{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:28:09Z","timestamp":1766068089772,"version":"3.48.0"},"reference-count":58,"publisher":"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,17]]},"DOI":"10.31744\/einstein_journal\/2026rw0695","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:21:33Z","timestamp":1766067693000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of non-invasive ventilation and high-flow nasal cannula on hospital mortality in COVID-19-induced acute respiratory failure: a meta-analysis"],"prefix":"10.31744","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5697-0140","authenticated-orcid":false,"given":"Jakson Henrique","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0804-8967","authenticated-orcid":false,"given":"Anna Lu\u00edsa Ara\u00fajo","family":"Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0227-3884","authenticated-orcid":false,"given":"Redha","family":"Taiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-2042","authenticated-orcid":false,"given":"Bruno Amorim","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-0932","authenticated-orcid":false,"given":"Anderson Brasil","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-125X","authenticated-orcid":false,"given":"Wagner Souza","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-6172","authenticated-orcid":false,"given":"Maria das Gra\u00e7as Rodrigues de","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-6815","authenticated-orcid":false,"given":"Daniella Cunha","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-4395","authenticated-orcid":false,"given":"Armele de F\u00e1tima Dornelas","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-8300","authenticated-orcid":false,"given":"Shirley Lima","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16942","reference":[{"key":"key20251218142127_B1","article-title":"Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection","volume":"18","author":"Corr\u00eaa","year":"2020","unstructured":". Corr\u00eaa TD, Matos GF, Bravim BA, Cordioli RL, Garrido AD, Assun\u00e7\u00e3o MS, et al. Intensive support recommendations for critically-ill patients with suspected or confirmed COVID-19 infection. einstein (Sao Paulo). 2020;18:eAE5793.","journal-title":"einstein (Sao Paulo)"},{"issue":"10223","key":"key20251218142127_B2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","unstructured":". Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.","journal-title":"Lancet"},{"issue":"9","key":"key20251218142127_B3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s12630-020-01740-2","article-title":"High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission","volume":"67","author":"Agarwal","year":"2020","unstructured":". Agarwal A, Basmaji J, Muttalib F, Granton D, Chaudhuri D, Chetan D, et al. High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission. Can J Anaesth. 2020;67(9):1217-48.","journal-title":"Can J Anaesth"},{"issue":"3","key":"key20251218142127_B4","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/S2589-7500(20)30316-2","article-title":"A simple nomogram for predicting failure of non-invasive respiratory strategies in adults with COVID-19: a retrospective multicentre study","volume":"3","author":"Liu","year":"2021","unstructured":". Liu L, Xie J, Wu W, Chen H, Li S, He H, et al. A simple nomogram for predicting failure of non-invasive respiratory strategies in adults with COVID-19: a retrospective multicentre study. Lancet Digit Health. 2021;3(3):e166-74.","journal-title":"Lancet Digit Health"},{"issue":"1","key":"key20251218142127_B5","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01198-2020","article-title":"Awake prone positioning for non-intubated oxygen dependent COVID-19 pneumonia patients","volume":"56","author":"Ng","year":"2020","unstructured":". Ng Z, Tay WC, Ho CH. Awake prone positioning for non-intubated oxygen dependent COVID-19 pneumonia patients. Eur Respir J. 2020;56(1):2001198.","journal-title":"Eur Respir J"},{"key":"key20251218142127_B6","doi-asserted-by":"crossref","DOI":"10.1177\/17534666221087847","article-title":"High-flow nasal cannula versus noninvasive ventilation in patients with COVID-19: a systematic review and meta-analysis","volume":"16","author":"He","year":"2022","unstructured":". He Y, Liu N, Zhuang X, Wang X, Ma W. High-flow nasal cannula versus noninvasive ventilation in patients with COVID-19: a systematic review and meta-analysis. Ther Adv Respir Dis. 2022;16:17534666221087847.","journal-title":"Ther Adv Respir Dis"},{"key":"key20251218142127_B7","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","unstructured":". Higgins JP, Altman DG, G\u00f8tzsche PC, J\u00fcni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA; Cochrane Bias Methods Group; Cochrane Statistical Methods Group. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.","journal-title":"BMJ"},{"issue":"71","key":"key20251218142127_B8","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","unstructured":". Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372(71):n71.","journal-title":"BMJ"},{"issue":"1","key":"key20251218142127_B9","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","unstructured":". Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210.","journal-title":"Syst Rev"},{"issue":"23","key":"key20251218142127_B10","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin Definition","volume":"307","author":"ARDS Definition Task Force","year":"2012","unstructured":". ARDS Definition Task Force; Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23):2526-33.","journal-title":"JAMA"},{"issue":"17","key":"key20251218142127_B11","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1001\/jama.2021.4682","article-title":"COVID-ICU Gemelli Study Group. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial","volume":"325","author":"Grieco","year":"2021","unstructured":". Grieco DL, Menga LS, Cesarano M, Ros\u00e0 T, Spadaro S, Bitondo MM, Montomoli J, Fal\u00f2 G, Tonetti T, Cutuli SL, Pintaudi G, Tanzarella ES, Piervincenzi E, Bongiovanni F, Dell'Anna AM, Delle Cese L, Berardi C, Carelli S, Bocci MG, Montini L, Bello G, Natalini D, De Pascale G, Velardo M, Volta CA, Ranieri VM, Conti G, Maggiore SM, Antonelli M; COVID-ICU Gemelli Study Group. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial. JAMA. 2021;325(17):1731-43.","journal-title":"JAMA"},{"issue":"3","key":"key20251218142127_B12","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13435","article-title":"The value of high-flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia","volume":"51","author":"Teng","year":"2021","unstructured":". Teng XB, Shen Y, Han MF, Yang G, Zha L, Shi JF. The value of high-flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia. Eur J Clin Invest. 2021;51(3):e13435.","journal-title":"Eur J Clin Invest"},{"issue":"12","key":"key20251218142127_B13","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.4187\/respcare.09130","article-title":"Comparison of High-Flow Nasal Cannula and Noninvasive Ventilation in Acute Hypoxemic Respiratory Failure Due to Severe COVID-19 Pneumonia","volume":"66","author":"Nair","year":"2021","unstructured":". Nair PR, Haritha D, Behera S, Kayina CA, Maitra S, Anand RK, et al. Comparison of High-Flow Nasal Cannula and Noninvasive Ventilation in Acute Hypoxemic Respiratory Failure Due to Severe COVID-19 Pneumonia. Respir Care. 2021;66(12):1824-30.","journal-title":"Respir Care"},{"issue":"21","key":"key20251218142127_B14","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2021.20714","article-title":"Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: a Randomized Clinical Trial","volume":"326","author":"Ospina-Tasc\u00f3n","year":"2021","unstructured":". Ospina-Tasc\u00f3n GA, Calder\u00f3n-Tapia LE, Garc\u00eda AF, Zarama V, G\u00f3mez-\u00c1lvarez F, \u00c1lvarez-Saa T, Pardo-Ot\u00e1lvaro S, Bautista-Rinc\u00f3n DF, Vargas MP, Aldana-D\u00edaz JL, Marulanda \u00c1, Guti\u00e9rrez A, Var\u00f3n J, G\u00f3mez M, Ochoa ME, Escobar E, Uma\u00f1a M, D\u00edez J, Tob\u00f3n GJ, Albornoz LL, Celem\u00edn Fl\u00f3rez CA, Ruiz GO, C\u00e1ceres EL, Reyes LF, Damiani LP, Cavalcanti AB; HiFLo-Covid Investigators. Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: a Randomized Clinical Trial. JAMA. 2021;326(21):2161-71. Erratum in: JAMA. 2022;327(11):1093.","journal-title":"JAMA"},{"issue":"6","key":"key20251218142127_B15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1001\/jama.2022.0028","article-title":"Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial","volume":"327","author":"Perkins","year":"2022","unstructured":". Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, Bradley JM, Dark P, Dave C, De Soyza A, Dennis AV, Devrell A, Fairbairn S, Ghani H, Gorman EA, Green CA, Hart N, Hee SW, Kimbley Z, Madathil S, McGowan N, Messer B, Naisbitt J, Norman C, Parekh D, Parkin EM, Patel J, Regan SE, Ross C, Rostron AJ, Saim M, Simonds AK, Skilton E, Stallard N, Steiner M, Vancheeswaran R, Yeung J, McAuley DF; RECOVERY-RS Collaborators. Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial. JAMA. 2022;327(6):546-58.","journal-title":"JAMA"},{"issue":"5","key":"key20251218142127_B16","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02130-2020","article-title":"Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia","volume":"56","author":"Franco","year":"2020","unstructured":". Franco C, Facciolongo N, Tonelli R, Dongilli R, Vianello A, Pisani L, et al. Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia. Eur Respir J. 2020; 56(5):2002130.","journal-title":"Eur Respir J"},{"issue":"2","key":"key20251218142127_B17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/IJCIIS.IJCIIS_181_20","article-title":"Characteristics and outcomes of patients receiving high flow nasal cannula therapy prior to mechanical ventilation in COVID-19 respiratory failure: a prospective observational study","volume":"11","author":"Hansen","year":"2021","unstructured":". Hansen CK, Stempek S, Liesching T, Lei Y, Dargin J. Characteristics and outcomes of patients receiving high flow nasal cannula therapy prior to mechanical ventilation in COVID-19 respiratory failure: a prospective observational study. Int J Crit Illn Inj Sci. 2021;11(2):56-60.","journal-title":"Int J Crit Illn Inj Sci"},{"issue":"1","key":"key20251218142127_B18","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-021-03580-y","article-title":"Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort","volume":"25","author":"Wendel Garcia","year":"2021","unstructured":". Wendel Garcia PD, Aguirre-Bermeo H, Buehler PK, Alfaro-Farias M, Yuen B, David S, Tschoellitsch T, Wengenmayer T, Korsos A, Fogagnolo A, Kleger GR, Wu MA, Colombo R, Turrini F, Potalivo A, Rezoagli E, Rodr\u00edguez-Garc\u00eda R, Castro P, Lander-Azcona A, Mart\u00edn-Delgado MC, Lozano-G\u00f3mez H, Ensner R, Michot MP, Gehring N, Schott P, Siegemund M, Merki L, Wiegand J, Jeitziner MM, Laube M, Salomon P, Hillgaertner F, Dullenkopf A, Ksouri H, Cereghetti S, Grazioli S, B\u00fcrkle C, Marrel J, Fleisch I, Perez MH, Baltussen Weber A, Ceruti S, Marquardt K, H\u00fcbner T, Redecker H, Studhalter M, Stephan M, Selz D, Pietsch U, Ristic A, Heise A, Meyer Zu Bentrup F, Franchitti Laurent M, Fodor P, Gaspert T, Haberthuer C, Colak E, Heuberger DM, Fumeaux T, Montomoli J, Guerci P, Schuepbach RA, Hilty MP, Roche-Campo F; RISC-19-ICU Investigators. Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort. Crit Care. 2021;25(1):175.","journal-title":"Crit Care"},{"key":"key20251218142127_B19","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106481","article-title":"Effects of non-invasive respiratory support on gas exchange and outcomes in COVID-19 outside the ICU","volume":"185","author":"Gough","year":"2021","unstructured":". Gough C, Casey M, McCartan TA, Franciosi AN, Nash D, Doyle D, et al. Effects of non-invasive respiratory support on gas exchange and outcomes in COVID-19 outside the ICU. Respir Med. 2021;185:106481.","journal-title":"Respir Med"},{"issue":"1","key":"key20251218142127_B20","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-021-03784-2","article-title":"Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals","volume":"25","author":"COVID-ICU group, for the REVA network, COVID-ICU investigators","year":"2021","unstructured":". COVID-ICU group, for the REVA network, COVID-ICU investigators. Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals. Crit Care. 2021;25(1):421.","journal-title":"Crit Care"},{"key":"key20251218142127_B21","doi-asserted-by":"crossref","DOI":"10.1177\/17534666221113663","article-title":"Comparison between high-flow nasal cannula and noninvasive ventilation in COVID-19 patients: a systematic review and meta-analysis","volume":"16","author":"Peng","year":"2022","unstructured":". Peng Y, Dai B, Zhao HW, Wang W, Kang J, Hou HJ, et al. Comparison between high-flow nasal cannula and noninvasive ventilation in COVID-19 patients: a systematic review and meta-analysis. Ther Adv Respir Dis. 2022;16:17534666221113663.","journal-title":"Ther Adv Respir Dis"},{"issue":"3","key":"key20251218142127_B22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.hrtlng.2021.02.009","article-title":"Impact of HFNC application on mortality and intensive care length of stay in acute respiratory failure secondary to COVID-19 pneumonia","volume":"50","author":"Sayan","year":"2021","unstructured":". Sayan I, Altinay M, \u00c7inar AS, T\u00fcrk HS, Peker N, Sahin K, et al. Impact of HFNC application on mortality and intensive care length of stay in acute respiratory failure secondary to COVID-19 pneumonia. Heart Lung. 2021;50(3):425-9.","journal-title":"Heart Lung"},{"issue":"8","key":"key20251218142127_B23","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4187\/respcare.09672","article-title":"Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients With COVID-19","volume":"67","author":"Garcia","year":"2022","unstructured":". Garcia MA, Johnson SW, Sisson EK, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Bogojevic M, Domecq JP, Lal A, Heavner S, Cheruku SR, Lee D, Anderson HL, Denson JL, Gajic O, Kashyap R, Walkey AJ; from the Society of Critical Care Medicine's Discovery Viral Infection and Respiratory Illness Universal Study Investigators. Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients With COVID-19. Respir Care. 2022;67(8):929-38.","journal-title":"Respir Care"},{"issue":"9","key":"key20251218142127_B24","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1164\/rccm.201605-0916OC","article-title":"Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure","volume":"195","author":"Mauri","year":"2017","unstructured":". Mauri T, Turrini C, Eronia N, Grasselli G, Volta CA, Bellani G, et al. Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure. Am J Respir Crit Care Med. 2017;195(9):1207-15.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"key20251218142127_B25","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.4187\/respcare.09987","article-title":"High-Flow Nasal Cannula Versus Noninvasive Ventilation in Patients With COVID-19","volume":"67","author":"Beran","year":"2022","unstructured":". Beran A, Srour O, Malhas SE, Mhanna M, Ayesh H, Sajdeya O, et al. High-Flow Nasal Cannula Versus Noninvasive Ventilation in Patients With COVID-19. Respir Care. 2022;67(9):1177-89.","journal-title":"Respir Care"},{"issue":"6","key":"key20251218142127_B26","doi-asserted-by":"crossref","first-page":"R269","DOI":"10.1186\/cc13103","article-title":"Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors","volume":"17","author":"Thille","year":"2013","unstructured":". Thille AW, Contou D, Fragnoli C, C\u00f3rdoba-Izquierdo A, Boissier F, Brun-Buisson C. Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. Crit Care. 2013;17(6):R269-269.","journal-title":"Crit Care"},{"key":"key20251218142127_B27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ajem.2020.07.071","article-title":"Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study","volume":"46","author":"Duan","year":"2021","unstructured":". Duan J, Chen B, Liu X, Shu W, Zhao W, Li J, et al. Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study. Am J Emerg Med. 2021;46:276-81.","journal-title":"Am J Emerg Med"},{"issue":"1","key":"key20251218142127_B28","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-021-00825-5","article-title":"High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study","volume":"11","author":"Bonnet","year":"2021","unstructured":". Bonnet N, Martin O, Boubaya M, Levy V, Ebstein N, Karoubi P, et al. High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study. Ann Intensive Care. 2021;11(1):37.","journal-title":"Ann Intensive Care"},{"key":"key20251218142127_B29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.47066\/2177-9333.AC20.covid19.010","article-title":"Indica\u00e7\u00e3o e uso da ventila\u00e7\u00e3o n\u00e3o-invasiva e da c\u00e2nula nasal de alto fluxo, e orienta\u00e7\u00f5es sobre manejo da ventila\u00e7\u00e3o mec\u00e2nica invasiva no tratamento da insufici\u00eancia respirat\u00f3ria aguda na COVID-19","volume":"11","author":"Martinez","year":"2020","unstructured":". Martinez BP, Andrade FM, Roncalli A, Martins JA, Ribeiro DC, Pianezzola EM, et al Indica\u00e7\u00e3o e uso da ventila\u00e7\u00e3o n\u00e3o-invasiva e da c\u00e2nula nasal de alto fluxo, e orienta\u00e7\u00f5es sobre manejo da ventila\u00e7\u00e3o mec\u00e2nica invasiva no tratamento da insufici\u00eancia respirat\u00f3ria aguda na COVID-19. Assobrafir Cienc. 2020;11(Suppl 1):101-10.","journal-title":"Assobrafir Cienc"},{"issue":"4","key":"key20251218142127_B30","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.chest.2017.01.004","article-title":"Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation? A systematic review and meta-analysis","volume":"151","author":"Ni","year":"2017","unstructured":". Ni YN, Luo J, Yu H, Liu D, Ni Z, Cheng J, et al. Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation? A systematic review and meta-analysis. Chest. 2017;151(4):764-75.","journal-title":"Chest"},{"issue":"3","key":"key20251218142127_B31","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-067879","article-title":"High-flow nasal cannula reduces intubation rate in patients with COVID-19 with acute respiratory failure: a meta-analysis and systematic review","volume":"13","author":"Li","year":"2023","unstructured":". Li Y, Li C, Chang W, Liu L. High-flow nasal cannula reduces intubation rate in patients with COVID-19 with acute respiratory failure: a meta-analysis and systematic review. BMJ Open. 2023;13(3):e067879.","journal-title":"BMJ Open"},{"issue":"1","key":"key20251218142127_B32","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-020-03314-6","article-title":"Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study","volume":"24","author":"Ferrando","year":"2020","unstructured":". Ferrando C, Mellado-Artigas R, Gea A, Arruti E, Aldecoa C, Adalia R, Ramasco F, Monedero P, Maseda E, Tamayo G, Hern\u00e1ndez-Sanz ML, Mercadal J, Mart\u00edn-Grande A, Kacmarek RM, Villar J, Su\u00e1rez-Sipmann F; COVID-19 Spanish ICU Network. Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study. Crit Care. 2020;24(1):597.","journal-title":"Crit Care"},{"issue":"2","key":"key20251218142127_B33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.23736\/S0026-4806.20.06952-9","article-title":"Continuous positive airway pressure and pronation outside the intensive care unit in COVID 19 ARDS","volume":"113","author":"Ramirez","year":"2022","unstructured":". Ramirez GA, Bozzolo EP, Castelli E, Marinosci A, Angelillo P, Damanti S, et al. Continuous positive airway pressure and pronation outside the intensive care unit in COVID 19 ARDS. Minerva Med. 2022;113(2):281-90.","journal-title":"Minerva Med"},{"issue":"1","key":"key20251218142127_B34","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-021-03469-w","article-title":"High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure","volume":"25","author":"Mellado-Artigas","year":"2021","unstructured":". Mellado-Artigas R, Ferreyro BL, Angriman F, Hern\u00e1ndez-Sanz M, Arruti E, Torres A, Villar J, Brochard L, Ferrando C; COVID-19 Spanish ICU Network. High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care. 2021;25(1):58.","journal-title":"Crit Care"},{"issue":"10","key":"key20251218142127_B35","article-title":"The Use of High-Flow Nasal Oxygen in the ICU as a First-Line Therapy for Acute Hypoxemic Respiratory Failure Secondary to Coronavirus Disease 2019","volume":"2","author":"McDonough","year":"2020","unstructured":". McDonough G, Khaing P, Treacy T, McGrath C, Yoo EJ. The Use of High-Flow Nasal Oxygen in the ICU as a First-Line Therapy for Acute Hypoxemic Respiratory Failure Secondary to Coronavirus Disease 2019. Crit Care Explor. 2020;2(10):e0257.","journal-title":"Crit Care Explor"},{"issue":"7","key":"key20251218142127_B36","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1164\/rccm.202005-2007LE","article-title":"High-Flow Nasal Cannula in Critically III Patients with Severe COVID-19","author":"Demoule","year":"2020","unstructured":". Demoule A, Vieillard Baron A, Darmon M, Beurton A, G\u00e9ri G, Voiriot G, et al. High-Flow Nasal Cannula in Critically III Patients with Severe COVID-19. Am J Respir Crit Care Med. 2020;202(7):1039-42.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"key20251218142127_B37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2991\/jegh.k.200817.001","article-title":"Helmet Continuous Positive Airway Pressure in the Treatment of COVID-19 Patients with Acute Respiratory Failure could be an Effective Strategy: A Feasibility Study","volume":"10","author":"Alharthy","year":"2020","unstructured":". Alharthy A, Faqihi F, Noor A, Soliman I, Brindley PG, Karakitsos D, et al. Helmet Continuous Positive Airway Pressure in the Treatment of COVID-19 Patients with Acute Respiratory Failure could be an Effective Strategy: A Feasibility Study. J Epidemiol Glob Health. 2020;10(3):201-3.","journal-title":"J Epidemiol Glob Health"},{"issue":"9","key":"key20251218142127_B38","article-title":"Early Clinical Experience in Using Helmet Continuous Positive Airway Pressure and High-Flow Nasal Cannula in Overweight and Obese Patients With Acute Hypoxemic Respiratory Failure From Coronavirus Disease 2019","volume":"2","author":"Gaulton","year":"2020","unstructured":". Gaulton TG, Bellani G, Foti G, Frazer MJ, Fuchs BD, Cereda M. Early Clinical Experience in Using Helmet Continuous Positive Airway Pressure and High-Flow Nasal Cannula in Overweight and Obese Patients With Acute Hypoxemic Respiratory Failure From Coronavirus Disease 2019. Crit Care Explor. 2020;2(9):e0216.","journal-title":"Crit Care Explor"},{"issue":"4","key":"key20251218142127_B39","doi-asserted-by":"crossref","first-page":"979","DOI":"10.5811\/westjem.2021.3.50116","article-title":"Emergency department-initiated high-flow nasal cannula for COVID-19 respiratory distress","volume":"22","author":"Jarou","year":"2021","unstructured":". Jarou ZJ, Beiser DG, Sharp WW, Chacko R, Goode D, Rubin DS, et al. Emergency department-initiated high-flow nasal cannula for COVID-19 respiratory distress. West J Emerg Med. 2021;22(4):979-87.","journal-title":"West J Emerg Med"},{"issue":"2","key":"key20251218142127_B40","first-page":"949","article-title":"Feasibility of non-rebreather masks and nasal cannula as a substitute for high flow nasal oxygen in patients with severe COVID-19 infection","volume":"37","author":"Kabak","year":"2021","unstructured":". Kabak M, \u00c7il B. Feasibility of non-rebreather masks and nasal cannula as a substitute for high flow nasal oxygen in patients with severe COVID-19 infection. Acta Med Mediter. 2021;37(2):949-54.","journal-title":"Acta Med Mediter"},{"issue":"6","key":"key20251218142127_B41","first-page":"708","article-title":"Effect of noninvasive positive pressure ventilation and high-flow nasal cannula oxygen therapy on the clinical efficacy of coronavirus disease 2019 patients with acute respiratory distress syndrome","volume":"33","author":"Zhao","year":"2021","unstructured":". Zhao Z, Cao H, Cheng Q, Li N, Zhang S, Ge Q, Shen N, Yang L, Shi W, Bai J, Meng Q, Wu C, Wang B, Li Q, Yao G. [Effect of noninvasive positive pressure ventilation and high-flow nasal cannula oxygen therapy on the clinical efficacy of coronavirus disease 2019 patients with acute respiratory distress syndrome]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021;33(6):708-13. Chinese.","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"1","key":"key20251218142127_B42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pulmoe.2021.09.002","article-title":"Outcomes of COVID-19 patients treated with noninvasive respiratory support outside-ICU setting: a Portuguese reality","volume":"28","author":"Rodrigues Santos","year":"2022","unstructured":". Rodrigues Santos L, Gon\u00e7alves Lopes R, Rocha AS, Martins MD, Guimar\u00e3es TC, Meireles M, et al. Outcomes of COVID-19 patients treated with noninvasive respiratory support outside-ICU setting: a Portuguese reality. Pulmonology. 2022;28(1):59-61.","journal-title":"Pulmonology"},{"issue":"1","key":"key20251218142127_B43","doi-asserted-by":"crossref","DOI":"10.1186\/s43168-021-00063-0","article-title":"High flow nasal cannula oxygen and non-invasive mechanical ventilation in management of COVID-19 patients with acute respiratory failure: a retrospective observational study","volume":"15","author":"Shoukri","year":"2021","unstructured":". Shoukri AM. High flow nasal cannula oxygen and non-invasive mechanical ventilation in management of COVID-19 patients with acute respiratory failure: a retrospective observational study. Egypt J Bronchol. 2021;15(1):17.","journal-title":"Egypt J Bronchol"},{"key":"key20251218142127_B44","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2022.103842","article-title":"Noninvasive ventilation and high-flow nasal cannula in patients with acute hypoxemic respiratory failure by covid-19: A retrospective study of the feasibility, safety and outcomes","volume":"298","author":"Costa","year":"2022","unstructured":". Costa WN, Miguel JP, Prado FD, Lula LH, Amarante GA, Righetti RF, et al. Noninvasive ventilation and high-flow nasal cannula in patients with acute hypoxemic respiratory failure by covid-19: A retrospective study of the feasibility, safety and outcomes. Respir Physiol Neurobiol. 2022;298:103842.","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"key20251218142127_B45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13054-022-03905-5","article-title":"Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study","volume":"26","author":"Wendel-Garcia","year":"2022","unstructured":". Wendel-Garcia PD, Mas A, Gonz\u00e1lez-Isern C, Ferrer R, M\u00e1\u00f1ez R, Masclans JR, Sandoval E, Vera P, Trenado J, Fern\u00e1ndez R, Sirvent JM, Mart\u00ednez M, Ibarz M, Garro P, Lopera JL, Bod\u00ed M, Y\u00e9benes-Reyes JC, Triginer C, Vallverd\u00fa I, Bar\u00f3 A, Bod\u00ed F, Saludes P, Valencia M, Roche-Campo F, Huerta A, Cambra FJ, Barber\u00e0 C, Echevarria J, Pe\u00f1uelas \u00d3, Mancebo J; UCIsCAT study group. Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study. Crit Care. 2022;26(1):37.","journal-title":"Crit Care"},{"key":"key20251218142127_B46","article-title":"High-flow nasal oxygen therapy decrease the risk of mortality and the use of invasive mechanical ventilation in patients with severe SARS-CoV-2 pneumonia? A retrospective and comparative study of 265 cases","volume":"74","author":"Alkouh","year":"2022","unstructured":". Alkouh R, El Rhalete A, Manal M, Ghizlane EA, Samia B, Salma T, et al. High-flow nasal oxygen therapy decrease the risk of mortality and the use of invasive mechanical ventilation in patients with severe SARS-CoV-2 pneumonia? A retrospective and comparative study of 265 cases. Ann Med Surg (Lond). 2022;74:103230.","journal-title":"Ann Med Surg (Lond)"},{"issue":"4","key":"key20251218142127_B47","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s11739-020-02548-0","article-title":"Clinical characteristics and respiratory support of 310 COVID-19 patients, diagnosed at the emergency room: a single-center retrospective study","volume":"16","author":"Di Domenico","year":"2021","unstructured":". Di Domenico SL, Coen D, Bergamaschi M, Albertini V, Ghezzi L, Cazzaniga MM, et al. Clinical characteristics and respiratory support of 310 COVID-19 patients, diagnosed at the emergency room: a single-center retrospective study. Intern Emerg Med. 2021;16(4):1051-60.","journal-title":"Intern Emerg Med"},{"key":"key20251218142127_B48","article-title":"University Hospital Southampton Critical Care Team; REACT COVID Investigator. Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre","volume":"9","author":"Burton","year":"2020","unstructured":". Burton PH, Jackson AI, Beecham R, Ferrari M, Nasim MM, Grocott MP, et al. University Hospital Southampton Critical Care Team; REACT COVID Investigator. Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre. F1000 Res. 2020;9:859.","journal-title":"F1000 Res"},{"issue":"6","key":"key20251218142127_B49","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4187\/respcare.08631","article-title":"High-Flow Nasal Cannula Therapy in COVID-19: Using the ROX Index to Predict Success","volume":"66","author":"Chandel","year":"2021","unstructured":". Chandel A, Patolia S, Brown AW, Collins AC, Sahjwani D, Khangoora V, et al. High-Flow Nasal Cannula Therapy in COVID-19: Using the ROX Index to Predict Success. Respir Care. 2021;66(6):909-19.","journal-title":"Respir Care"},{"issue":"11","key":"key20251218142127_B50","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1136\/thoraxjnl-2020-214993","article-title":"High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection","volume":"75","author":"Vianello","year":"2020","unstructured":". Vianello A, Arcaro G, Molena B, Turato C, Sukthi A, Guarnieri G, et al. High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection. Thorax. 2020;75(11):998-1000.","journal-title":"Thorax"},{"issue":"3","key":"key20251218142127_B51","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1097\/CCM.0000000000005309","article-title":"The effectiveness of high-flow nasal cannula in coronavirus disease 2019 pneumonia: a retrospective cohort study","volume":"50","author":"Burnim","year":"2022","unstructured":". Burnim MS, Wang K, Checkley W, Nolley EP, Xu Y, Garibaldi BT. The effectiveness of high-flow nasal cannula in coronavirus disease 2019 pneumonia: a retrospective cohort study. Crit Care Med. 2022;50(3):e253-62.","journal-title":"Crit Care Med"},{"issue":"2","key":"key20251218142127_B52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.aucc.2020.10.009","article-title":"Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany","volume":"34","author":"Roedl","year":"2021","unstructured":". Roedl K, Jarczak D, Thasler L, Bachmann M, Schulte F, Bein B, et al. Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany. Aust Crit Care. 2021;34(2):167-75.","journal-title":"Aust Crit Care"},{"key":"key20251218142127_B53","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2020.103489","article-title":"Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2","volume":"280","author":"Pagano","year":"2020","unstructured":". Pagano A, Porta G, Bosso G, Allegorico E, Serra C, Dello Vicario F, et al. Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2. Respir Physiol Neurobiol. 2020;280:103489.","journal-title":"Respir Physiol Neurobiol"},{"key":"key20251218142127_B54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ajem.2021.01.068","article-title":"Non-invasive positive pressure ventilation versus endotracheal intubation in treatment of COVID-19 patients requiring ventilatory support","volume":"43","author":"Daniel","year":"2021","unstructured":". Daniel P, Mecklenburg M, Massiah C, Joseph MA, Wilson C, Parmar P, et al. Non-invasive positive pressure ventilation versus endotracheal intubation in treatment of COVID-19 patients requiring ventilatory support. Am J Emerg Med. 2021;43:103-8.","journal-title":"Am J Emerg Med"},{"issue":"12","key":"key20251218142127_B55","doi-asserted-by":"crossref","first-page":"734","DOI":"10.12788\/jhm.3548","article-title":"Safety Assessment of a Noninvasive Respiratory Protocol for Adults With COVID-19","volume":"15","author":"Soares","year":"2020","unstructured":". Soares WE 3rd, Schoenfeld EM, Visintainer P, Elia T, Medarametla V, Schoenfeld DA, et al. Safety Assessment of a Noninvasive Respiratory Protocol for Adults With COVID-19. J Hosp Med. 2020;15(12):734-8.","journal-title":"J Hosp Med"},{"key":"key20251218142127_B56","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100419","article-title":"Severity of respiratory failure and outcome of patients needing a ventilatory support in the Emergency Department during Italian novel coronavirus SARS-CoV2 outbreak: Preliminary data on the role of Helmet CPAP and Non-Invasive Positive Pressure Ventilation","volume":"24","author":"Duca","year":"2020","unstructured":". Duca A, Memaj I, Zanardi F, Preti C, Alesi A, Della Bella L, et al. Severity of respiratory failure and outcome of patients needing a ventilatory support in the Emergency Department during Italian novel coronavirus SARS-CoV2 outbreak: Preliminary data on the role of Helmet CPAP and Non-Invasive Positive Pressure Ventilation. EClinicalMedicine. 2020;24:100419.","journal-title":"EClinicalMedicine"},{"issue":"1","key":"key20251218142127_B57","doi-asserted-by":"crossref","DOI":"10.1016\/j.opresp.2020.100081","article-title":"Todos los caminos llevan a Roma: resultados de las terapias respiratorias no invasivas aplicadas en un centro terciario sin Unidad de Cuidados Intermedios durante la pandemia de COVID-19","volume":"3","author":"L\u00f3pez-Padilla","year":"2021","unstructured":". L\u00f3pez-Padilla D, Ter\u00e1n Tinedo JR, L\u00f3pez-Mart\u00edn S, Caballero Segura FJ, Gallo Gonz\u00e1lez V, Recio Moreno B, et al. Todos los caminos llevan a Roma: resultados de las terapias respiratorias no invasivas aplicadas en un centro terciario sin Unidad de Cuidados Intermedios durante la pandemia de COVID-19. Open Respir Arch. 2021;3(1):100081.","journal-title":"Open Respir Arch"},{"key":"key20251218142127_B58","article-title":"A multicomponent oxygen delivery strategy for COVID-19 patients in a step-down intensive care unit: a case series","volume":"31","author":"Giron","year":"2020","unstructured":". Giron F, Rao S, Tapaskar N. A multicomponent oxygen delivery strategy for COVID-19 patients in a step-down intensive care unit: a case series. Respir Med Case Rep. 2020;31:101209.","journal-title":"Respir Med Case Rep"}],"container-title":["einstein (S\u00e3o Paulo)"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:21:41Z","timestamp":1766067701000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.einstein.br\/article\/effect-of-non-invasive-ventilation-and-high-flow-nasal-cannula-on-hospital-mortality-in-covid-19-induced-acute-respiratory-failure-a-meta-analysis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":58,"alternative-id":["10.31744\/einstein_journal\/2026RW0695"],"URL":"https:\/\/doi.org\/10.31744\/einstein_journal\/2026rw0695","relation":{},"ISSN":["1679-4508","2317-6385"],"issn-type":[{"value":"1679-4508","type":"print"},{"value":"2317-6385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"eRW0695"}}