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Severe vitamin D deficiency\u2014A possible cause of resistance to treatment in psychiatric pathology. Medicina 59: 2056.","DOI":"10.3390\/medicina59122056"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Al-Oanzi ZH, Alenazy FO, Alhassan HH, Alruwaili Y, Alessa AI, Alfarm NB, Alanazi MO, Alghofaili SI. 2023. The role of vitamin D in reducing the risk of metabolic disturbances that cause cardiovascular diseases. J Cardiovasc Dev Dis 10: 209.","DOI":"10.3390\/jcdd10050209"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) P\u00e1l \u00c9, Ungv\u00e1ri Z, Beny\u00f3 Z, V\u00e1rb\u00edr\u00f3 S. 2023. Role of vitamin D deficiency in the pathogenesis of cardiovascular and cerebrovascular diseases. Nutrients 15: 334.","DOI":"10.3390\/nu15020334"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Xi H, Li X, Zhou Y, Sun Y. 2024. The regulatory effect of the paraventricular nucleus on hypertension. Neuroendocrinology 114: 1-13.","DOI":"10.1159\/000533691"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Canavan M, O\u2019Donnell MJ. 2022. Hypertension and cognitive impairment: a review of mechanisms and key concepts. Front Neurol 13: 821135.","DOI":"10.3389\/fneur.2022.821135"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) G\u00e1ll Z, Sz\u00e9kely O. 2021. Role of vitamin D in cognitive dysfunction: new molecular concepts and discrepancies between animal and human findings. Nutrients 13: 3672.","DOI":"10.3390\/nu13113672"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Cui X, Eyles DW. 2022. Vitamin D and the central nervous system: Causative and preventative mechanisms in brain disorders. Nutrients 14: 4353.","DOI":"10.3390\/nu14204353"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D. 2001. 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MRI study of cerebral blood flow, vascular reactivity, and vascular coupling in systemic hypertension. Brain Res 1753: 147224.","DOI":"10.1016\/j.brainres.2020.147224"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Cipolla MJ, Liebeskind DS, Chan S-L. 2018. The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation. J Cereb Blood Flow Metab 38: 2129-2149.","DOI":"10.1177\/0271678X18800589"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Phillips AA, Matin N, Jia M, Squair JW, Monga A, Zheng MMZ, Sachdeva R, Yung A, Hocaloski S, Elliott S. 2018. Transient hypertension after spinal cord injury leads to cerebrovascular endothelial dysfunction and fibrosis. J Neurotrauma 35: 573-581.","DOI":"10.1089\/neu.2017.5188"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Rocha HN, Garcia VP, Batista GM, Silva GM, Mattos JD, Campos MO, N\u00f3brega AC, Fernandes IA, Rocha NG. 2018. Disturbed blood flow induces endothelial apoptosis without mobilizing repair mechanisms in hypertension. Life Sci 209: 103-110.","DOI":"10.1016\/j.lfs.2018.08.002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Zhang L, Papadopoulos P, Hamel E. 2013. Endothelial TRPV 4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer\u2019s disease. Br J Pharmacol 170: 661-670.","DOI":"10.1111\/bph.12315"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Biagioni F, Ferrucci M, Lazzeri G, Scioli M, Frati A, Puglisi-Allegra S, Fornai F. 2024. Damage to the locus coeruleus alters the expression of key proteins in limbic neurodegeneration. Int J Mol Sci 25: 3159.","DOI":"10.3390\/ijms25063159"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Paxinos G, Watson CR, Emson PC. 1980. AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods 3: 129-149.","DOI":"10.1016\/0165-0270(80)90021-7"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Han SY, Bouwer GT, Seymour AJ, Korpal AK, Schwenke DO, Brown CH. 2015. Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat. Eur J Neurosci 42: 2690-2698.","DOI":"10.1111\/ejn.13062"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ribeiro N, Panizza Hdo N, Santos KM, Ferreira-Neto HC, Antunes VR. 2015. Salt-induced sympathoexcitation involves vasopressin V1a receptor activation in the paraventricular nucleus of the hypothalamus. Am J Physiol Regul Integr Comp Physiol 309: R1369-R1379.","DOI":"10.1152\/ajpregu.00312.2015"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Savic B, Murphy D, Japundzic-Zigon N. 2022. The paraventricular nucleus of the hypothalamus in control of blood pressure and blood pressure variability. 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Nutr Metab Cardiovasc Dis 30: 114-122.","DOI":"10.1016\/j.numecd.2019.09.004"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Saponaro F, Marcocci C, Zucchi R. 2019. Vitamin D status and cardiovascular outcome. J Endocrinol Invest 42: 1285-1290.","DOI":"10.1007\/s40618-019-01057-y"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Hosseinzadeh F, Oskouei NJ, Ghavamzadeh S. 2020. An empirical study on the effect of short-term regular vitamin D3 supplement therapy on blood pressure and exercise tolerance in heart failure patients. Clin Nutr Res 9: 20-31.","DOI":"10.7762\/cnr.2020.9.1.20"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Roffe-Vazquez DN, Huerta-Delgado AS, Castillo EC, Villarreal-Calder\u00f3n JR, Gonzalez-Gil AM, Enriquez C, Garcia-Rivas G, Elizondo-Montemayor L. 2019. Correlation of vitamin D with inflammatory cytokines, atherosclerotic parameters, and lifestyle factors in the setting of heart failure: a 12-month follow-up study. Int J Molec Sci 20: 5811.","DOI":"10.3390\/ijms20225811"},{"key":"27","unstructured":"27) Saleem S, Siddiqui A, Iqbal Z. 2017. Vitamin D deficiency in patients of type 2 diabetes. Pakistan J Med Health Sci 11: 1324-1326."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Dou D, Yang B, Gan H, Xie D, Lei H, Ye N. 2019. Vitamin D supplementation for the improvement of vascular function in patients with chronic kidney disease: a meta-analysis of randomized controlled trials. Int Urol Nephrol 51: 851-858.","DOI":"10.1007\/s11255-019-02088-3"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Zhou C, Lu F, Cao K, Xu D, Goltzman D, Miao D. 2008. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1\u03b1-hydroxylase knockout mice. Kidney Int 74: 170-179.","DOI":"10.1038\/ki.2008.101"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Ren CZ, Yang YH, Sun JC, Wu ZT, Zhang RW, Shen D, Wang YK. 2016. 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Evidence for an impaired hormonal sympathetic reflex in hypertension and congestive heart failure. Endocr Metab Immune Disord Drug Targets 21: 1830-1844.","DOI":"10.2174\/1871530321666210319120308"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Littlejohn NK, Siel RB Jr, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR. 2013. Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. Am J Physiol Regul Integr Comp Physiol 304: R818-R828.","DOI":"10.1152\/ajpregu.00082.2013"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kagiyama S, Tsuchihashi T, Abe I, Matsumura K, Fujishima M. 1999. Antisense inhibition of angiotensinogen attenuates vasopressin release in the paraventricular hypothalamic nucleus of spontaneously hypertensive rats. Brain Res 829: 120-124.","DOI":"10.1016\/S0006-8993(99)01375-X"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Zhang F, Sun HJ, Xiong XQ, Chen Q, Li YH, Kang YM, Wang JJ, Gao XY, Zhu GQ. 2014. Apelin-13 and APJ in paraventricular nucleus contribute to hypertension via sympathetic activation and vasopressin release in spontaneously hypertensive rats. Acta Physiol 212: 17-27.","DOI":"10.1111\/apha.12342"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Aoyagi T, Koshimizu TA, Tanoue A. 2009. Vasopressin regulation of blood pressure and volume: findings from V1a receptor-deficient mice. Kidney Int 76: 1035-1039.","DOI":"10.1038\/ki.2009.319"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Jirikowski GF, Kauntzer UW, Dief AEE, Caldwell JD. 2009. Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus. Histochem Cell Biol 131: 365-370.","DOI":"10.1007\/s00418-008-0540-6"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Schaeffer S, Iadecola C. 2021. Revisiting the neurovascular unit. Nature Neurosci 24: 1198-1209.","DOI":"10.1038\/s41593-021-00904-7"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Muller M, van der Graaf Y, Visseren FL, Mali WPTM, Geerlings MI, SMART STUDY Group. 2012. Hypertension and longitudinal changes in cerebral blood flow: The SMART-MR study. Ann Neurol 71: 825-833.","DOI":"10.1002\/ana.23554"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Wiesmann M, Roelofs M, van der Lugt R, Heerschap A, Kiliaan AJ, Claassen JA. 2017. Angiotensin II, hypertension and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer\u2019s disease. 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