{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:26:34Z","timestamp":1782807994195,"version":"3.54.5"},"reference-count":21,"publisher":"Center for Academic Publications Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol","J Nutr Sci Vitaminol","JNSV"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3177\/jnsv.61.175","type":"journal-article","created":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T22:01:51Z","timestamp":1433714511000},"page":"175-181","source":"Crossref","is-referenced-by-count":33,"title":["Acute and Subacute Toxicity Studies on Rutin-Rich Tartary Buckwheat Dough in Experimental Animals"],"prefix":"10.3177","volume":"61","author":[{"given":"Tatsuro","family":"SUZUKI","sequence":"first","affiliation":[{"name":"National Agriculture and Food Research Organization Hokkaido Agricultural Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"MORISHITA","sequence":"additional","affiliation":[{"name":"National Agriculture and Food Research Organization Hokkaido Agricultural Research Center, Memuro Upland Farming Research Station"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"NODA","sequence":"additional","affiliation":[{"name":"National Agriculture and Food Research Organization Hokkaido Agricultural Research Center, Memuro Upland Farming Research Station"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"ISHIGURO","sequence":"additional","affiliation":[{"name":"National Agriculture and Food Research Organization Hokkaido Agricultural Research Center, Memuro Upland Farming Research Station"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1759","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Sando C, Lloyd J. 1924. The isolation and identification of rutin from the flowers of elder (<i>Sambucus canadensis <\/i>L.). J Biol Chem 58: 737-745.","DOI":"10.1016\/S0021-9258(18)85333-9"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Couch J, Naghski J, Krewson C. 1946. Buckwheat as a source of rutin. Science 103: 197-198.","DOI":"10.1126\/science.103.2668.197"},{"key":"3","unstructured":"3) Haley T, Bassin M. 1951. The isolation, purification and derivatives of plant pigments related to rutin. J Am Pharmaceut Assoc Sci Ed 40: 111-112."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Fabjan N, Rode J, Kosir I. 2003. Tartary buckwheat (<i>Fagopyrum tataricum<\/i> Gaertn.) as a source of dietary rutin and quercitrin. J Agric Food Chem 51: 6452-6455.","DOI":"10.1021\/jf034543e"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Griffith JQ, Couch JF, Lindauer A. 1944. Effect of rutin on increased capillary fragility in man. Proc Soc Exp Biol Med 55: 228-229.","DOI":"10.3181\/00379727-55-14532"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Shanno R. 1946. Rutin: A new drug for the treatment of increased capillary fragility. Am J Med Sci 211: 539-543.","DOI":"10.1097\/00000441-194605000-00003"},{"key":"7","unstructured":"7) Jiang P, Burczynski F, Campbell C. 2007. Rutin and flavonoid contents in three buckwheat species <i>Fagopyrum esculentum<\/i>, <i>F-tataricum<\/i>, and <i>F-homotropicum<\/i> and their protective effects against lipid peroxidation. Food Res Int 40: 356-364."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Awatsuhara R, Harada K, Maeda T. 2010. Antioxidative activity of the buckwheat polyphenol rutin in combination with ovalbumin. Molecular Med Rep 3: 121-125.","DOI":"10.3892\/mmr_00000228"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Matsubara Y, Kumamoto M, Iizuka Y, Murakami K, Okamoto H, Miyake H, Yokoi K. 1985. Structure and hypotensive effect of flavonoid glycosides in <i>Citrus unshiu<\/i> peelings. Agric Biol Chem 49: 909-914.","DOI":"10.1271\/bbb1961.49.909"},{"key":"10","unstructured":"10) Li YQ, Zhou FC, Gao F. 2009. Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. J Agric Food Chem 57: 11463-11468."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Wieslander G, Fabjan N, Vogrincic M, Kreft I, Janson C, Spetz-Nystr&ouml;m U, Vombergar B, Tagesson C, Leanderson P, Norb&auml;ck D. 2011. Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: A double blind crossover study in day-care center staffs. Tohoku J Exp Med 225: 123-130.","DOI":"10.1620\/tjem.225.123"},{"key":"12","unstructured":"12) Kitabayashi H, Ujihara A, Hirose T, Minami M. 1995. On the genotypic differences for rutin content in tartary buckwheat, Fagopyrum tataricum Gaertn. Breeding Sci 45: 189-194."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kreft I, Fabjan N, Yasumoto K. 2006. Rutin content in buckwheat (<i>Fagopyrum esculentum<\/i> Moench) food materials and products. Food Chem 98: 508-512.","DOI":"10.1016\/j.foodchem.2005.05.081"},{"key":"14","unstructured":"14) Ikeda K, Ikeda S, Kreft I, Rufa L. 2012. Utilization of Tartary buckwheat. Fagopyrum 29: 27-30."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yasuda T, Masaki K, Kashiwagi T. 1992. An enzyme degrading rutin in Tartary buckwheat seeds. J Jpn Soc Food Sci Technol 39: 994-1000.","DOI":"10.3136\/nskkk1962.39.994"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Yasuda T, Nakagawa H. 1994. Purification and characterization of rutin-degrading enzymes in Tartary buckwheat seeds. Phytochemistry 37: 133-136.","DOI":"10.1016\/0031-9422(94)85012-7"},{"key":"17","unstructured":"17) Suzuki T, Honda Y, Funatsuki W, Nakatsuka K. 2002. Purification and characterization of flavonol 3-glucosidase, and its activity during ripening in Tartary buckwheat seeds. Plant Sci 163: 417-423."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Suzuki T, Morishita T, Mukasa Y, Takigawa S, Yokota S, Ishiguro K, Noda T. 2014. Discovery and genetic analysis of non-bitter Tartary buckwheat (<i>Fagopyrum tataricum<\/i> Gaertn.) with trace rutinosidase activity. Breeding Sci 64: 339-343.","DOI":"10.1270\/jsbbs.64.339"},{"key":"19","unstructured":"19) Suzuki T, Morishita T, Mukasa Y, Takigawa S, Yokota S, Ishiguro K, Noda T. 2014. Breeding of &lsquo;Manten-Kirari,&rsquo; a non-bitter and trace-rutinosidase variety of Tartary buckwheat (Fagopyrum tataricum Gaertn.) Breeding Sci 64: 344-350."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Wilson RH, Moratarotti T, Doxtader E. 1947. Toxicity studies on rutin. Exp Biol Med 64: 324-327.","DOI":"10.3181\/00379727-64-15781"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Suzuki T, Honda Y, Funatsuki E, Nakatsuka K. 2004. In-gel detection and study of the role of flavonol 3-glucosidase in the bitter taste generation in tartary buckwheat. J Sci Food Agric 84: 1691-1694.","DOI":"10.1002\/jsfa.1865"}],"container-title":["Journal of Nutritional Science and Vitaminology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T20:02:31Z","timestamp":1652299351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/61\/2\/61_175\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3177\/jnsv.61.175","relation":{},"ISSN":["0301-4800","1881-7742"],"issn-type":[{"value":"0301-4800","type":"print"},{"value":"1881-7742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}