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Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes. Cell Mol Life Sci 70: 1575-1595.","DOI":"10.1007\/s00018-013-1297-1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) De Blasio MJ, Gatford KL, Harland ML, Robinson JS, Owens JA. 2012. Placental restriction reduces insulin sensitivity and expression of insulin signaling and glucose transporter genes in skeletal muscle, but not liver, in young sheep. Endocrinology 153: 2142-2151.","DOI":"10.1210\/en.2011-1955"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Somm E, Vauthay DM, Guerardel A, Toulotte A, Cettour-Rose P, Klee P, Meda P, Aubert ML, H\u00fcppi PS, Schwitzgebel VM. 2012. Early metabolic defects in dexamethasone-exposed and undernourished intrauterine growth restricted rats. PLoS One 7: e50131.","DOI":"10.1371\/journal.pone.0050131"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Thorn SR, Rozance PJ, Brown LD, Hay WW Jr. 2011. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med 29: 225-236.","DOI":"10.1055\/s-0031-1275516"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Calkins K, Devaskar SU. 2011. Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care 41: 158-176.","DOI":"10.1016\/j.cppeds.2011.01.001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Barker DJ. 2005. The developmental origins of insulin resistance. Horm Res 64: 2-7.","DOI":"10.1159\/000089311"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Yuan Q, Chen L, Liu C, Xu K, Mao X, Liu C. 2011. Postnatal pancreatic islet beta cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation. PLoS One 6: e25167.","DOI":"10.1371\/journal.pone.0025167"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Setia S, Sridhar MG, Bhat V, Chaturvedula L, Vinayagamoorti R, John M. 2006. Insulin sensitivity and insulin secretion at birth in intrauterine growth retarded infants. Pathology 38: 236-238.","DOI":"10.1080\/00313020600696256"},{"key":"9","unstructured":"9) Zhang L, Shi X, Ni SN. 2010. Gene expression of Insulin\/FoxO1\/Pdx1\/MafA during pancreatic development in intrauterine growth retardation rats. Acta Univer Med Nanjing 30: 923-927."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Chen X, Rozance PJ, Hay WW Jr, Limesand SW. 2012. Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas. Exp Biol Med (Maywood) 237: 524-529.","DOI":"10.1258\/ebm.2012.011375"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G. 2016. Autophagy is a major regulator of beta cell insulin homeostasis. Diabetologia 59: 1480-1491.","DOI":"10.1007\/s00125-016-3868-9"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Bartolome A, Guillen C, Benito M. 2012. Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death. Autophagy 8: 1757-1768.","DOI":"10.4161\/auto.21994"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Fujitani Y, Ebato C, Uchida T, Kawamori R, Watada H. 2009. Beta-cell autophagy: A novel mechanism regulating beta-cell function and mass: Lessons from beta-cell-specific Atg7-deficient mice. Islets 1: 151-153.","DOI":"10.4161\/isl.1.2.9057"},{"key":"14","unstructured":"14) Fujitani Y, Watada H. 2012. Role of autophagy in pancreatic beta-cell homeostasis. Nihon Rinsho 70: 127-133."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Liu K, Zhao E, Ilyas G. 2015. Imparied macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy 11: 271-284.","DOI":"10.1080\/15548627.2015.1009787"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS. 2009. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem 284: 27664-27673.","DOI":"10.1074\/jbc.M109.041616"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC. 2010. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90: 1383-1435.","DOI":"10.1152\/physrev.00030.2009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Levine B, Klionsky DJ. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477.","DOI":"10.1016\/S1534-5807(04)00099-1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E. 2014. Maternal diet-induced microRNAs and mTOR underlie beta cell dysfunction in offspring. J Clin Invest 124: 4395-4410.","DOI":"10.1172\/JCI74237"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Wang C, Zhang R, Zhou L, He J, Huang Q, Siyal FA, Zhang L, Zhong X, Wang T. 2017. Intrauterine growth retardation promotes fetal intestinal autophagy in rats via the mechanistic target of rapamycin pathway. J Reprod Dev 63: 547-554.","DOI":"10.1262\/jrd.2017-050"},{"key":"21","unstructured":"21) Rashid HO, Yadav RK, Kim HR, Chae HJ. 2015. ER stress: Autophagy induction, inhibition and selection. Autophagy 11: 1956-1977."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Chu A, Thamotharan S, Ganguly A, Wadehra M, Pellegrini M, Devaskar SU. 2016. Gestational food restriction decreases placental interleukin-10 expression and markers of autophagy and endoplasmic reticulum stress in murine intrauterine growth restriction. Nutr Res 36: 1055-1067.","DOI":"10.1016\/j.nutres.2016.08.001"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Liu X, Qi Y, Gao H, Jiao Y, Gu H, Miao J, Yuan Z. 2013. Maternal protein restriction induces alterations in insulin signaling and ATP sensitive potassium channel protein in hypothalami of intrauterine growth restriction fetal rats. J Clin Biochem Nutr 52: 43-48.","DOI":"10.3164\/jcbn.12-28"},{"key":"24","unstructured":"24) Schlaudecker EP, Munoz FM, Bardaji A, Boghossian NS, Khalil A, Mousa H, Nesin M, Nisar MI, Pool V, Spiegel HML, Tapia MD, Kochhar S, Black S, Brighton Collaboration Small for Gestational Age Working Group. 2017. Small for gestational age: Case definition & guidelines for data collection, analysis, and presentation of maternal immunisation safety data. Vaccine 35: 6518-6528."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Dahri S, Snoeck A, Reusens-Billen B, Remacle C, Hoet JJ. 1991. Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40: 115-120.","DOI":"10.2337\/diab.40.2.S115"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Hung TH, Chen SF, Lo LM, Li MJ, Yeh YL, Hsieh TT. 2012. Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PLoS One 7: e40957.","DOI":"10.1371\/journal.pone.0040957"},{"key":"27","unstructured":"27) Liu Y, Zhang YJ, Fu DJ. 2011. Significance and expression of pancreatic and duodenal homeobox 1 in pancreatic islets of the newborn rats with intrauterine growth restriction. Chin J Birth Health Hered 19: 27-28."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kim SG, Buel GR, Blenis J. 2013. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells 35: 463-473.","DOI":"10.1007\/s10059-013-0138-2"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S. 2004. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24: 6710-6718.","DOI":"10.1128\/MCB.24.15.6710-6718.2004"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Laplante M, Sabatini DM. 2009. mTOR signaling at a glance. J Cell Sci 122: 3589-3594.","DOI":"10.1242\/jcs.051011"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tsch\u00f6p MH, Thomas G, Kozma SC. 2015. S6K1 controls pancreatic beta cell size independently of intrauterine growth restriction. J Clin Invest 125: 2736-2747.","DOI":"10.1172\/JCI77030"},{"key":"32","unstructured":"32) Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T. 2007. ER stress (PERK\/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 14: 230-239."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. 2000. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. 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