{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:19:47Z","timestamp":1782375587322,"version":"3.54.5"},"reference-count":16,"publisher":"Center for Academic Publications Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci Vitaminol","JNSV","Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol","Journal of Nutritional Science and Vitaminology"],"published-print":{"date-parts":[[2022,12,31]]},"DOI":"10.3177\/jnsv.68.481","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T22:10:45Z","timestamp":1672438245000},"page":"481-487","source":"Crossref","is-referenced-by-count":4,"title":["Low Ascorbic Acid Intake Induces Inflammatory Changes in Intestine and Liver of ODS Rats"],"prefix":"10.3177","volume":"68","author":[{"given":"Noe","family":"KAWADE","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University"},{"name":"Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"SUZUKI","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misato","family":"KOBAYASHI","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University"},{"name":"Department of Nutritional Sciences, Nagoya University of Arts and Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamio","family":"OHNO","sequence":"additional","affiliation":[{"name":"Division of Experimental Animals, Graduate School of Medicine, Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"MURAI","sequence":"additional","affiliation":[{"name":"Division of Experimental Animals, Graduate School of Medicine, Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"HORIO","sequence":"additional","affiliation":[{"name":"Department of Life Studies and Environmental Science, Nagoya Women\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1759","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Kawade N, Murai A, Suzuki W, Tokuda Y, Kobayashi M, Horio F. 2019. Ascorbic acid deficiency increases hepatic expression of acute phase proteins through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats. J Nutr Biochem 70: 116-124.","DOI":"10.1016\/j.jnutbio.2019.04.012"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kawade N, Murai A, Suzuki W, Takeuchi K, Kondo M, Kobayashi M, Horio F. 2020. Ascorbic acid deficiency induces hepatic and intestinal expression of inflammation-related genes irrespective of the presence or absence of gut microbiota in ODS rats. J Nutr Biochem 86: 108485.","DOI":"10.1016\/j.jnutbio.2020.108485"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ikeda S, Horio F, Kakinuma A. 1998. Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats. J Nutr 128: 832-838.","DOI":"10.1093\/jn\/128.5.832"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Cheng HG, Alshaarawy O, Cantave MD, Anthony JC. 2016. Inverse association linking serum levels of potential antioxidant vitamins with C-reactive protein levels using a novel analytical approach. Br J Nutr 116: 1256-1264.","DOI":"10.1017\/S0007114516003159"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ford ES, Liu S, Mannino DM, Giles WH, Smith SJ. 2003. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr 57: 1157-1163.","DOI":"10.1038\/sj.ejcn.1601667"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kubota Y, Moriyama Y, Yamagishi K, Tanigawa T, Noda H, Yokota K, Harada M, Inagawa M, Oshima M, Sato S, Iso H. 2010. Serum vitamin C concentration and hs-CRP level in middle-aged Japanese men and women. Atherosclerosis 208: 496-500.","DOI":"10.1016\/j.atherosclerosis.2009.07.052"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Wannamethee SG, Lowe GD, Rumley A, Bruckdorfer KR, Whincup PH. 2006. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. Am J Clin Nutr 83: 567-574; quiz 726-727.","DOI":"10.1093\/ajcn.83.3.567"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Gao B, Wang H, Lafdil F, Feng D. 2012. STAT proteins\u2014key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver. J Hepatol 57: 430-441.","DOI":"10.1016\/j.jhep.2012.01.029"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Bode JG, Albrecht U, H\u00e4ussinger D, Heinrich PC, Schaper F. 2012. Hepatic acute phase proteins\u2014regulation by IL-6-and IL-1-type cytokines involving STAT3 and its crosstalk with NF-\u03baB-dependent signaling. Eur J Cell Biol 91: 496-505.","DOI":"10.1016\/j.ejcb.2011.09.008"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Fournier T, Medjoubi-N N, Porquet D. 2000. Alpha-1-acid glycoprotein. Biochim Biophys Acta 1482: 157-171.","DOI":"10.1016\/S0167-4838(00)00153-9"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tanaka T, Kishimoto T. 2012. Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases. Int J Biol Sci 8: 1227-1236.","DOI":"10.7150\/ijbs.4666"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yoshimura A, Suzuki M, Sakaguchi R, Hanada T, Yasukawa H. 2012. SOCS, inflammation, and autoimmunity. Front Immunol 3: 20.","DOI":"10.3389\/fimmu.2012.00020"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Horio F, Ozaki K, Yoshida A, Makino S, Hayashi Y. 1985. Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid. J Nutr 115: 1630-1640.","DOI":"10.1093\/jn\/115.12.1630"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Horio F, Yoshida A. 1982. Effects of some xenobiotics on ascorbic acid metabolism in rats. J Nutr 112: 416-425.","DOI":"10.1093\/jn\/112.3.416"},{"key":"15","unstructured":"15) Sugimoto T, Fukase M, Makino S, Hayashi Y, Fujita T. 1990. Role of ascorbic acid in osteoblastic function. In: Vitamin C and the Scurvy-Prone ODS Rat (Fujuta T, Fukase M, Konishi T, eds), p 65-73. Elsevier, Amsterdam, New York, Oxford."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Tonelli C, Chio IIC, Tuveson DA. 2018. Transcriptional regulation by Nrf2. Antioxid Redox Signal 29: 1727-1745.","DOI":"10.1089\/ars.2017.7342"}],"container-title":["Journal of Nutritional Science and Vitaminology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/68\/6\/68_481\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T04:48:06Z","timestamp":1715316486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/68\/6\/68_481\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,31]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.3177\/jnsv.68.481","relation":{},"ISSN":["0301-4800","1881-7742"],"issn-type":[{"value":"0301-4800","type":"print"},{"value":"1881-7742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,31]]}}}