{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:10:50Z","timestamp":1780063850177,"version":"3.54.0"},"reference-count":35,"publisher":"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,28]]},"DOI":"10.31744\/einstein_journal\/2026ao1837","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:41:07Z","timestamp":1780062067000},"source":"Crossref","is-referenced-by-count":0,"title":["Relationship between sugar-sweetened beverage and ultra-processed food intake: impact on leptin\/adiponectin ratio in adolescents with obesity"],"prefix":"10.31744","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-2806","authenticated-orcid":false,"given":"Ana Claudia Pelissari","family":"Kravchychyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-4349","authenticated-orcid":false,"given":"Raquel Munhoz da Silveira Campos","family":"M\u00f4nico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-7141","authenticated-orcid":false,"suffix":"Netto","given":"B\u00e1rbara","family":"Dal\u2019Molin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-6767","authenticated-orcid":false,"given":"Yasmin Alaby Martins","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5043-3671","authenticated-orcid":false,"given":"Anna Luiza Maia","family":"Balbino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-5371","authenticated-orcid":false,"given":"Helton de S\u00e1","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-6526","authenticated-orcid":false,"given":"Lila Missae","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-904X","authenticated-orcid":false,"given":"Lian","family":"Tock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-7470","authenticated-orcid":false,"given":"Ana Raimunda","family":"D\u00e2maso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16942","reference":[{"issue":"1","key":"key20260529134102_B1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1017\/S1368980017001331","article-title":"Consumption of ultra-processed foods and body fat during childhood and adolescence: a systematic review","volume":"21","author":"Costa","year":"2018","unstructured":"1 Costa CS, Del-Ponte B, Assun\u00e7\u00e3o MC, Santos IS. Consumption of ultra-processed foods and body fat during childhood and adolescence: a systematic review. Public Health Nutr. 2018;21(1):148-59.","journal-title":"Public Health Nutr"},{"issue":"1","key":"key20260529134102_B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1017\/S1368980017001379","article-title":"Household availability of ultra-processed foods and obesity in nineteen European countries","volume":"21","author":"Monteiro","year":"2018","unstructured":"2 Monteiro CA, Moubarac JC, Levy RB, Canella DS, Louzada ML, Cannon G. Household availability of ultra-processed foods and obesity in nineteen European countries. Public Health Nutr. 2018;21(1):18-26.","journal-title":"Public Health Nutr"},{"key":"key20260529134102_B3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ypmed.2015.07.018","article-title":"Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults","volume":"81","author":"Louzada","year":"2015","unstructured":"3 Louzada ML, Baraldi LG, Steele EM, Martins AP, Canella DS, Moubarac JC, et al. Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults. Prev Med. 2015;81:9-15.","journal-title":"Prev Med"},{"issue":"6","key":"key20260529134102_B4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3945\/an.114.007062","article-title":"Sugar-sweetened and artificially-sweetened beverages in relation to obesity risk","volume":"5","author":"Pereira","year":"2014","unstructured":"4 Pereira MA. Sugar-sweetened and artificially-sweetened beverages in relation to obesity risk. Adv Nutr. 2014;5(6):797-808.","journal-title":"Adv Nutr"},{"issue":"15","key":"key20260529134102_B5","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1056\/NEJMoa1203388","article-title":"A randomized trial of sugar-sweetened beverages and adolescent body weight","volume":"367","author":"Ebbeling","year":"2012","unstructured":"5 Ebbeling CB, Feldman HA, Chomitz VR, Antonelli TA, Gortmaker SL, Osganian SK, et al. A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med. 2012;367(15):1407-16.","journal-title":"N Engl J Med"},{"issue":"5","key":"key20260529134102_B6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cmet.2013.03.008","article-title":"Mechanisms and metabolic implications of regional differences among fat depots","volume":"17","author":"Tchkonia","year":"2013","unstructured":"6 Tchkonia T, Thomou T, Zhu Y, Karagiannides I, Pothoulakis C, Jensen MD, et al. Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab. 2013;17(5):644-56.","journal-title":"Cell Metab"},{"key":"key20260529134102_B7","doi-asserted-by":"crossref","first-page":"108561","DOI":"10.1016\/j.jnutbio.2020.108561","article-title":"Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications","volume":"89","author":"Montserrat-de la Paz","year":"2021","unstructured":"7 Montserrat-de la Paz S, P\u00e9rez-P\u00e9rez A, Vilari\u00f1o-Garc\u00eda T, Jim\u00e9nez-Cortegana C, Muriana FJ, Mill\u00e1n-Linares MC, et al. Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications. J Nutr Biochem. 2021;89:108561.","journal-title":"J Nutr Biochem"},{"issue":"7","key":"key20260529134102_B8","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.peptides.2011.04.025","article-title":"Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss","volume":"32","author":"D\u00e2maso","year":"2011","unstructured":"8 D\u00e2maso AR, de Piano A, Sanches PL, Corgosinho F, Tock L, Oyama LM, et al. Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss. Peptides. 2011;32(7):1384-91.","journal-title":"Peptides"},{"issue":"2","key":"key20260529134102_B9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11684-013-0263-5","article-title":"Leptin signaling and leptin resistance","volume":"7","author":"Zhou","year":"2013","unstructured":"9 Zhou Y, Rui L. Leptin signaling and leptin resistance. Front Med. 2013;7(2):207-22.","journal-title":"Front Med"},{"issue":"1","key":"key20260529134102_B10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/1806-9282.61.01.072","article-title":"Relationship between adiponectin, obesity and insulin resistance","volume":"61","author":"Balsan","year":"2015","unstructured":"10 Balsan GA, Vieira JL, Oliveira AM, Portal VL. Relationship between adiponectin, obesity and insulin resistance. Rev Assoc Med Bras. 2015;61(1):72-80.","journal-title":"Rev Assoc Med Bras"},{"issue":"2","key":"key20260529134102_B11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/pedi.12964","article-title":"Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity","volume":"21","author":"Frithioff-B\u00f8js\u00f8e","year":"2020","unstructured":"11 Frithioff-B\u00f8js\u00f8e C, Lund MA, Lausten-Thomsen U, Hedley PL, Pedersen O, Christiansen M, et al. Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. Pediatr Diabetes. 2020;21(2):194-202.","journal-title":"Pediatr Diabetes"},{"key":"key20260529134102_B12","doi-asserted-by":"crossref","first-page":"155111","DOI":"10.1016\/j.cyto.2020.155111","article-title":"Influence of magnitude of weight loss on Adipo\/lep ratio in adolescents with obesity undergoing multicomponent therapy","volume":"131","author":"Alaby Martins Ferreira","year":"2020","unstructured":"12 Alaby Martins Ferreira Y, Claudia Pelissari Kravchychyn A, de Castro Ferreira Vicente S, Munhoz da Silveira Campos R, Tock L, Missae Oyama L, et al. Influence of magnitude of weight loss on Adipo\/lep ratio in adolescents with obesity undergoing multicomponent therapy. Cytokine. 2020;131:155111.","journal-title":"Cytokine"},{"issue":"3","key":"key20260529134102_B13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/adc.51.3.170","article-title":"Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty","volume":"51","author":"Tanner","year":"1976","unstructured":"13 Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976;51(3):170-9.","journal-title":"Arch Dis Child"},{"key":"key20260529134102_B14","first-page":"164","volume-title":"Tabela Brasileira de Composi\u00e7\u00e3o de Alimentos (TACO)","author":"N\u00facleo de Estudos e Pesquisas em Alimenta\u00e7\u00e3o (NEPA). Universidade Estadual de Campinas (UNICAMP)","unstructured":"14 N\u00facleo de Estudos e Pesquisas em Alimenta\u00e7\u00e3o (NEPA). Universidade Estadual de Campinas (UNICAMP). Tabela Brasileira de Composi\u00e7\u00e3o de Alimentos (TACO). Campinas: NEPA-UNICAMP; 164."},{"key":"key20260529134102_B15","volume-title":"Tabela de composi\u00e7\u00e3o de alimentos: suporte para decis\u00e3o nutricional","author":"Philippi","year":"2020","unstructured":"15 Philippi ST. Tabela de composi\u00e7\u00e3o de alimentos: suporte para decis\u00e3o nutricional. 7th ed. Barueri: Manole; 2020.","edition":"7th ed"},{"key":"key20260529134102_B16","volume-title":"Tabela de composi\u00e7\u00e3o qu\u00edmica dos alimentos","author":"Franco","year":"2008","unstructured":"16 Franco G. Tabela de composi\u00e7\u00e3o qu\u00edmica dos alimentos. 9th ed. Sao Paulo, Sao Paulo: Editora Atheneu; 2008.","edition":"9th ed"},{"issue":"1-3","key":"key20260529134102_B17","first-page":"28","article-title":"The star shines bright","volume":"7","author":"Monteiro","year":"2016","unstructured":"17 Monteiro CA, Ricardo CZ, Calixto G, Machado P, Martins C, Steele EM, Baraldi LG, et al. NOVA. The star shines bright. World Nutrition. 2016;7(1-3):28-38.","journal-title":"World Nutrition"},{"issue":"1","key":"key20260529134102_B18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1515\/hmbci-2013-0053","article-title":"The role of leptin\/adiponectin ratio in metabolic syndrome and diabetes","volume":"18","author":"L\u00f3pez-Jaramillo","year":"2014","unstructured":"18 L\u00f3pez-Jaramillo P, G\u00f3mez-Arbel\u00e1ez D, L\u00f3pez-L\u00f3pez J, L\u00f3pez-L\u00f3pez C, Mart\u00ednez-Ortega J, G\u00f3mez-Rodr\u00edguez A, et al. The role of leptin\/adiponectin ratio in metabolic syndrome and diabetes. Horm Mol Biol Clin Investig. 2014;18(1):37-45.","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"8","key":"key20260529134102_B19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1515\/JPEM.2004.17.8.1069","article-title":"Correlates of adiponectin and the leptin\/adiponectin ratio in obese and non-obese children","volume":"17","author":"Diamond","year":"2004","unstructured":"19 Diamond FB Jr, Cuthbertson D, Hanna S, Eichler D. Correlates of adiponectin and the leptin\/adiponectin ratio in obese and non-obese children. J Pediatr Endocrinol Metab. 2004;17(8):1069-75.","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"1","key":"key20260529134102_B20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s44324-025-00056-3","article-title":"Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity","volume":"3","author":"Morys","year":"2025","unstructured":"20 Morys F, Kanyamibwa A, F\u00e4ngstr\u00f6m D, Tweedale M, Pastor-Bernier A, Azizi H, et al. Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity. NPJ Metab Health Dis. 2025;3(1):13.","journal-title":"NPJ Metab Health Dis"},{"issue":"2","key":"key20260529134102_B21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","unstructured":"21 Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci. 2009;29(2):359-70.","journal-title":"J Neurosci"},{"key":"key20260529134102_B22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000452908","article-title":"Leptin, Neuroinflammation and Obesity","volume":"48","author":"Dragano","year":"2017","unstructured":"22 Dragano NR, Haddad-Tovolli R, Velloso LA. Leptin, Neuroinflammation and Obesity. Front Horm Res. 2017;48:84-96.","journal-title":"Front Horm Res"},{"issue":"6","key":"key20260529134102_B23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","unstructured":"23 Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010;140(6):900-17.","journal-title":"Cell"},{"issue":"12","key":"key20260529134102_B24","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1161\/01.ATV.0000186208.06964.91","article-title":"Fast food, central nervous system insulin resistance, and obesity","volume":"25","author":"Isganaitis","year":"2005","unstructured":"24 Isganaitis E, Lustig RH. Fast food, central nervous system insulin resistance, and obesity. Arterioscler Thromb Vasc Biol. 2005;25(12):2451-62.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"key20260529134102_B25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/nure.12048","article-title":"Factors that determine energy compensation: a systematic review of preload studies","volume":"71","author":"Almiron-Roig","year":"2013","unstructured":"25 Almiron-Roig E, Palla L, Guest K, Ricchiuti C, Vint N, Jebb SA, et al. Factors that determine energy compensation: a systematic review of preload studies. Nutr Rev. 2013;71(7):458-73.","journal-title":"Nutr Rev"},{"issue":"2","key":"key20260529134102_B26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.21149\/9038","article-title":"Association between ultra-processed food consumption and the nutrient profile of the Colombian diet in 2005","volume":"61","author":"Parra","year":"2019","unstructured":"26 Parra DC, da Costa-Louzada ML, Moubarac JC, Bertazzi-Levy R, Khandpur N, Cediel G, et al. Association between ultra-processed food consumption and the nutrient profile of the Colombian diet in 2005. Salud Publica Mex. 2019;61(2):147-54.","journal-title":"Salud Publica Mex"},{"issue":"5","key":"key20260529134102_B27","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1039\/C6FO00107F","article-title":"Minimally processed foods are more satiating and less hyperglycemic than ultra-processed foods: a preliminary study with 98 ready-to-eat foods","volume":"7","author":"Fardet","year":"2016","unstructured":"27 Fardet A. Minimally processed foods are more satiating and less hyperglycemic than ultra-processed foods: a preliminary study with 98 ready-to-eat foods. Food Funct. 2016;7(5):2338-46.","journal-title":"Food Funct"},{"key":"key20260529134102_B28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnut.2019.00077","article-title":"An interdisciplinary weight loss program improves body composition and metabolic profile in adolescents with obesity: associations with the dietary inflammatory index","volume":"6","author":"Ferreira","year":"2019","unstructured":"28 Ferreira YA, Kravchychyn AC, Vicente SC, Campos RM, Tock L, Oyama LM, et al. An interdisciplinary weight loss program improves body composition and metabolic profile in adolescents with obesity: associations with the dietary inflammatory index. Front Nutr. 2019;6:77.","journal-title":"Front Nutr"},{"issue":"3","key":"key20260529134102_B29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/JLB.MR1218-478R","article-title":"Leptin in the regulation of the immunometabolism of adipose tissue-macrophages","volume":"106","author":"Monteiro","year":"2019","unstructured":"29 Monteiro L, Pereira JA, Palhinha L, Moraes-Vieira PM. Leptin in the regulation of the immunometabolism of adipose tissue-macrophages. J Leukoc Biol. 2019;106(3):703-16.","journal-title":"J Leukoc Biol"},{"issue":"7","key":"key20260529134102_B30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/00365513.2016.1210226","article-title":"Reference values for serum leptin in healthy non-obese children and adolescents","volume":"76","author":"Lausten-Thomsen","year":"2016","unstructured":"30 Lausten-Thomsen U, Christiansen M, Louise Hedley P, Esmann Fonvig C, Stjernholm T, Pedersen O, et al. Reference values for serum leptin in healthy non-obese children and adolescents. Scand J Clin Lab Invest. 2016;76(7):561-7.","journal-title":"Scand J Clin Lab Invest"},{"key":"key20260529134102_B31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cca.2015.07.012","article-title":"Reference values for serum total adiponectin in healthy non-obese children and adolescents","volume":"450","author":"Lausten-Thomsen","year":"2015","unstructured":"31 Lausten-Thomsen U, Christiansen M, Fonvig CE, Trier C, Pedersen O, Hansen T, et al. Reference values for serum total adiponectin in healthy non-obese children and adolescents. Clin Chim Acta. 2015;450:11-4.","journal-title":"Clin Chim Acta"},{"key":"key20260529134102_B32","doi-asserted-by":"crossref","first-page":"111188","DOI":"10.1016\/j.nut.2021.111188","article-title":"Adipocytokine and appetite-regulating hormone response to weight loss in adolescents with obesity: impact of weight loss magnitude","volume":"87-88","author":"Kravchychyn","year":"2021","unstructured":"32 Kravchychyn AC, Campos RM, Oliveira E Silva L, Ferreira YA, Corgosinho FC, Masquio DC, et al. Adipocytokine and appetite-regulating hormone response to weight loss in adolescents with obesity: impact of weight loss magnitude. Nutrition. 2021;87-88:111188.","journal-title":"Nutrition"},{"key":"key20260529134102_B33","doi-asserted-by":"crossref","DOI":"10.31744\/einstein_journal\/2022AO6619","article-title":"Degree of food processing and association with overweight and abdominal obesity in adolescents","volume":"20","author":"Souza","year":"2022","unstructured":"33 Souza SF, Concei\u00e7\u00e3o-Machado ME, Costa PR, Cunha CM, Queiroz VA, Santana ML, et al. Degree of food processing and association with overweight and abdominal obesity in adolescents. einstein (S\u00e3o Paulo). 2022;20:eAO6619.","journal-title":"einstein (S\u00e3o Paulo)"},{"issue":"4","key":"key20260529134102_B34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1089\/chi.2014.0117","article-title":"Sugar-Sweetened Beverages and Obesity among Children and Adolescents: A Review of Systematic Literature Reviews","volume":"11","author":"Keller","year":"2015","unstructured":"34 Keller A, Bucher Della Torre S. Sugar-Sweetened Beverages and Obesity among Children and Adolescents: A Review of Systematic Literature Reviews. Child Obes. 2015;11(4):338-46. Review.","journal-title":"Child Obes"},{"issue":"3","key":"key20260529134102_B35","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/nu15030764","article-title":"Association between food, beverages and overweight\/obesity in children and adolescents: a systematic review and meta-analysis of observational studies","volume":"15","author":"Jakobsen","year":"2023","unstructured":"35 Jakobsen DD, Brader L, Bruun JM. Association between food, beverages and overweight\/obesity in children and adolescents: a systematic review and meta-analysis of observational studies. Nutrients. 2023;15(3):456.","journal-title":"Nutrients"}],"container-title":["einstein (S\u00e3o Paulo)"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:41:12Z","timestamp":1780062072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.einstein.br\/article\/relationship-between-sugar-sweetened-beverage-and-ultra-processed-food-intake-impact-on-leptin-adiponectin-ratio-in-adolescents-with-obesity\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"alternative-id":["10.31744\/einstein_journal\/2026AO1837"],"URL":"https:\/\/doi.org\/10.31744\/einstein_journal\/2026ao1837","relation":{},"ISSN":["1679-4508","2317-6385"],"issn-type":[{"value":"1679-4508","type":"print"},{"value":"2317-6385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"eAO1837"}}