{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:42:33Z","timestamp":1777873353421,"version":"3.51.4"},"reference-count":14,"publisher":"Frontiers Media SA","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2008,11]]},"abstract":"\n Background: Hepatic stellate cells (HSCs) are considered to be of vital importance in the pathogenesis of liver fibrosis. In vitro studies have demonstrated antiproliferative effects of 5-hydroxytryptamine\n 2<\/jats:sub>\n (5-HT\n 2<\/jats:sub>\n , serotonin) receptor antagonists upon HSCs. Terguride, recognized as a partial dopamine agonist, also has potent 5-HT\n 2<\/jats:sub>\n receptor antagonist qualities and has been shown to prevent serotonin-induced organ changes and fibrosis in rats. Aim: In the current study, the carbon tetrachloride (CCL\n 4<\/jats:sub>\n ) hepatic fibrosis rat model was used in combination with daily administration of terguride to evaluate potential preventive effects of a 5-HT\n 2<\/jats:sub>\n receptor antagonist upon liver fibrosis. Materials and Methods: Forty rats (Sprague-Dawley) were included in the study. Twelve animals received terguride in combination with CCL\n 4<\/jats:sub>\n and 12 animals were given only CCL\n 4<\/jats:sub>\n . The remaining 16 animals served as model controls. The extent of fibrosis was evaluated by liver weight, histologic analysis, biochemical analysis, and \u03b1-smooth muscle actin (\u03b1-SMA) immunohistochemistry. Results: There were no significant differences in liver weight, hydroxyproline content, serum alanine and aspartate transaminases, serum hyaluronic acid, or \u03b1-SMA immunostaining between rats treated with terguride in combination with CCL\n 4<\/jats:sub>\n and rats given only CCL\n 4<\/jats:sub>\n . All parameters, however, were significantly lower ( P < 0.01) in the model controls. Conclusion: Terguride, a potent 5-HT\n 2<\/jats:sub>\n antagonist, did not prevent the development of liver fibrosis in rats given CCL\n 4<\/jats:sub>\n .\n <\/jats:p>","DOI":"10.3181\/0804-rm-137","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T21:40:19Z","timestamp":1218750019000},"page":"1385-1388","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Terguride in Carbon Tetrachloride\u2013Induced Liver Fibrosis in Rat"],"prefix":"10.3389","volume":"233","author":[{"given":"\u00d8yvind","family":"Hauso","sequence":"first","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim, Norway; Department of Surgery, Yale University School of Medicine, New Haven, CT; Department of Pathology, Rikshospitalet HF, Oslo, Norway; Institute of Laboratory Medicine, Children\u2019s and Woman\u2019s Health, Faculty of Medicine, NTNU, Trondheim, Norway; and Department of Gastroenterology and Liver Diseases, St. Olavs Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn I.","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim, Norway; Department of Surgery, Yale University School of Medicine, New Haven, CT; Department of Pathology, Rikshospitalet HF, Oslo, Norway; Institute of Laboratory Medicine, Children\u2019s and Woman\u2019s Health, Faculty of Medicine, NTNU, Trondheim, Norway; and Department of Gastroenterology and Liver Diseases, St. Olavs Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivar S.","family":"Nordrum","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim, Norway; Department of Surgery, Yale University School of Medicine, New Haven, CT; Department of Pathology, Rikshospitalet HF, Oslo, Norway; Institute of Laboratory Medicine, Children\u2019s and Woman\u2019s Health, Faculty of Medicine, NTNU, Trondheim, Norway; and Department of Gastroenterology and Liver Diseases, St. Olavs Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge L.","family":"Waldum","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim, Norway; Department of Surgery, Yale University School of Medicine, New Haven, CT; Department of Pathology, Rikshospitalet HF, Oslo, Norway; Institute of Laboratory Medicine, Children\u2019s and Woman\u2019s Health, Faculty of Medicine, NTNU, Trondheim, Norway; and Department of Gastroenterology and Liver Diseases, St. Olavs Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"bibr-R1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01928.x"},{"key":"bibr-R2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.891"},{"key":"bibr-R3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"bibr-R4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200405"},{"key":"bibr-R5","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050767"},{"key":"bibr-R6","unstructured":"Li T, Weng SG, Leng XS, Peng JR, Wei YH, Mou DC, Wang WX. Effects of 5-hydroxytamine and its antagonists on hepatic stellate cells. Hepatobiliary Pancreat Dis Int 5:96\u2013100, 2006."},{"key":"bibr-R7","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.039875"},{"key":"bibr-R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.03.010"},{"key":"bibr-R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.02.009"},{"key":"bibr-R10","doi-asserted-by":"crossref","unstructured":"Constandinou C, Henderson N, Iredale JP. Modeling liver fibrosis in rodents. 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