{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:20:24Z","timestamp":1789993224723,"version":"4.0.1"},"reference-count":41,"publisher":"Frontiers Media SA","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Biol Med (Maywood)"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>Previous studies have shown that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a unique role in many physiological stress processes. The present study investigated the role of Nrf2 in the regulation of traumatic brain injury (TBI)-induced acute lung injury (ALI). Wild-type Nrf2 (+\/+) and Nrf2 (\u2212\/\u2212)-deficient mice were subjected to a moderately severe weight-drop impact head injury. Pulmonary capillary permeability (PCP), wet\/dry weight ratio, apoptosis, inflammatory cytokines and antioxidant\/detoxifying enzymes were measured at 24 h after TBI. Mice lacking Nrf2 were found to be more susceptible to TBI-induced ALI, as characterized by the higher increase in PCP, wet\/dry weight ratio and alveolar cells apoptosis after TBI. This exacerbation of lung injury in Nrf2-deficient mice was associated with increased pulmonary mRNA and protein expression of inflammatory cytokines such as tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2) and interleukin-6 (IL-6); and with decreased pulmonary mRNA expression and enzymatic activities of antioxidant and detoxifying enzymes including NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase \u03b11 (GST-\u03b11)\u2014as compared with their wild-type Nrf2 (+\/+) counterparts after TBI. The results of the present study suggest that Nrf2 reduces TBI-induced acute lung injury, possibly by decreasing pulmonary inflammation and inducing antioxidant and detoxifying enzymes.<\/jats:p>","DOI":"10.3181\/0807-rm-232","type":"journal-article","created":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T14:33:56Z","timestamp":1233066836000},"page":"181-189","source":"Crossref","is-referenced-by-count":26,"title":["Genetic Ablation of Nrf2 Enhances Susceptibility to Acute Lung Injury After Traumatic Brain Injury in Mice"],"prefix":"10.3389","volume":"234","author":[{"given":"Wei","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, People\u2019s Republic of China; Department of Preventive Dentistry, Affiliated Stomatology Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, People\u2019s Republic of China; and Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"bibr-R1","unstructured":"Dettbarn CL, Davidson LJ. 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