{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:50:39Z","timestamp":1791510639445,"version":"4.3.4"},"reference-count":42,"publisher":"Center for Academic Publications Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci Vitaminol","JNSV","Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol","Journal of Nutritional Science and Vitaminology"],"published-print":{"date-parts":[[2024,8,31]]},"DOI":"10.3177\/jnsv.70.318","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T18:14:32Z","timestamp":1725041672000},"page":"318-327","source":"Crossref","is-referenced-by-count":5,"title":["Induction of the Lipid Droplet Formation Genes in Steatohepatitis Mice by Embryo\/Postnatal Nutrient Environment Is Associated with Histone Acetylation around the Genes"],"prefix":"10.3177","volume":"70","author":[{"given":"Shiori","family":"ISHIYAMA","sequence":"first","affiliation":[{"name":"Faculty of Life and Environmental Sciences, University of Yamanashi"},{"name":"Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"KIMURA","sequence":"additional","affiliation":[{"name":"Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"NAKAGAWA","sequence":"additional","affiliation":[{"name":"Kiwa Laboratory Animals Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"KISHIGAMI","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences, University of Yamanashi"},{"name":"Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi"},{"name":"Advanced Biotechnology Center, University of Yamanashi"},{"name":"Center for Advanced Assisted Reproductive Technologies, University of Yamanashi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"MOCHIZUKI","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences, University of Yamanashi"},{"name":"Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1759","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Estes C, Anstee QM, Arias-Loste MT, Bantel H, Bellentani S, Caballeria J, Colombo M, Craxi A, Crespo J, Day CP, Eguchi Y, Geier A, Kondili LA, Kroy DC, Lazarus JV, Loomba R, Manns MP, Marchesini G, Nakajima A, Negro F, Petta S, Ratziu V, Romero-Gomez M, Sanyal A, Schattenberg JM, Tacke F, Tanaka J, Trautwein C, Wei L, Zeuzem S, Razavi H. 2018. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030. J Hepatol 69: 896-904.","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T. 2012. Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol 47: 586-595.","DOI":"10.1007\/s00535-012-0533-z"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Itoh H, Kanayama N. 2018. Developmental origins of nonalcoholic fatty liver disease (NAFLD). Adv Exp Med Biol 1012: 29-39.","DOI":"10.1007\/978-981-10-5526-3_4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Itoh H, Muramatsu-Kato K, Ferdous UJ, Kohmura-Kobayashi Y, Kanayama N. 2017. Undernourishment in utero and hepatic steatosis in later life: A potential issue in Japanese people. Congenit Anom (Kyoto) 57: 178-183.","DOI":"10.1111\/cga.12200"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Nobili V, Marcellini M, Marchesini G, Vanni E, Manco M, Villani A, Bugianesi E. 2007. Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children. Diabetes Care 30: 2638-2640.","DOI":"10.2337\/dc07-0281"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Urmi JF, Itoh H, Muramatsu-Kato K, Kohmura-Kobayashi Y, Hariya N, Jain D, Tamura N, Uchida T, Suzuki K, Ogawa Y, Shiraki N, Mochizuki K, Kubota T, Kanayama N. 2019. Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis. Sci Rep 9: 17100.","DOI":"10.1038\/s41598-019-52943-7"},{"key":"7","unstructured":"7) Kishigami S, Mochizuki K, Wakayama T. 2020. The method for producing diabetic animal model and the diabetic animal model. Patent No. P2020-31551A (Japanese)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ishiyama S, Kimura M, Umihira N, Matsumoto S, Takahashi A, Nakagawa T, Wakayama T, Kishigami S, Mochizuki K. 2021. Consumption of barley ameliorates the diabetic steatohepatitis and reduces the high transforming growth factor beta expression in mice grown in alpha-minimum essential medium in vitro as embryos. Biochem Biophys Rep 27: 101029.","DOI":"10.1016\/j.bbrep.2021.101029"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Carr RM, Ahima RS. 2016. Pathophysiology of lipid droplet proteins in liver diseases. Exp Cell Res 340: 187-192.","DOI":"10.1016\/j.yexcr.2015.10.021"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Slayton M, Gupta A, Balakrishnan B, Puri V. 2019. CIDE proteins in human health and disease. Cells 8: 238.","DOI":"10.3390\/cells8030238"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Song YF, Hogstrand C, Ling SC, Chen GH, Luo Z. 2020. Creb-Pgc1alpha pathway modulates the interaction between lipid droplets and mitochondria and influences high fat diet-induced changes of lipid metabolism in the liver and isolated hepatocytes of yellow catfish. J Nutr Biochem 80: 108364.","DOI":"10.1016\/j.jnutbio.2020.108364"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Wang ND, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, Wilson DR, Darlington GJ. 1995. Impaired energy homeostasis in C\/EBP alpha knockout mice. Science 269: 1108-1112.","DOI":"10.1126\/science.7652557"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Muramatsu-Kato K, Itoh H, Kohmura-Kobayashi Y, Ferdous UJ, Tamura N, Yaguchi C, Uchida T, Suzuki K, Hashimoto K, Suganami T, Ogawa Y, Kanayama N. 2015. Undernourishment in utero primes hepatic steatosis in adult mice offspring on an obesogenic diet; Involvement of endoplasmic reticulum stress. Sci Rep 5: 16867.","DOI":"10.1038\/srep16867"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC. 2015. CHOP links endoplasmic reticulum stress to NF-kappaB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell 26: 2190-2204.","DOI":"10.1091\/mbc.E15-01-0036"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ron D, Habener JF. 1992. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453.","DOI":"10.1101\/gad.6.3.439"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Toriguchi K, Hatano E, Tanabe K, Takemoto K, Nakamura K, Koyama Y, Seo S, Taura K, Uemoto S. 2014. Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT\/enhancer-binding protein homologous protein deficiency. J Gastroenterol Hepatol 29: 1109-1118.","DOI":"10.1111\/jgh.12481"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Mochizuki K, Ishiyama S, Hariya N, Goda T. 2021. Regulation of carbohydrate-responsive metabolic genes by histone acetylation and the acetylated histone reader BRD4 in the gene body region. Front Mol Biosci 8: 682696.","DOI":"10.3389\/fmolb.2021.682696"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Klein FA, Atkinson RA, Potier N, Moras D, Cavarelli J. 2005. Biochemical and NMR mapping of the interface between CREB-binding protein and ligand binding domains of nuclear receptor: beyond the LXXLL motif. J Biol Chem 280: 5682-5692.","DOI":"10.1074\/jbc.M411697200"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kovacs KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR. 2003. CCAAT\/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. J Biol Chem 278: 36959-36965.","DOI":"10.1074\/jbc.M303147200"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408.","DOI":"10.1006\/meth.2001.1262"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Ishiyama S, Kimura M, Umihira N, Matsumoto S, Takahashi A, Nakagawa T, Wakayama T, Kishigami S, Mochizuki K. 2021. Mice derived from in vitro alphaMEM-cultured preimplantation embryos exhibit postprandial hyperglycemia and higher inflammatory gene expression in peripheral leukocytes. Biosci Biotechnol Biochem 85: 1215-1226.","DOI":"10.1093\/bbb\/zbab023"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Zhou L, Xu L, Ye J, Li D, Wang W, Li X, Wu L, Wang H, Guan F, Li P. 2012. Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology 56: 95-107.","DOI":"10.1002\/hep.25611"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Yamada A, Honma K, Mochizuki K, Goda T. 2016. BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver. Metabolism 65: 1478-1488.","DOI":"10.1016\/j.metabol.2016.07.001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, Goodman RH. 2004. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119: 1041-1054.","DOI":"10.1016\/S0092-8674(04)01159-6"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Mayr B, Montminy M. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599-609.","DOI":"10.1038\/35085068"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Vila-Brau A, De Sousa-Coelho AL, Goncalves JF, Haro D, Marrero PF. 2013. Fsp27\/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. J Lipid Res 54: 592-601.","DOI":"10.1194\/jlr.M028472"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Zhou XY, Shibusawa N, Naik K, Porras D, Temple K, Ou H, Kaihara K, Roe MW, Brady MJ, Wondisford FE. 2004. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med 10: 633-637.","DOI":"10.1038\/nm1050"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437: 1109-1111.","DOI":"10.1038\/nature03967"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) He L, Naik K, Meng S, Cao J, Sidhaye AR, Ma A, Radovick S, Wondisford FE. 2012. Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis. J Biol Chem 287: 32069-32077.","DOI":"10.1074\/jbc.M112.385864"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Osawa Y, Kojika E, Hayashi Y, Kimura M, Nishikawa K, Yoshio S, Doi H, Kanto T, Kimura K. 2018. Tumor necrosis factor-alpha-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice. Hepatol Commun 2: 407-420.","DOI":"10.1002\/hep4.1158"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kimura M, Nishikawa K, Osawa Y, Imamura J, Yamaji K, Harada K, Yatsuhashi H, Murata K, Miura K, Tanaka A, Kanto T, Kohara M, Kamisawa T, Kimura K. 2022. Inhibition of CBP\/beta-catenin signaling ameliorated fibrosis in cholestatic liver disease. Hepatol Commun 6: 2732-2747.","DOI":"10.1002\/hep4.2043"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Suzuki T, Muramatsu T, Morioka K, Goda T, Mochizuki K. 2015. ChREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model. Nutrition 31: 877-883.","DOI":"10.1016\/j.nut.2015.01.005"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kawamura M, Goda N, Hariya N, Kimura M, Ishiyama S, Kubota T, Mochizuki K. 2022. Medium-chain fatty acids enhance expression and histone acetylation of genes related to lipid metabolism in insulin-resistant adipocytes. Biochem Biophys Rep 29: 101196.","DOI":"10.1016\/j.bbrep.2021.101196"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Martin BJE, Brind\u2019Amour J, Kuzmin A, Jensen KN, Liu ZC, Lorincz M, Howe LJ. 2021. Transcription shapes genome-wide histone acetylation patterns. Nat Commun 12: 210.","DOI":"10.1038\/s41467-020-20543-z"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Feng Y, Cai L, Hong W, Zhang C, Tan N, Wang M, Wang C, Liu F, Wang X, Ma J, Gao C, Kumar M, Mo Y, Geng Q, Luo C, Lin Y, Chen H, Wang SY, Watson MJ, Jegga AG, Pedersen RA, Fu JD, Wang ZV, Fan GC, Sadayappan S, Wang Y, Pauklin S, Huang F, Huang W, Jiang L. 2022. Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy. Circulation 145: 1663-1683.","DOI":"10.1161\/CIRCULATIONAHA.121.055781"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Han YH, Kim HJ, Choi H, Lee S, Lee MO. 2020. RORalpha autoregulates its transcription via MLL4-associated enhancer remodeling in the liver. Life Sci 256: 118007.","DOI":"10.1016\/j.lfs.2020.118007"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Ooi JY, Tuano NK, Rafehi H, Gao XM, Ziemann M, Du XJ, El-Osta A. 2015. HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. Epigenetics 10: 418-430.","DOI":"10.1080\/15592294.2015.1024406"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O\u2019Shea JJ, Ozato K. 2014. BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Nat Struct Mol Biol 21: 1047-1057.","DOI":"10.1038\/nsmb.2912"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K. 2005. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell 19: 523-534.","DOI":"10.1016\/j.molcel.2005.06.027"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. 2017. The short isoform of BRD4 promotes HIV-1 latency by engaging repressive SWI\/SNF chromatin-remodeling complexes. Mol Cell 67: 1001-1012.e6.","DOI":"10.1016\/j.molcel.2017.07.025"}],"container-title":["Journal of Nutritional Science and Vitaminology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/70\/4\/70_318\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T23:43:53Z","timestamp":1725061433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnsv\/70\/4\/70_318\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,31]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.3177\/jnsv.70.318","relation":{},"ISSN":["0301-4800","1881-7742"],"issn-type":[{"value":"0301-4800","type":"print"},{"value":"1881-7742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,31]]}}}