{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:21:14Z","timestamp":1782570074997,"version":"3.54.5"},"reference-count":53,"publisher":"Center for Academic Publications Japan","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol","J Nutr Sci Vitaminol","JNSV"],"published-print":{"date-parts":[[2015]]},"DOI":"10.3177\/jnsv.61.382","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T22:03:26Z","timestamp":1449180206000},"page":"382-390","source":"Crossref","is-referenced-by-count":33,"title":["Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats"],"prefix":"10.3177","volume":"61","author":[{"given":"Takako","family":"SUZUKI","sequence":"first","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"KAJITA","sequence":"additional","affiliation":[{"name":"Department of Food Sciences, College of Life Science, Ibaraki Christian University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"KATSUMATA","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"MATSUZAKI","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuharu","family":"SUZUKI","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1759","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Tapiero H, Tew KD. 2003. Trace elements in human physiology and pathology: zinc and metallothineins. Biomed Pharmacother 57: 399-411.","DOI":"10.1016\/S0753-3322(03)00081-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Prasad AS. 1991. Discovery of human zinc deficiency and studies in an experimental human model. Am J Clin Nutr 53: 403-412.","DOI":"10.1093\/ajcn\/53.2.403"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Grynpas MD, Pritzker KPH, Hancock RG. 1987. Neutron activation of bulk and selected trace elements in bone using a low flux SLOWPOKE reactor. Biol Trace Elem Res 13: 333-344.","DOI":"10.1007\/BF02796644"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Holloway WR, Collier FM, Herbst RE, Hodge JM, Nicholson GC. 1996. Osteoblast-mediated effects of zinc on isolated rat osteoclast: Inhibition of bone resorption and enhancement of osteoclast number. Bone 19: 137-142.","DOI":"10.1016\/8756-3282(96)00141-X"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Moonga BS, Dempster DW. 1995. Zinc is a potent inhibitor of osteoclastic bone resorption in vitro. J Bone Miner Res Official J Am Soc Bone Miner Res 10: 453-457.","DOI":"10.1002\/jbmr.5650100317"},{"key":"6","unstructured":"6) Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS. 2010. Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells. Nutr Res Pract 4: 356-361."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Togari A, Arakawa S, Arai M, Matsumoto S. 1993. Alteration of in vitro bone metabolism and tooth formation by zinc. Gen Pharmacol 24: 1133-1140.","DOI":"10.1016\/0306-3623(93)90360-A"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Calhoun NR, Smith JC Jr, Becker KL. 1975. The effects of zinc on ectopic bone formation. Oral Surg Oral Med Oral Pathol 39: 698-706.","DOI":"10.1016\/0030-4220(75)90029-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Harada S, Rodan GA. 2003. Control of osteoblast function and regulation of bone mass. Nature 423: 349-355.","DOI":"10.1038\/nature01660"},{"key":"10","unstructured":"10) Noda M. 1993. Cellular and molecular biology of bone. In: Molecular Mechanisms Mediating Developmental and Hormone-Regulated Expression of Genes in Osteoblasts: An Integrated Relationship of Cell Growth and Differentiation (Stein GS, Lian JB, eds), p 48-97. Academic Press, San Diego."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Boyle WJ, Simonet WS, Lacey DL. 2003. Osteoclast differentiation and activation. Nature 423: 337-342.","DOI":"10.1038\/nature01658"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH. 2001. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344: 1434-1441.","DOI":"10.1056\/NEJM200105103441904"},{"key":"13","unstructured":"13) Takahashi N. 2013. Mechanism of inhibitory action of Eldecalcitol, an active vitamin D analog, on bone resorption in vivo. J Steroid Biochem Mol Biol 136: 171-174."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, Jurutka PW. 2013. Molecular mechanisms of vitamin D action. Calcif Tissue Int 92: 77-98.","DOI":"10.1007\/s00223-012-9619-0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Brzóska MM, Moniuszko-Jakoniuk J. 2001. Interactions between cadmium and zinc in the organism. Food Chem Toxicol 29: 967-980.","DOI":"10.1016\/S0278-6915(01)00048-5"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Bonner FW, King LJ, Parke DV. 1980. Cadmium-induced reduction bone alkaline phosphatase and its prevention by zinc. Chem Biol Interact 29: 369-372.","DOI":"10.1016\/0009-2797(80)90155-6"},{"key":"17","unstructured":"17) Valberg LS, Flanagan PR, Chamberlain MJ. 1984. Effects of iron, tin and copper on zinc absorption in humans. Am J Clin Nutr 40: 536-541."},{"key":"18","unstructured":"18) Greger JL, Zaikis SC, Abernathy RP, Bennett OA, Huffman J. 1978. Zinc, nitrogen, copper, iron and manganese balance in adolescent females fed two levels of zinc. J Nutr 108: 1449-1456."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Van Campen DR, Scaife PU. 1967. Zinc interference with copper absorption in rats. J Nutr 91: 473-476.","DOI":"10.1093\/jn\/91.4.473"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Nielsen FH. 2009. Marginal zinc deficiency increases magnesium retention and impairs calcium utilization in rats. Biol Trace Elem Res 128: 220-231.","DOI":"10.1007\/s12011-008-8268-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Dursun N, Aydogan S. 1994. Comparative effects of calcium deficiency and supplements on the intestinal absorption of zinc in rats. Jpn J Physiol 44: 157-166.","DOI":"10.2170\/jjphysiol.44.157"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Planells E, Aranda P, Lerma A, Llopis J. 1994. Changes in bioavailability and tissue distribution of zinc caused by magnesium deficiency in rats. Br J Nutr 72: 315-323.","DOI":"10.1079\/BJN19940032"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Hurley LS, Gowan J, Mihaud G. 1969. Calcium metabolism in manganese-deficient and zinc-deficient rats. Proc Soc Exp Biol Med 130: 856-860.","DOI":"10.3181\/00379727-130-33672"},{"key":"24","unstructured":"24) Salgueiro MJ, Torti H, Meseri E, Weill R, Orlandini J, Urriza R, Zubillaga M, Janjetic M, Barrado A, Boccio J. 2006. Dietary zinc effects on zinc, calcium, and magnesium content in bones of growing rats. Biol Trace Elem Res 110: 73-78."},{"key":"25","unstructured":"25) Windisch W, Wher U, Rambeck W, Erben R.. 2002. Effect of Zn deficiency and subsequent Zn repletion on bone mineral composition and markers of bone tissue metabolism in 65 Zn-labelled, young-adult rats. J Anim Physiol Anim Nutr (Berl) 86: 214-221."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Reeves PG, Nielsen FH, Fahey GC. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.","DOI":"10.1093\/jn\/123.11.1939"},{"key":"27","unstructured":"27) Gimblet EG, Marney AF, Bonses RW. 1967. Determination of calcium and magnesium in serum urine, diets and stool by atomic absorption spectrophotometry. Clin Chem 13: 204-214."},{"key":"28","unstructured":"28) Gomori G. 1942. A modification of the colorimetric phosphorus determination for use with the photoelectric colorimeter. J Lab Clin Med 27: 955-960."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Bouglé DL, Sabatier JP, Guaydier-Souquières G, Guillon-Metz F, Laroche D, Jauzac P, Bureau F. 2004. Zinc status and bone mineralization in adolescent girls. J Trace Elem Med Biol 18: 17-21.","DOI":"10.1016\/j.jtemb.2004.03.001"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Elmstachl S, Gullberg, Janzon L, Johnell O, Elmstahl B. 1998. Increased incidence of fractures in middle-aged and elderly men with low intake of phosphorus and zinc. Osteoporos Int 8: 333-340.","DOI":"10.1007\/s001980050072"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Hyun TH, Barret-Connor E, Milne DB. 2004. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. Am J Clin Nutr 80: 715-721.","DOI":"10.1093\/ajcn\/80.3.715"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Peretz A, Papadopoulos T, Willems D, Hotimsky A, Michiels N, Siderova V, Bergmann P, Neve J. 2001. Zinc supplementation increases bone alkaline phosphatase in healthy men. J Trace Elem Med Biol 15: 175-178.","DOI":"10.1016\/S0946-672X(01)80063-8"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Cho YE, Lomeda RA, Ryu SH, Sohn HY, Shin HI, Beattie JH, Kwun IS. 2007. Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats. Nutr Res Pract 2: 113-119.","DOI":"10.4162\/nrp.2007.1.2.113"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Virgili F, Canali R, Figus E, Vignolini F, Nobili F, Mengheri E. 1999. Intestinal damage induced by zinc deficiency is associated with enhanced CuZn superoxide dismutase activity in rats. Effect of dexamethasone or thyroxine treatment. Free Radic Biol Med 26: 1194-1201.","DOI":"10.1016\/S0891-5849(98)00307-4"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Brown JP, Delmas PD, Malaval L, Chapuy MC, Delmas PD, Edouard C, Meunier PJ. 1984. Serum bone gla protein: a specific marker for bone formation in post-menopausal osteoporosis. Lancet 1: 1091-1093.","DOI":"10.1016\/S0140-6736(84)92506-6"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Moss DW. 1992. Perspectives in alkaline phosphatase research. Clin Chem 38: 2486-2492.","DOI":"10.1093\/clinchem\/38.12.2486"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Hambidge KM, Casey CE, Krebs NF. 1986. Zinc. In: Trace Elements in Human and Animal Nutrition (Mertz W, ed), Vol 2, 5th ed, p 1-137. Academic Press, Orlando.","DOI":"10.1016\/B978-0-08-092469-4.50005-4"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Rossi L, Migliaccio S, Corsi A, Marzia M, Bianco P, Teti A, Gambelli L, Cianfarani S, Paoletti F, Branca F. 2001. Reduced growth and skeletal changes in zinc-deficient growing rats are due to impaired growth plate activity and inanition. J Nutr 131: 1142-1146.","DOI":"10.1093\/jn\/131.4.1142"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) MacDonald RS. 2000. The role of zinc in growth and cell proliferation. J Nutr 130: 1500S-1508S.","DOI":"10.1093\/jn\/130.5.1500S"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Kwun IS, Cho YE, Lomeda RA, Shin HI, Choi JY, Kang YH, Beattie JH. 2010. Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx2 modulation. Bone 46: 732-741.","DOI":"10.1016\/j.bone.2009.11.003"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C. 1994. Immunoassay for quantifying type I collagen degradation products in urine evaluated. Clin Chem 40: 2022-2025.","DOI":"10.1093\/clinchem\/40.11.2022"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Calabresi E, Lasagni L, Franceschelli F, de Lenonardis V, Becorpi A, Serio M, Brandi ML. 1994. Comparison of immune- and HPLC-assays for the measurement of urinary collagen cross-links. J Endocrinol Invest 17: 625-629.","DOI":"10.1007\/BF03349673"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Hosea HJ, Taylor CG, Wood T, Mollard R, Weiler HA. 2004. Zinc-deficient rats have more limited bone recovery during repletion than diet-restricted rats. Exp Biol Med (Maywood) 229: 303-311.","DOI":"10.1177\/153537020422900404"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Kawasaki I, Suzuki Y, Yanagisawa H. 2013. Zinc deficiency enhances the induction of micronuclei and 8-hydroxy-2′-deoxyguanosine via superoxide radical in bone marrow of zinc-deficient rats. Biol Trace Elem Res 154: 120-126.","DOI":"10.1007\/s12011-013-9706-8"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR. 1990. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85: 632-639.","DOI":"10.1172\/JCI114485"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Guo L, Hu X, Xu T, Qi X, Wan Y, Liu X, Jiang Y, Zhang L. 2011. Over-expression of Zip-13 mRNA in kidney and lung during dietary zinc deficiency in Wistar rats. Mol Biol Rep 38: 1869-1874.","DOI":"10.1007\/s11033-010-0304-y"},{"key":"47","unstructured":"47) Sun JY, Jing MY, Weng XY, Fu LJ, Xu ZR, Zi NT, Wang JF. 2005. Effects of dietary zinc levels on the activities of enzymes, weight of organs, and the concentrations of zinc and copper in growing rats. Biol Trace Elem Res 107: 153-165."},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Belluci MM, Schoenmaker T, Rossa-Junior C, Orrico SR, de Vries TJ, Everts V. 2013. Magnesium deficiency results in an increased formation of osteoclasts. J Nutr Biochem 24: 1488-1498.","DOI":"10.1016\/j.jnutbio.2012.12.008"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Rude RK, Gruber HE, Wei LY, Frausto A. 2005. Immunolocalization of RANKL is increased and OPG decreased during dietary magnesium deficiency in the rat. Nutr Metab (Lond) 2: 24.","DOI":"10.1186\/1743-7075-2-24"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Rude RK, Gruber HE, Norton HJ, Wei LY, Frausto A, Kilburn J. 2005. Dietary magnesium reduction to 25% of nutrient requirement disrupts bone and mineral metabolism in the rat. Bone 37: 211-219.","DOI":"10.1016\/j.bone.2005.04.005"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Yano K, Heilbrun LK, Wasnich RD, Hankin JH, Vogel JM. 1985. The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japanese American men and women living in Hawaii. Am J Clin Nutr 42: 877-888.","DOI":"10.1093\/ajcn\/42.5.877"},{"key":"52","unstructured":"52) Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. 1999. Potassium, magnesium and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69: 727-736."},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Aydin H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalin S. 2010. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res 133: 136-143.","DOI":"10.1007\/s12011-009-8416-8"}],"container-title":["Journal of Nutritional Science and Vitaminology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/61\/5\/61_382\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T06:21:03Z","timestamp":1599891663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/61\/5\/61_382\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.3177\/jnsv.61.382","relation":{},"ISSN":["0301-4800","1881-7742"],"issn-type":[{"value":"0301-4800","type":"print"},{"value":"1881-7742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}