{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:55:20Z","timestamp":1790618120545,"version":"4.1.0"},"reference-count":30,"publisher":"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"DOI":"10.31744\/einstein_journal\/2026ao2319","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:56:02Z","timestamp":1790614562000},"source":"Crossref","is-referenced-by-count":0,"title":["Quantification of Y RNAs in peripheral blood mononuclear cells from patients with ankylosing spondylitis and healthy controls"],"prefix":"10.31744","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-254X","authenticated-orcid":false,"given":"Guilherme","family":"Castellani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-4200","authenticated-orcid":false,"given":"Matheus","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-4917","authenticated-orcid":false,"given":"Al\u00e9ia Harumi Uchibaba","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-1536","authenticated-orcid":false,"given":"Giovana Paola Zaccarias","family":"Bemvides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3313-5458","authenticated-orcid":false,"given":"Julyane","family":"Schavaren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-3123","authenticated-orcid":false,"given":"Larissa Danielle Bahls","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-7567","authenticated-orcid":false,"suffix":"Neto","given":"Quirino Alves de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16942","reference":[{"issue":"4","key":"key20260928165555_B1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/BOR.0b013e32833ac5cc","article-title":"New approaches to diagnosis and classification of axial and peripheral spondyloarthritis","volume":"22","author":"Rudwaleit","year":"2010","unstructured":"1. Rudwaleit M. New approaches to diagnosis and classification of axial and peripheral spondyloarthritis. Curr Opin Rheumatol. 2010;22(4):375-80.","journal-title":"Curr Opin Rheumatol"},{"key":"key20260928165555_B2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.624632","article-title":"From the genetics of ankylosing spondylitis to new biology and drug target discovery","volume":"12","author":"Nancy","year":"2021","unstructured":"2. Nancy Z, Yan L, Hui S, Paul B, Liye C. From the genetics of ankylosing spondylitis to new biology and drug target discovery. Front Immunol. 2021;12:624632.","journal-title":"Front Immunol"},{"issue":"2","key":"key20260928165555_B3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00296-002-0237-4","article-title":"Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis","volume":"23","author":"Feldtkeller","year":"2003","unstructured":"3. Feldtkeller E, Khan MA, van der Heijde D, van der Linden S, Braun J. Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int. 2003;23(2):61-6.","journal-title":"Rheumatol Int"},{"issue":"2","key":"key20260928165555_B4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/rheumatology\/kem269","article-title":"Breakthroughs in genetic studies of ankylosing spondylitis","volume":"47","author":"Brown","year":"2008","unstructured":"4. Brown MA. Breakthroughs in genetic studies of ankylosing spondylitis. Rheumatology (Oxford). 2008;47(2):132-7.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"key20260928165555_B5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/MAJ.0b013e31820f8caf","article-title":"Epidemiology of spondyloarthritis in Brazil","volume":"341","author":"Sampaio-Barros","year":"2011","unstructured":"5. Sampaio-Barros PD. Epidemiology of spondyloarthritis in Brazil. Am J Med Sci. 2011;341(4):287-8.","journal-title":"Am J Med Sci"},{"issue":"4","key":"key20260928165555_B6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/berh.2002.0243","article-title":"Genetic aspects of ankylosing spondylitis","volume":"16","author":"Khan","year":"2002","unstructured":"6. Khan MA, Ball EJ. Genetic aspects of ankylosing spondylitis. Best Pract Res Clin Rheumatol. 2002;16(4):675-90.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"key20260928165555_B7","article-title":"Emerging roles of long non-coding RNAs in ankylosing spondylitis","volume":"13","author":"Sun","year":"2022","unstructured":"7. Sun R, Wang X, Sun X, Zhao B, Zhang X, Gong X, et al. Emerging roles of long non-coding RNAs in ankylosing spondylitis. Front Immunol. 2022;13:790924.","journal-title":"Front Immunol"},{"key":"key20260928165555_B8","article-title":"Noncoding RNAs involved in the pathogenesis of ankylosing spondylitis","volume":"2019","author":"Chen","year":"2019","unstructured":"8. Chen C, Rong T, Li Z, Shen J. Noncoding RNAs involved in the pathogenesis of ankylosing spondylitis. BioMed Res Int. 2019;2019:6920281.","journal-title":"BioMed Res Int"},{"issue":"5","key":"key20260928165555_B9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.2174\/0115733971283982240118045203","article-title":"Study on the expression and potential function of lncRNA in peripheral blood of patients with ankylosing spondylitis","volume":"20","author":"Hong-Yuan","year":"2024","unstructured":"9. Hong-Yuan X, Yi-Ping T, Ting Y, Xia L, Quan-Bo Z, Yu-Feng Q, et al. Study on the expression and potential function of lncRNA in peripheral blood of patients with ankylosing spondylitis. Curr Rheumatol Rev. 2024;20(5):544-54.","journal-title":"Curr Rheumatol Rev"},{"issue":"35","key":"key20260928165555_B10","doi-asserted-by":"crossref","first-page":"24799","DOI":"10.1074\/jbc.274.35.24799","article-title":"Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis","volume":"274","author":"Rutjes","year":"1999","unstructured":"10. Rutjes SA, van der Heijden A, Utz PJ, van Venrooij WJ, Pruijn GJ. Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. J Biol Chem. 1999;274(35):24799-807.","journal-title":"J Biol Chem"},{"key":"key20260928165555_B11","first-page":"327","volume-title":"Adv Exp Med Biol","author":"Valkov","year":"2020","unstructured":"11. Valkov N, Das S. RNAs: biogenesis, function and implications for the cardiovascular system. Adv Exp Med Biol. 2020;1229:327-42."},{"issue":"9","key":"key20260928165555_B12","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/bies.201100048","article-title":"Are the Ro RNP-associated Y RNAs concealing microRNAs? Y RNA-derived miRNAs may be involved in autoimmunity","volume":"33","author":"Verhagen","year":"2011","unstructured":"12. Verhagen AP, Pruijn GJ. Are the Ro RNP-associated Y RNAs concealing microRNAs? Y RNA-derived miRNAs may be involved in autoimmunity. BioEssays. 2011;33(9):674-82.","journal-title":"BioEssays"},{"issue":"5","key":"key20260928165555_B13","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/sj.bjc.6604254","article-title":"Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation","volume":"98","author":"Christov","year":"2008","unstructured":"13. Christov CP, Trivier E, Krude T. Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation. Br J Cancer. 2008;98(5):981-8.","journal-title":"Br J Cancer"},{"key":"key20260928165555_B14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.03164","article-title":"Circulating Y-RNAs in extracellular vesicles and ribonucleoprotein complexes: implications for the immune system","volume":"9","author":"Driedonks","year":"2019","unstructured":"14. Driedonks TA, Nolte-'t Hoen EN. Circulating Y-RNAs in extracellular vesicles and ribonucleoprotein complexes: implications for the immune system. Front Immunol. 2019;9:3164.","journal-title":"Front Immunol"},{"issue":"10","key":"key20260928165555_B15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013673","article-title":"Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication","volume":"5","author":"Langley","year":"2010","unstructured":"15. Langley AR, Chambers H, Christov CP, Krude T. Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication. PLoS One. 2010;5(10):e13673.","journal-title":"PLoS One"},{"issue":"Pt 16","key":"key20260928165555_B16","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1242\/jcs.047563","article-title":"Y RNA functions at the initiation step of mammalian chromosomal DNA replication","volume":"122","author":"Krude","year":"2009","unstructured":"16. Krude T, Christov CP, Hyrien O, Marheineke K. Y RNA functions at the initiation step of mammalian chromosomal DNA replication. J Cell Sci. 2009; 122(Pt 16):2836-45.","journal-title":"J Cell Sci"},{"issue":"6","key":"key20260928165555_B17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection","volume":"68","author":"Rudwaleit","year":"2009","unstructured":"17. Rudwaleit M, van der Heijde D, Landew\u00e9 R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68(6):777-83.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"key20260928165555_B18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/ard.2010.133645","article-title":"The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general","volume":"70","author":"Rudwaleit","year":"2011","unstructured":"18. Rudwaleit M, van der Heijde D, Landew\u00e9 R, Akkoc N, Brandt J, Chou CT, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis. 2011;70(1):25-31.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"key20260928165555_B19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-? ? C(T)) Method","volume":"25","author":"Livak","year":"2001","unstructured":"19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-? ? C(T)) Method. Methods. 2001;25(4):402-8.","journal-title":"Methods"},{"key":"key20260928165555_B20","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4955761","article-title":"IL-33\/ST2 activation is involved in Ro60-regulated photosensitivity in cutaneous lupus erythematosus","volume":"2022","author":"Song","year":"2022","unstructured":"20. Song Y, Wei F, Liu Y, Han F, Ma L, Zhuang Y, et al. IL-33\/ST2 activation is involved in Ro60-regulated photosensitivity in cutaneous lupus erythematosus. Mediators Inflamm. 2022;2022:4955761.","journal-title":"Mediators Inflamm"},{"issue":"1","key":"key20260928165555_B21","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.429","article-title":"RNY (YRNA)-derived small RNAs regulate cell death and inflammation in monocytes\/macrophages","volume":"8","author":"Hizir","year":"2017","unstructured":"21. Hizir Z, Bottini S, Grandjean V, Trabucchi M, Repetto E. RNY (YRNA)-derived small RNAs regulate cell death and inflammation in monocytes\/macrophages. Cell Death Dis. 2017;8(1):e2530.","journal-title":"Cell Death Dis"},{"key":"key20260928165555_B22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biocel.2015.07.003","article-title":"Functional roles of non-coding Y RNAs","volume":"66","author":"Kowalski","year":"2015","unstructured":"22. Kowalski MP, Krude T. Functional roles of non-coding Y RNAs. Int J Biochem Cell Biol. 2015;66:20-9.","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"key20260928165555_B23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10409238.2019.1608902","article-title":"Ro60 and Y RNAs: structure, functions, and roles in autoimmunity","volume":"54","author":"Boccitto","year":"2019","unstructured":"23. Boccitto M, Wolin SL. Ro60 and Y RNAs: structure, functions, and roles in autoimmunity. Crit Rev Biochem Mol Biol. 2019;54(2):133-52.","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"12","key":"key20260928165555_B24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg3813","article-title":"A census of human RNA-binding proteins","volume":"15","author":"Gerstberger","year":"2014","unstructured":"24. Gerstberger S, Hafner M, Tuschl T. A census of human RNA-binding proteins. Nat Rev Genet. 2014;15(12):829-45.","journal-title":"Nat Rev Genet"},{"issue":"4","key":"key20260928165555_B25","first-page":"247","article-title":"Linking RNA processing to immune regulation","volume":"23","author":"Chen","year":"2023","unstructured":"25. Chen LL. Linking RNA processing to immune regulation. Nat Rev Immunol. 2023;23(4):247-60.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"key20260928165555_B26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-020711-075013","article-title":"microRNA regulation of inflammatory responses","volume":"30","author":"O'Connell","year":"2012","unstructured":"26. O'Connell RM, Rao DS, Baltimore D. microRNA regulation of inflammatory responses. Annu Rev Immunol. 2012;30(1):295-312.","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"key20260928165555_B27","first-page":"115","article-title":"Extracellular vesicles and non-coding RNAs in inflammatory diseases","volume":"20","author":"Shurtleff","year":"2024","unstructured":"27. Shurtleff MJ, Temoche-Diaz MM, Karfilis KV, Ri S, Schekman R. Extracellular vesicles and non-coding RNAs in inflammatory diseases. Nat Rev Rheumatol. 2024;20(2):115-30.","journal-title":"Nat Rev Rheumatol"},{"key":"key20260928165555_B28","article-title":"Emerging roles of non-coding RNAs as biomarkers in autoimmune diseases","volume":"15","author":"Li","year":"2024","unstructured":"28. Li X, Wu Z, Fu X, Han W. Emerging roles of non-coding RNAs as biomarkers in autoimmune diseases. Front Immunol. 2024;15:1324501.","journal-title":"Front Immunol"},{"key":"key20260928165555_B29","article-title":"Circulating small non-coding RNAs as biomarkers of disease","volume":"67","author":"Dhahbi","year":"2021","unstructured":"29. Dhahbi JM. Circulating small non-coding RNAs as biomarkers of disease. Ageing Res Rev. 2021;67:101300.","journal-title":"Ageing Res Rev"},{"issue":"12","key":"key20260928165555_B30","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","unstructured":"30. Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011; 12(12):861-74.","journal-title":"Nat Rev Genet"}],"container-title":["einstein (S\u00e3o Paulo)"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:56:07Z","timestamp":1790614567000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.einstein.br\/article\/quantification-of-y-rnas-in-peripheral-blood-mononuclear-cells-from-patients-with-ankylosing-spondylitis-and-healthy-controls\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":30,"alternative-id":["10.31744\/einstein_journal\/2026AO2319"],"URL":"https:\/\/doi.org\/10.31744\/einstein_journal\/2026ao2319","relation":{},"ISSN":["1679-4508","2317-6385"],"issn-type":[{"value":"1679-4508","type":"print"},{"value":"2317-6385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"eAO2319"}}