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A selection of the compounds and of other estra-1,3,5(10)-trien-3-ol 17\u03b2-yl hydroxycinnamides was screened against 60 human cancer cell lines, derived from nine neoplastic diseases. From the overall results of the screening, it could be inferred that dihydroxycinnamide derived estradiol conjugates exhibit a better cytotoxic profile when compared with hydroxymethoxycinnamide derived estradiol conjugates.<\/jats:p>","DOI":"10.3184\/174751912x13419346932954","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T17:22:55Z","timestamp":1347470575000},"page":"549-554","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of Estradiol-Cinnamide Conjugates"],"prefix":"10.1177","volume":"36","author":[{"given":"Goreti Ribeiro","family":"Morais","sequence":"first","affiliation":[{"name":"Instituto Superior T\u00e9cnico\/Instituto Tecnol\u00f3gico e Nuclear, Estrada Nacional 10, Sacavem, Portugal"}]},{"given":"Thies","family":"Thiemann","sequence":"additional","affiliation":[{"name":"Institute of Materials Chemistry and Engineering, Kyushu University, Kasuga 2686-953, Fukuoka 816-8580, Japan"},{"name":"Present address: Faculty of Science, United Arab Emirates University, PO Box 17551, Al Ain, UAE"}]}],"member":"179","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"bibr1-174751912X13419346932954","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<1033::AID-JSFA595>3.0.CO;2-T"},{"key":"bibr2-174751912X13419346932954","doi-asserted-by":"publisher","DOI":"10.1080\/10715760290029182"},{"key":"bibr3-174751912X13419346932954","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03948-V"},{"key":"bibr4-174751912X13419346932954","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01339-1"},{"key":"bibr5-174751912X13419346932954","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)82453-7"},{"key":"bibr6-174751912X13419346932954","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.11.2367"},{"key":"bibr7-174751912X13419346932954","first-page":"223","volume":"395","author":"Birt D.F.","year":"1996","journal-title":"Prog. 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