{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:12:57Z","timestamp":1772849577793,"version":"3.50.1"},"reference-count":23,"publisher":"Center for Academic Publications Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci Vitaminol","JNSV","Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol","Journal of Nutritional Science and Vitaminology"],"published-print":{"date-parts":[[2019,12,31]]},"DOI":"10.3177\/jnsv.65.483","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T22:04:11Z","timestamp":1577743451000},"page":"483-490","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Long-Term Calcium Supplementation on Rats Bone Mineral Density and Cardiovascular Based on Metabonomics"],"prefix":"10.3177","volume":"65","author":[{"given":"Haining","family":"CHEN","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"HAO","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shucai","family":"YANG","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Basic Medical Science College, Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"LIU","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1759","reference":[{"key":"1","unstructured":"1) Peterlik M, K\u00e1llay E, Cross HS. 2013. Calcium nutrition and extracellular calcium sensing: Relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases. Nutrients 5: 302-327."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ma L, Li Y, Wang J, Zhu H, Yang W, Cao R, Qian Y, Feng M. 2015. Quality of life is related to social support in elderly osteoporosis patients in a Chinese population. PLoS One 10: e0127849.","DOI":"10.1371\/journal.pone.0127849"},{"key":"3","unstructured":"3) Zhang C-X, Chen Y-M, Chen W-Q, Su Y-X, Wang C-L, Wu J-N. 2012. Food group intake among adolescents in Guangzhou city compared with the Chinese dietary guidelines. Asia Pac J Clin Nutr 21(3): 450-456."},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) Chan R, Leung J, Woo J. 2013. A prospective cohort study examining the associations of dietary calcium intake with all-cause and cardiovascular mortality in older Chinese community-dwelling people. Dietary Calcium Intake and Mortality Nov 5. doi: 10.1371\/journal.pone.0080895.","DOI":"10.1371\/journal.pone.0080895"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Jorde R, Sundsfjord J, Fitzgerald P, B\u00f8naa KH. 1999. Serum calcium and cardiovascular risk factors and dieases. Hypertension 9: 484-490.","DOI":"10.1161\/01.HYP.34.3.484"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Reid IR, Bolland MJ, Avenell A, Grey A. 2011. Cardiovascular effects of calcium supplementation. Osteoporos Int 22(10): 1649-1658.","DOI":"10.1007\/s00198-011-1599-9"},{"key":"7","unstructured":"7) Kendrick J, Cheung AK, Kaufman JS, Greene T, Roberts WL, Smits G, Chonchol M. 2011. FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis. J Am Soc Nephrol 22: 1913-1922."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Bauer DC. 2013. Calcium supplements and fracture prevention. N Engl J Med 369: 1537-1543.","DOI":"10.1056\/NEJMcp1210380"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Shin CS, Kim KM. 2015. The risks and benefits of calcium supplementation. Endocrinol Metab 30: 27-34.","DOI":"10.3803\/EnM.2015.30.1.27"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Huang J-H, Tsai L-C, Chang Y-C, Cheng F-C. 2014. High or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes. Cardiovasc Diabetol Aug 1. doi: 10.1186\/s12933-014-0120-0.","DOI":"10.1186\/s12933-014-0120-0"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Goonewardena SN, Prevette LE, Desai AA. 2010. Metabolomics and atherosclerosis. Curr Atheroscler Rep 12(4): 267-272.","DOI":"10.1007\/s11883-010-0112-9"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Wang M, Yang X, Wang F, Li R, Ning H, Na L, Huang Y, Song Y, Liu L, Pan H, Zhang Q, Fan L, Li Y, Sun C. 2013. Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis. BMC Med Mar 28. doi: 10.1186\/1741-7015-11-86.","DOI":"10.1186\/1741-7015-11-86"},{"key":"13","unstructured":"13) Li J, Li H, Wang S. 2002. Effects of calcium supplementation on bone mineral accretion in adolescents. J Hygiene Res 31(5): 363-366 (in Chinese)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. 2007. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older. A meta-analysis. Lancet 370(9588): 657-666.","DOI":"10.1016\/S0140-6736(07)61342-7"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Michalsson K, Melhus H, Lemming EW, Wolk A, Byberg L. 2013. Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study. BMJ 346(2): 228-235.","DOI":"10.1136\/bmj.f228"},{"key":"16","unstructured":"16) Li ST, Na LX, Li Y, Gong L, Yuan F, Niu Y, Zhao Y, Sun C. 2013. Long-term calcium supplementation may have adverse effects on serum cholesterol and carotid intima-media thickness in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 98: 1353-1359."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Vo T-M, Disthabanchong S. 2014. Are there ways to attenuate arterial calcification and improve cardiovascular outcomes in chronic kidney diease? World Cardiol 6(5): 216-226.","DOI":"10.4330\/wjc.v6.i5.216"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Roseke WR. 1976. Noinvasive evaluation of ventricular hypertrophy in professional athletes. Circulation 53(2): 286.","DOI":"10.1161\/01.CIR.53.2.286"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Barry SP, Davidson SM, Townsend PA. 2008. Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol 40(10): 20-23.","DOI":"10.1016\/j.biocel.2008.02.020"},{"key":"20","doi-asserted-by":"crossref","unstructured":"21) Egom EE, Mamas MA, Chacko S. 2013. Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury. Frontiers Physiol 4: 1301-1310.","DOI":"10.3389\/fphys.2013.00130"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22) Miklosz A, Lukaszak B, Chabowski A, Rogowski F, Kurek K, Zendzian-Piotrowska M. 2015. Hyperthyroidism evokes myocardial ceramide accumulation. Cell Physiol Biochem 35: 755-766.","DOI":"10.1159\/000369735"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23) Wen F-Q, Jabbar AA, Patel DA, Kazarian T, Valentino LA. 1999. Atherosclerotic aortic gangliosides enhance integrin-mediated platelet adhesion to collagen. Arterioscler Thromb Vasc Biol 19: 519-525.","DOI":"10.1161\/01.ATV.19.3.519"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24) Seneff S, Davidson RM, Lauritzen A. 2015. A novel hypothesis for atherosclerosis as a cholesterol sulfate deficiency syndrome. Theor Biol Med Modelling Oct 9. doi: 10.1186\/s12976-015-0006-1.","DOI":"10.1186\/s12976-015-0006-1"}],"container-title":["Journal of Nutritional Science and Vitaminology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/65\/6\/65_483\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T05:41:23Z","timestamp":1578289283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/65\/6\/65_483\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,31]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.3177\/jnsv.65.483","relation":{},"ISSN":["0301-4800","1881-7742"],"issn-type":[{"value":"0301-4800","type":"print"},{"value":"1881-7742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,31]]}}}