{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:46:16Z","timestamp":1793033176014,"version":"4.5.0"},"reference-count":33,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.3201\/eid0904.020395","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T14:17:55Z","timestamp":1376403475000},"page":"461-468","source":"Crossref","is-referenced-by-count":242,"title":["Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes"],"prefix":"10.3201","volume":"9","author":[{"given":"Mary Jane","family":"Cardosa","sequence":"first","affiliation":[{"name":"Universiti Malaysia Sarawak, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perera","sequence":"additional","affiliation":[{"name":"Universiti Malaysia Sarawak, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doosung","family":"Cheon","sequence":"additional","affiliation":[{"name":"National Institute of Health, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Ming","family":"Chan","sequence":"additional","affiliation":[{"name":"Universiti Malaysia Sarawak, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwai Peng","family":"Chan","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haewol","family":"Cho","sequence":"additional","affiliation":[{"name":"National Institute of Health, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McMinn","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid0904.020395-201308131017-R1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system.","volume":"129","author":"Schmidt","year":"1974","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid0904.020395-201308131017-R2","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/adc.55.8.583","article-title":"Outbreaks of hand, foot, and mouth disease by enterovirus 71: high incidence of complication disorders of central nervous system.","volume":"55","author":"Ishimaru","year":"1980","journal-title":"Arch Dis Child"},{"key":"key-10.3201\/eid0904.020395-201308131017-R3","doi-asserted-by":"crossref","first-page":"S387","DOI":"10.1093\/clinids\/6.Supplement_2.S387","article-title":"Enterovirus type 71 infections: a varied clinical pattern sometimes mimicking paralytic poliomyelitis.","volume":"6","author":"Melnick","year":"1984","journal-title":"Rev Infect Dis"},{"key":"key-10.3201\/eid0904.020395-201308131017-R4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/infdis\/169.4.905","article-title":"Enterovirus 71 infections and neurologic disease\u2014United States, 1977\u20131991.","volume":"169","author":"Alexander","year":"1994","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid0904.020395-201308131017-R5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/00006454-198807000-00007","article-title":"Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement.","volume":"7","author":"Gilbert","year":"1988","journal-title":"Pediatr Infect Dis J"},{"key":"key-10.3201\/eid0904.020395-201308131017-R6","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/00006454-198702000-00013","article-title":"Monoplegia caused by enterovirus 71: an outbreak in Hong Kong.","volume":"6","author":"Samuda","year":"1987","journal-title":"Pediatr Infect Dis J"},{"key":"key-10.3201\/eid0904.020395-201308131017-R7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF01317504","article-title":"Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria.","volume":"60","author":"Chumakov","year":"1979","journal-title":"Arch Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/BF01314873","article-title":"Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978.","volume":"71","author":"Nagy","year":"1982","journal-title":"Arch Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R9","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group.","volume":"31","author":"Chan","year":"2000","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid0904.020395-201308131017-R10","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.","volume":"341","author":"Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid0904.020395-201308131017-R11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JCM.40.1.10-15.2002","article-title":"Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000.","volume":"40","author":"Wang","year":"2002","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R12","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/S0140-6736(05)60789-1","article-title":"Neurogenic pulmonary oedema and enterovirus 71 encephalomyelitis.","volume":"352","author":"Lum","year":"1998","journal-title":"Lancet"},{"key":"key-10.3201\/eid0904.020395-201308131017-R13","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0140-6736(98)24031-1","article-title":"Fulminant neurogenic pulmonary oedema with hand, foot and mouth disease.","volume":"352","author":"Chang","year":"1998","journal-title":"Lancet"},{"key":"key-10.3201\/eid0904.020395-201308131017-R14","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0140-6736(98)11032-2","article-title":"Isolation of subgenus B adenovirus during a fatal outbreak of enterovirus 71-associated hand, foot, and mouth disease in Sibu, Sarawak.","volume":"354","author":"Cardosa","year":"1999","journal-title":"Lancet"},{"key":"key-10.3201\/eid0904.020395-201308131017-R15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7883\/yoken.52.12","article-title":"Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997\u20131998.","volume":"52","author":"Shimizu","year":"1999","journal-title":"Jpn J Infect Dis"},{"key":"key-10.3201\/eid0904.020395-201308131017-R16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1386-6532(00)00079-2","article-title":"An outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysis.","volume":"17","author":"Wang","year":"2000","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0168-1702(00)00162-3","article-title":"Genetic analysis of enterovirus 71 isolated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998.","volume":"68","author":"Shih","year":"2000","journal-title":"Virus Res"},{"key":"key-10.3201\/eid0904.020395-201308131017-R18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0166-0934(00)00185-3","article-title":"nucleotide, amino acid and phylogenetic analyses of enterovirus type 71 strains from Asia.","volume":"88","author":"Singh","year":"2000","journal-title":"J Virol Methods"},{"key":"key-10.3201\/eid0904.020395-201308131017-R19","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s007050170164","article-title":"Molecular epidemiology of enterovirus 71 in Taiwan.","volume":"146","author":"Chu","year":"2001","journal-title":"Arch Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-1702(99)00019-2","article-title":"Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia.","volume":"61","author":"AbuBakar","year":"1999","journal-title":"Virus Res"},{"key":"key-10.3201\/eid0904.020395-201308131017-R21","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998.","volume":"73","author":"Brown","year":"1999","journal-title":"J Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R22","doi-asserted-by":"publisher","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia.","volume":"75","author":"McMinn","year":"2001","journal-title":"J Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3201\/eid0901.020112","article-title":"Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore.","volume":"9","author":"Chan","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid0904.020395-201308131017-R24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1386-6532(00)00065-2","article-title":"Serotype-specific identification of enterovirus 71 by PCR.","volume":"16","author":"Brown","year":"2000","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R25","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"key-10.3201\/eid0904.020395-201308131017-R26","first-page":"164","article-title":"PHYLIP\u2014phylogeny inference package (version 3.5).","volume":"5","author":"Felsenstein","year":"1989","journal-title":"Cladistics"},{"key":"key-10.3201\/eid0904.020395-201308131017-R27","first-page":"357","article-title":"TreeView: an application to display phylogenetic trees on personal computers.","volume":"12","author":"Page","year":"1996","journal-title":"Comput Appl Biosci"},{"key":"key-10.3201\/eid0904.020395-201308131017-R28","unstructured":"Genetics Computer Group. Program manual for the Wisconsin GCG package. 8.0 1994 ed. Madison (WI): Genetics Computer Group; 1994"},{"key":"key-10.3201\/eid0904.020395-201308131017-R29","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1006\/viro.1994.1423","article-title":"Molecular analysis of coxsackie virus A16 reveals a new genetic group of enteroviruses.","volume":"202","author":"Poyry","year":"1994","journal-title":"Virology"},{"key":"key-10.3201\/eid0904.020395-201308131017-R30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0168-1702(95)00087-9","article-title":"Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus.","volume":"39","author":"Brown","year":"1995","journal-title":"Virus Res"},{"key":"key-10.3201\/eid0904.020395-201308131017-R31","doi-asserted-by":"crossref","unstructured":"Stanway G, Hovi T, Knowles NJ, Hyypia T. Molecular and biological basis of Picornavirus taxonomy. In: Semler BL, Wimmer E, editors. Molecular biology of picornaviruses. Washington: ASM Press; 2002. p. 17\u201324.","DOI":"10.1128\/9781555817916.ch2"},{"key":"key-10.3201\/eid0904.020395-201308131017-R32","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","article-title":"Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification.","volume":"73","author":"Oberste","year":"1999","journal-title":"J Virol"},{"key":"key-10.3201\/eid0904.020395-201308131017-R33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/317145a0","article-title":"Structure of a human common cold virus and functional relationship to other picornaviruses.","volume":"317","author":"Rossman","year":"1985","journal-title":"Nature"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/9\/4\/02-0395_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T02:43:58Z","timestamp":1732589038000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/9\/4\/02-0395_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"URL":"https:\/\/doi.org\/10.3201\/eid0904.020395","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}