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Thermal dynamics and binding affinity were modeled by the exhaustive docking method sites. Blocker molecules with higher affinity for the blocking sites were proposed. The most probable mutations of amino acids of protein M2 and E channels are considered, the effectiveness of channel blocking are analyzed and optimal structures of blocker molecules are proposed.<\/jats:p>","DOI":"10.31857\/s0026898424040125","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T12:01:46Z","timestamp":1735560106000},"source":"Crossref","is-referenced-by-count":0,"title":["Molecular Ion Channel Blockers of Influenza A and SARS-CoV-2 Viruses"],"prefix":"10.31857","volume":"58","author":[{"given":"Yu. 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