue":"2","key":"key20261013165735_B22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.18203\/2349-3259.ijct20161408","article-title":"In silico clinical trials: how computer simulation will transform the biomedical industry","volume":"3","author":"Viceconti","year":"2016","unstructured":"22 Viceconti M, Henney A, Morley-Fletcher E. In silico clinical trials: how computer simulation will transform the biomedical industry. Int J Clin Trials. 2016;3(2):37.","journal-title":"Int J Clin Trials"},{"issue":"18","key":"key20261013165735_B23","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1001\/jama.2021.18323","article-title":"Cardiogenic Shock After Acute Myocardial Infarction: A Review","volume":"326","author":"Samsky","year":"2021","unstructured":"23 Samsky MD, Morrow DA, Proudfoot AG, Hochman JS, Thiele H, Rao SV. Cardiogenic Shock After Acute Myocardial Infarction: A Review. JAMA. 2021;326(18):1840-1850. Erratum in: JAMA. 2021;326(22):2333. Review.","journal-title":"JAMA"},{"issue":"2","key":"key20261013165735_B24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/02698590701498084","article-title":"Interpreting causality in the health sciences","volume":"21","author":"Russo","year":"2007","unstructured":"24 Russo F, Williamson J. Interpreting causality in the health sciences. Int Stud Philos Sci. 2007;21(2):157-70.","journal-title":"Int Stud Philos Sci"},{"issue":"5","key":"key20261013165735_B25","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/bib\/bby043","article-title":"In silico clinical trials: concepts and early adoptions","volume":"20","author":"Pappalardo","year":"2019","unstructured":"25 Pappalardo F, Russo G, Tshinanu FM, Viceconti M. In silico clinical trials: concepts and early adoptions. Brief Bioinform. 2019;20(5):1699-708.","journal-title":"Brief Bioinform"}],"container-title":["einstein (S\u00e3o Paulo)"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:57:44Z","timestamp":1791910664000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.einstein.br\/article\/probabilistic-clinical-studies-and-deterministic-physiology-building-a-monte-carlo-bridge-with-the-frank-project\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":25,"journal-issue":{"issue":"spe1","published-print":{"date-parts":[[2026,10,9]]}},"alternative-id":["10.31744\/einstein_journal\/2026AE2239"],"URL":"https:\/\/doi.org\/10.31744\/einstein_journal\/2026ae2239","relation":{},"ISSN":["1679-4508","2317-6385"],"issn-type":[{"value":"1679-4508","type":"print"},{"value":"2317-6385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"eAE2239"}}