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Effects of brewer\u2019s yeast cell wall on constipation and defecation in experimentally constipated rats. Biosci Biotechnol Biochem 65(4): 774-780.","DOI":"10.1271\/bbb.65.774"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Lacey JM, Wilmore DW. 1990. Is glutamine a conditionally essential amino acid? Nutr Rev 48(8): 297-309.","DOI":"10.1111\/j.1753-4887.1990.tb02967.x"},{"key":"3","unstructured":"3) Nagano H. 2021. The diversity of <i>Saccharomyces cerevisiae<\/i> in cooked bread. J Cookery Sci Jpn 54(5): 209-214 (in Japanese)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Sender R, Fuchs S, Milo R. 2016. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 14(8): e1002533.","DOI":"10.1371\/journal.pbio.1002533"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Grider JR, Piland BE. 2007. The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. Am J Physiol Gastrointest Liver Physiol 292(1): G429-G437.","DOI":"10.1152\/ajpgi.00376.2006"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Pham NHT, Joglekar MV, Wong WKM, Nassif NT, Simpson AM, Hardikar AA. 2024. Short-chain fatty acids and insulin sensitivity: A systematic review and meta-analysis. Nutr Rev 82(2): 193-209.","DOI":"10.1093\/nutrit\/nuad042"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H. 2011. Bifidobacteria can protect from enteropathogenic infection through production of acetate. 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J Intest Microbiol 18: 107-115 (in Japanese)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yoshioka Y, Onishi K, Yasui K, Miyoshi N. 2024. PA YEAST SC-1, polyamine-rich <i>Saccharomyces cerevisiae<\/i>, induces muscle hypertrophy in C2C12 myotubes. J Nutr Sci Vitaminol 70(1): 53-60.","DOI":"10.3177\/jnsv.70.53"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Matsuoka H, Tochio T, Watanabe A, Funasaka K, Hirooka Y, Hartanto T, Togashi Y, Saito M, Nishimoto Y, Mizuguchi Y, Kumon M, Sakuragi C, Suda K, Hirose Y, Morita I. 2022. The effects of enteral nutrition on the intestinal environment in patients in a persistent vegetative state. Foods 11(4): 549.","DOI":"10.3390\/foods11040549"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Saji N, Murotani K, Hisada T, Kunihiro T, Tsuduki T, Sugimoto T, Kimura A, Niida S, Toba K, Sakurai T. 2020. Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan. Sci Rep 10(1): 8088.","DOI":"10.1038\/s41598-020-65196-6"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Park SK, Kim MS, Bae JW. 2013. <i>Blautia faecis<\/i> sp. nov., isolated from human faeces. Int J Syst Evol Micr 63(Pt_2): 599-603.","DOI":"10.1099\/ijs.0.036541-0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F. 2016. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165: 1332-1345.","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Cui Y, Zhang L, Wang X, Yi Y, Shan Y, Liu B, Zhou Y, L\u00fc X. 2022. Roles of intestinal Parabacteroides in human health and diseases. FEMS Microbiol Lett 369: fnac072.","DOI":"10.1093\/femsle\/fnac072"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Keitel L, Miebach K, Rummel L, Yordanov S, B\u00fcchs J. 2024. Process analysis of the anaerobe <i>Phocaeicola vulgatus<\/i> in a shake flasks and fermenter reveals pH and product inhibition. Ann Microbiol 74: 7.","DOI":"10.1186\/s13213-023-01745-4"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Macfarlane S, Macfarlane GT. 2003. Regulation of shortchain fatty acid production. Proc Nutr Sci 62: 67-72.","DOI":"10.1079\/PNS2002207"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Funabashi M, Grove TL, Wang M, Varma Y, McFadden ME, Brown LC, Guo C, Higginbottom S, Almo SC, Fischbach MA. 2020. A metabolic pathway for bile acid dehydroxylation by the gut microbiome. Nature 582: 566-570.","DOI":"10.1038\/s41586-020-2396-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yamamura R, Inoue KY, Nishino K, Yamasaki S. 2023. Intestinal and fecal pH in human health. Front Microbiomes 2.","DOI":"10.3389\/frmbi.2023.1192316"},{"key":"20","unstructured":"20) Sato T. 1996. Pan kobo. Korin Zensho, Tokyo, 1966. (in Japanese)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Fukuda I, Kodoi R. 2009. Amelioration of intestinal function by baker\u2019s yeast-derived \u03b2-glucan. J Brewing Soc Jpn 104(12): 939-943 (in Japanese).","DOI":"10.6013\/jbrewsocjapan.104.939"},{"key":"22","unstructured":"22) Tamakoshi M, Shinbori T, Imaruoka S, Ikemoto K. 2018. Polyamine-rich yeast and food\/drink composition containing same. WO2018\/168525 A1."},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Nakamura A, Kurihara S, Takahashi D, Ohashi W, Nakamura Y, Kimura S, Onuki M, Kume A, Sasazawa Y, Furusawa Y, Obata Y, Fukuda S, Saiki S, Matsumoto M, Hase K. 2021. Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon. 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