{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:24:00Z","timestamp":1770236640758,"version":"3.49.0"},"reference-count":93,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p> Microalgae and cyanobacteria are rich sources of many valuable compounds, including important bioactive and biotechnologically relevant chemicals. Their enormous biodiversity, and the consequent variability in the respective biochemical composition, make microalgae cultivations a promising resource for many novel chemically and biologically active molecules and compounds of high commercial value such as lipids and dyes. The nature of the chemicals produced can be manipulated by changing the cultivation media and conditions. Algae are extremely versatile because they can be adapted to a variety of cell culture conditions. They do not require arable land, can be cultivated on saline water and wastewaters, and require much less water than plants. They possess an extremely high growth rate making these microorganisms very attractive for use in biofuel production \u2013 some species of algae can achieve around 100 times more oil than oil seeds. In addition, microalgae and cyanobacteria can accumulate various biotoxins and can contribute to mitigate greenhouse gases since they produce biomass through carbon dioxide fixation. In this review, we provide an overview of the application of microalgae in the production of bioactive and other chemicals. <\/jats:p>","DOI":"10.3184\/003685015x14298590596266","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T00:26:46Z","timestamp":1432945606000},"page":"145-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Cyanobacteria and Microalgae: A Renewable Source of Bioactive Compounds and Other Chemicals"],"prefix":"10.1177","volume":"98","author":[{"given":"Telma","family":"Encarna\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal."}]},{"given":"Alberto A.C.C.","family":"Pais","sequence":"additional","affiliation":[{"name":"Department of Chemistry of the University of Coimbra."}]},{"given":"Maria G.","family":"Campos","sequence":"additional","affiliation":[{"name":"Coimbra University."}]},{"given":"Hugh D.","family":"Burrows","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Coimbra, Portugal."}]}],"member":"179","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"bibr1-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.2216\/i0031-8884-35-4-308.1"},{"key":"bibr2-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1093\/plankt\/19.11.1637"},{"key":"bibr3-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0802-54"},{"key":"bibr4-003685015X14298590596266","volume-title":"Handbook of microalgal cultures, biotechnology and applied Phycology.","author":"Richmond A.","year":"2004"},{"key":"bibr5-003685015X14298590596266","volume":"2","author":"Encarna\u00e7\u00e3o T.","year":"2012","journal-title":"J. Agric. Sci. Technol."},{"key":"bibr6-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2007.02.001"},{"key":"bibr7-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1038\/35059210"},{"key":"bibr8-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s11120-010-9593-1"},{"key":"bibr9-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2007.10.010"},{"key":"bibr10-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69371-0_6"},{"key":"bibr11-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0276"},{"key":"bibr12-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/jf0010376"},{"key":"bibr13-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6390-0"},{"key":"bibr14-003685015X14298590596266","unstructured":"BeckerE.W. (1994) In: BaddileyJ.  (eds), Microalgae: biotechnology and microbiology, pp. 178. Cambridge University Press."},{"key":"bibr15-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-007-9189-0"},{"key":"bibr16-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.cep.2007.04.013"},{"key":"bibr17-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2008.08.009"},{"key":"bibr18-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.06.120"},{"key":"bibr19-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.02.088"},{"key":"bibr20-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1023\/B:BILE.0000045626.38354.1a"},{"key":"bibr21-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(00)00101-1"},{"key":"bibr22-003685015X14298590596266","volume-title":"Biology of microorganisms","author":"Madigan M.T.","year":"2012"},{"key":"bibr23-003685015X14298590596266","unstructured":"FalkowskiP.G., and RavenJ.A. (1997) Aquatic photosynthesis, p. 375. Blackwell Scientific Publishers, Oxford."},{"key":"bibr24-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1080\/07388550500248498"},{"key":"bibr25-003685015X14298590596266","unstructured":"Florida Fish and Wildlife Conservation Commission (FWC) http:\/\/www.flickr.com\/photos\/myfwc\/5884548128\/."},{"key":"bibr26-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)00931-0"},{"key":"bibr27-003685015X14298590596266","volume-title":"Toxicology: the basic science of poisons","author":"Casarett","year":"2008"},{"key":"bibr28-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/np0605844"},{"key":"bibr29-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.3390\/md8072185"},{"key":"bibr30-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/jf060799j"},{"key":"bibr31-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(99)00833-9"},{"key":"bibr32-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1227"},{"key":"bibr33-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959626"},{"key":"bibr34-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/0141-8130(95)98157-T"},{"key":"bibr35-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008065226194"},{"key":"bibr36-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/BF00003544"},{"key":"bibr37-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961501"},{"key":"bibr38-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.09.004"},{"key":"bibr39-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-005-9011-9"},{"key":"bibr40-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/tx034037j"},{"key":"bibr41-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-3484-9"},{"key":"bibr42-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.12.006"},{"key":"bibr43-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-003-0002-z"},{"key":"bibr44-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7799(00)01433-5"},{"key":"bibr45-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959653"},{"key":"bibr46-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/ja010453j"},{"key":"bibr47-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/ol017275j"},{"key":"bibr48-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/ol9020546"},{"key":"bibr49-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.128546"},{"key":"bibr50-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/np900546u"},{"key":"bibr51-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10499-006-9060-3"},{"key":"bibr52-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.096016"},{"key":"bibr53-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2005.08.005"},{"key":"bibr54-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/np980444x"},{"key":"bibr55-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.07.014"},{"key":"bibr56-003685015X14298590596266","first-page":"69","volume":"1","author":"Pankaj P.P.","year":"2010","journal-title":"The Bioscan"},{"key":"bibr57-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.173278"},{"key":"bibr58-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961501"},{"key":"bibr59-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961500"},{"key":"bibr60-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10363"},{"key":"bibr61-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900192"},{"key":"bibr62-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1021\/np010049y"},{"key":"bibr63-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(03)00300-5"},{"key":"bibr64-003685015X14298590596266","unstructured":"http:\/\/www.who.int\/bulletin\/volumes\/89\/2\/11-030211\/en\/ (last accessed August 2013)."},{"key":"bibr65-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"bibr66-003685015X14298590596266","unstructured":"http:\/\/www.emea.europa.eu\/pdfs\/human\/antimicrobial_resistance\/EMEA-576176-2009.pdf (last accessed July 2013)."},{"key":"bibr67-003685015X14298590596266","first-page":"763","volume":"1","author":"Hannon M.","year":"2010","journal-title":"Future Sci."},{"key":"bibr68-003685015X14298590596266","volume-title":"Chemicals from microalgae.","author":"Cohen Z.","year":"1999"},{"key":"bibr69-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-010-2470-1"},{"key":"bibr70-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(02)00758-X"},{"key":"bibr71-003685015X14298590596266","first-page":"2313","volume":"105","author":"Wrasidlo W.","year":"2007","journal-title":"Appl. Biol. Sci."},{"key":"bibr72-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.3390\/md9101840"},{"key":"bibr73-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-5-7"},{"key":"bibr74-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(97)00102-5"},{"key":"bibr75-003685015X14298590596266","unstructured":"http:\/\/www.who.int\/water_sanitation_health\/resourcesquality\/toxcyanchap3.pdf (last accessed July 2013)."},{"key":"bibr76-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212200-00033"},{"key":"bibr77-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01174-3"},{"key":"bibr78-003685015X14298590596266","first-page":"1","volume":"23","author":"Faber S.","year":"2012","journal-title":"J. Young Investigators"},{"key":"bibr79-003685015X14298590596266","first-page":"16331","volume":"99","author":"Aspinall-O'Dea M.","year":"2002","journal-title":"Plant Biol."},{"key":"bibr80-003685015X14298590596266","volume-title":"Photobiology of higher plants.","author":"McDonald M.","year":"2003"},{"key":"bibr81-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.02.020"},{"key":"bibr82-003685015X14298590596266","first-page":"165","volume":"13","author":"Eonseon J.","year":"2003","journal-title":"J. Microbiol. Biotechnol."},{"key":"bibr83-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00367-3"},{"key":"bibr84-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.343s"},{"key":"bibr85-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-013-9983-9"},{"key":"bibr86-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.3184\/003685009X440281"},{"key":"bibr87-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2009.06.004"},{"key":"bibr88-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2008.06.039"},{"key":"bibr89-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10811-010-9626-3"},{"key":"bibr90-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-008-0495-6"},{"key":"bibr91-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/BF02858416"},{"key":"bibr92-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s00374-010-0491-7"},{"key":"bibr93-003685015X14298590596266","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-005-7024-9"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3184\/003685015X14298590596266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3184\/003685015X14298590596266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T21:44:47Z","timestamp":1741643087000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3184\/003685015X14298590596266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.3184\/003685015X14298590596266"],"URL":"https:\/\/doi.org\/10.3184\/003685015x14298590596266","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}