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The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus\u2013associated respiratory disease in early life.<\/jats:p>","DOI":"10.3181\/0705-bc-124","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T19:11:21Z","timestamp":1210619481000},"page":"1355-1359","source":"Crossref","is-referenced-by-count":12,"title":["A BRIEF COMMUNICATION"],"prefix":"10.3389","volume":"232","author":[{"given":"Carolina","family":"Scagnolari","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, and Pediatric Department, Sapienza University of Rome, Rome 00185, Italy; University Campus Bio-Medico, Rome 00155, Italy; and National Institute for Infectious Diseases, L. Spallanzani, Rome 00149, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Midulla","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, and Pediatric Department, Sapienza University of Rome, Rome 00185, Italy; University Campus Bio-Medico, Rome 00155, Italy; and National Institute for Infectious Diseases, L. Spallanzani, Rome 00149, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Trombetti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Virology Section, and Pediatric Department, Sapienza University of Rome, Rome 00185, Italy; University Campus Bio-Medico, Rome 00155, Italy; and National Institute for Infectious Diseases, L. 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