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Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin. J Oleo Sci 62: 181-186."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Daneman R, Prat A. 2015. The blood-brain barrier. Cold Spring Harb Perspect Biol 7: a020412.","DOI":"10.1101\/cshperspect.a020412"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Banks WA. 2016. From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov 15: 275-292.","DOI":"10.1038\/nrd.2015.21"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Manabe Y, Komatsu T, Seki S, Sugawara T. 2018. Dietary astaxanthin can accumulate in the brain of rats. Biosci Biotechnol Biochem 82: 1433-1436.","DOI":"10.1080\/09168451.2018.1459467"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Breitenbach J, Misawa N, Kajiwara S, Sandmann G. 1996. Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis. FEMS Microbiol Lett 140: 241-246.","DOI":"10.1111\/j.1574-6968.1996.tb08343.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Rhodes A. 2006. Dietary effects on carotenoid composition in the marine harpacticoid copepod Nitokra lacustris. J Plankton Res 29(Suppl 1): i73-i83.","DOI":"10.1093\/plankt\/fbl068"},{"key":"24","unstructured":"24) Nishino A, Ichihara T, Sugimoto K, Kuriki T, Yasui H, Maoka T. 2019. Predicting organ carotenoids levels from analysis of plasma could lead to errors: A study in cynomolgus monkeys. Nutr Res (New York, NY) 61: 95-101."},{"key":"25","unstructured":"25) Jewell C, O\u2019Brien NM. 1999. Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. Br J Nutr 81: 235-242."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Abadie-Guedes R, Guedes RC, Bezerra RS. 2012. The impairing effect of acute ethanol on spreading depression is antagonized by astaxanthin in rats of 2 young-adult ages. Alcoholism Clin Exp Res 36: 1563-1567.","DOI":"10.1111\/j.1530-0277.2012.01766.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Wen X, Huang A, Hu J, Zhong Z, Liu Y, Li Z, Pan X, Liu Z. 2015. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt\/GSK-3beta pathway. Neuroscience 303: 558-568.","DOI":"10.1016\/j.neuroscience.2015.07.034"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ji X, Peng D, Zhang Y, Zhang J, Wang Y, Gao Y, Lu N, Tang P. 2017. Astaxanthin improves cognitive performance in mice following mild traumatic brain injury. 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