{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:42:22Z","timestamp":1777873342462,"version":"3.51.4"},"reference-count":34,"publisher":"Frontiers Media SA","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>MicroRNAs (miRNAs) are a recently discovered class of post-transcriptional regulators of gene expression with critical functions in health and disease. Their role in the pathogenesis of hypersplenism, however, is completely unknown. To determine whether miRNA expression is altered in splenic macrophages associated with hypersplenism due to portal hypertension in hepatitis-B-virus (HBV)-related cirrhosis, we analyzed the entire miRNAome in macrophages from normal and portal hypertensive spleen samples by microarray and Real-Time PCR. In this study, we identified 99 miRNA differences in expression in splenic macrophages associated with hypersplenism due to portal hypertension in HBV-related cirrhosis. Among the miRNAs identified in this study, hsa-miR-615\u20133p was significantly up-regulated in hypersplenism. Dynamic changes in miRNA expression occurred during the pathogenesis of portal hypertension-induced hypersplenism in HBV-related cirrhosis. The miRNAs then are novel regulatory RNAs in hypersplenism in patients with HBV-related cirrhosis.<\/jats:p>","DOI":"10.3181\/0711-rm-321","type":"journal-article","created":{"date-parts":[[2008,9,12]],"date-time":"2008-09-12T20:54:30Z","timestamp":1221252870000},"page":"1454-1461","source":"Crossref","is-referenced-by-count":15,"title":["MicroRNAome of Splenic Macrophages in Hypersplenism due to Portal Hypertension in Hepatitis B Virus-Related Cirrhosis"],"prefix":"10.3389","volume":"233","author":[{"given":"Zongfang","family":"Li","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi province, China 710004; Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, Shaanxi province, China 710006; Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612; and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi province, China 710004; Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, Shaanxi province, China 710006; Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612; and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi province, China 710004; Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, Shaanxi province, China 710006; Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612; and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi province, China 710004; Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, Shaanxi province, China 710006; Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612; and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Hu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi province, China 710004; Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, Shaanxi province, China 710006; Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612; and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi province, China 710004; Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, Shaanxi province, China 710006; Department of Human Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612; and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"bibr-R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"bibr-R2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510928103"},{"key":"bibr-R3","doi-asserted-by":"publisher","DOI":"10.1038\/nature02873"},{"key":"bibr-R4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076311"},{"key":"bibr-R5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"bibr-R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.028"},{"key":"bibr-R7","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-2-r27"},{"key":"bibr-R8","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0441"},{"key":"bibr-R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035"},{"key":"bibr-R10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01616.x"},{"key":"bibr-R11","unstructured":"Yan F, Li Z, Su Q, Ma S, Cao G, Zhang S. 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