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The patients have decreased n-3 polyunsaturated fatty acid (PUFA) proportions with decreased percentages of 18:3(n-3), 20:5(n-3) and 22:6(n-3) and an increased n-6\/n-3 PUFA ratio in liver and\/or white adipose tissue (WAT). The present study examined a new experimental model to study liver steatosis with possible future applications to NAFLD. Ten European polecats ( Mustela putorius), the wild form of the domestic ferret, were food-deprived for 5 days with 10 fed animals as controls. The food-deprived animals showed micro- and macrovesicular hepatic steatosis, decreased proportions of 20:5(n-3), 22:6(n-3) and total n-3 PUFA and increased n-6\/n-3 PUFA ratios in liver and WAT. At the same time, the product\/precursor ratios decreased in liver. The observed effects can be due to selective fatty acid mobilization preferring n-3 PUFA over n-6 PUFA, decreased \u03945 and \u03946 desaturase activities, oxidative stress, decreased arginine availability and activation of the endocannabinoid system. Hepatic lipidosis induced by food deprivation was manifested in the fatty acid composition of the polecat with similarities to human NAFLD despite the different principal etiologies.<\/jats:p>","DOI":"10.3181\/0806-rm-210","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T22:42:27Z","timestamp":1231972947000},"page":"278-286","source":"Crossref","is-referenced-by-count":23,"title":["Fatty Acid Composition and Development of Hepatic Lipidosis During Food Deprivation\u2014Mustelids as a Potential Animal Model for Liver Steatosis"],"prefix":"10.3389","volume":"234","author":[{"given":"Petteri","family":"Nieminen","sequence":"first","affiliation":[{"name":"University of Joensuu, Faculty of Biosciences, Joensuu FI-80101, Finland; University of Oulu, Faculty of Medicine, Institute of Biomedicine, Department of Anatomy and Cell Biology, Oulu FI-90014, Finland; Kuopio University Hospital, Department of Clinical Pathology, Kuopio FI-70211, Finland; and Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia B2N 5E3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mari","family":"Mustonen","sequence":"additional","affiliation":[{"name":"University of Joensuu, Faculty of Biosciences, Joensuu FI-80101, Finland; University of Oulu, Faculty of Medicine, Institute of Biomedicine, Department of Anatomy and Cell Biology, Oulu FI-90014, Finland; Kuopio University Hospital, Department of Clinical Pathology, Kuopio FI-70211, Finland; and Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia B2N 5E3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesa","family":"K\u00e4rj\u00e4","sequence":"additional","affiliation":[{"name":"University of Joensuu, Faculty of Biosciences, Joensuu FI-80101, Finland; University of Oulu, Faculty of Medicine, Institute of Biomedicine, Department of Anatomy and Cell Biology, Oulu FI-90014, Finland; Kuopio University Hospital, Department of Clinical Pathology, Kuopio FI-70211, Finland; and Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia B2N 5E3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Asikainen","sequence":"additional","affiliation":[{"name":"University of Joensuu, Faculty of Biosciences, Joensuu FI-80101, Finland; University of Oulu, Faculty of Medicine, Institute of Biomedicine, Department of Anatomy and Cell Biology, Oulu FI-90014, Finland; Kuopio University Hospital, Department of Clinical Pathology, Kuopio FI-70211, Finland; and Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia B2N 5E3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsti","family":"Rouvinen-Watt","sequence":"additional","affiliation":[{"name":"University of Joensuu, Faculty of Biosciences, Joensuu FI-80101, Finland; University of Oulu, Faculty of Medicine, Institute of Biomedicine, Department of Anatomy and Cell Biology, Oulu FI-90014, Finland; Kuopio University Hospital, Department of Clinical Pathology, Kuopio FI-70211, Finland; and Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia B2N 5E3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"bibr-R1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.045232"},{"key":"bibr-R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.09.008"},{"key":"bibr-R3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802734"},{"key":"bibr-R4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20466"},{"key":"bibr-R5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20818"},{"key":"bibr-R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.030"},{"key":"bibr-R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.06.013"},{"key":"bibr-R8","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030326"},{"key":"bibr-R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.09.009"},{"key":"bibr-R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.027"},{"key":"bibr-R11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02885.x"},{"key":"bibr-R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.033"},{"key":"bibr-R13","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-004-0452-2"},{"key":"bibr-R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2004.12.004"},{"key":"bibr-R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2006.03.008"},{"key":"bibr-R16","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(96)03351-3"},{"key":"bibr-R17","unstructured":"Rouvinen-Watt K. 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