{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:30:53Z","timestamp":1792647053616,"version":"4.5.0"},"reference-count":37,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.3201\/eid1101.040303","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T15:04:08Z","timestamp":1330614248000},"page":"36-41","source":"Crossref","is-referenced-by-count":78,"title":["Hypersensitivity to Ticks and Lyme Disease Risk"],"prefix":"10.3201","volume":"11","author":[{"given":"Georgine","family":"Burke","sequence":"first","affiliation":[{"name":"Connecticut Children's Medical Center, Hartford, Connecticut, USA;"},{"name":"University of Connecticut School of Medicine, Hartford, Connecticut, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Wikel","sequence":"additional","affiliation":[{"name":"University of Connecticut School of Medicine, Hartford, Connecticut, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Spielman","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, Massachusetts, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam R.","family":"Telford","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, Massachusetts, USA;"},{"name":"Tufts University School of Veterinary Medicine, North Grafton, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"McKay","sequence":"additional","affiliation":[{"name":"Connecticut Children's Medical Center, Hartford, Connecticut, USA;"},{"name":"University of Connecticut School of Medicine, Hartford, Connecticut, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Krause","sequence":"additional","affiliation":[{"name":"Connecticut Children's Medical Center, Hartford, Connecticut, USA;"},{"name":"University of Connecticut School of Medicine, Hartford, Connecticut, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Tick-borne Infection Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid1101.040303-202410292318-R1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1749-6632.1988.tb31905.x","article-title":"A survey of tick bites acquired in a Lyme disease endemic area in southern New York State.","volume":"539","author":"Falco","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"key-10.3201\/eid1101.040303-202410292318-R2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/oxfordjournals.aje.a009568","article-title":"Estimation of the incidence of Lyme disease.","volume":"148","author":"Campbell","year":"1991","journal-title":"Am J Epidemiol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4269\/ajtmh.2003.68.431","article-title":"Increasing health burden of human babesiosis in endemic sites.","volume":"68","author":"Krause","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid1101.040303-202410292318-R4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev.en.30.010185.002255","article-title":"Ecology of Ixodes dammini-borne human babesiosis and Lyme disease.","volume":"30","author":"Spielman","year":"1985","journal-title":"Annu Rev Entomol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/jcm.24.3.446-447.1986","article-title":"Concurrent Borrelia burgdorferi and Babesia microti infection in nymphal Ixodes dammini.","volume":"24","author":"Piesman","year":"1986","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R6","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1128\/JCM.36.5.1240-1244.1998","article-title":"Temporal correlations between tick abundance and prevalence of ticks infected with Borrelia burgdorferi and increasing incidence of Lyme disease.","volume":"36","author":"Stafford","year":"1998","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R7","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1080\/0036554021000026955","article-title":"Risk of acquiring tick bites in south-eastern Sweden.","volume":"34","author":"Stjernberg","year":"2002","journal-title":"Scand J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R8","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1056\/NEJMra021397","article-title":"How can we prevent Lyme disease?","volume":"348","author":"Hayes","year":"2003","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid1101.040303-202410292318-R9","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.4049\/jimmunol.171.5.2660","article-title":"Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans.","volume":"171","author":"Salazar","year":"2003","journal-title":"J Immunol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.en.41.010196.000245","article-title":"Host immunity to ticks.","volume":"41","author":"Wikel","year":"1996","journal-title":"Annu Rev Entomol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev.ento.48.060402.102812","article-title":"Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives.","volume":"48","author":"Ribeiro","year":"2003","journal-title":"Annu Rev Entomol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1365-2222.1989.tb02384.x","article-title":"Allergic reactions to the Australian paralysis tick, Ixodes holocyclus: diagnostic evaluation by skin test and radioimmuneassay.","volume":"19","author":"Gauci","year":"1989","journal-title":"Clin Exp Allergy"},{"key":"key-10.3201\/eid1101.040303-202410292318-R13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S1081-1206(10)63082-7","article-title":"Unusual manifestations of hypersensitivity after a tick bite: report of two cases.","volume":"79","author":"Beaudouin","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R14","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/infdis\/169.3.668","article-title":"Target imbalance: disparity of Borrelia burgdorferi genetic material in synovial fluid from Lyme arthritis patients.","volume":"169","author":"Persing","year":"1994","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R15","unstructured":"Rys PN. PCR detection of\n                      Borrelia burgdorferi\n                      . In: Persing DH, Smith TF, Tenover F, White JT, editors. Diagnostic molecular microbiology: principles and applications. Washington: American Society for Microbiology; 1993. p. 203\u201310."},{"key":"key-10.3201\/eid1101.040303-202410292318-R16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4269\/ajtmh.2001.65.563","article-title":"Evaluation of two-test serodiagnostic method for Lyme disease in a seroepidemiologic study in an endemic area.","volume":"65","author":"Trevejo","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid1101.040303-202410292318-R17","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/infdis\/167.2.392","article-title":"Western blotting in the serodiagnosis of Lyme disease.","volume":"167","author":"Dressler","year":"1993","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R18","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1034\/j.1398-9995.2003.00211.x","article-title":"Bartolome. Anaphylaxis due to tick bite.","volume":"58","author":"Acero","year":"2003","journal-title":"Allergy"},{"key":"key-10.3201\/eid1101.040303-202410292318-R19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0169-4758(86)90055-4","article-title":"The physiology of itch.","volume":"2","author":"Alexander","year":"1986","journal-title":"Parasitol Today"},{"key":"key-10.3201\/eid1101.040303-202410292318-R20","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1093\/infdis\/167.5.1082","article-title":"Dynamics of Borrelia burgdorferi transmission by nymphal Ixodes dammini ticks.","volume":"167","author":"Piesman","year":"1993","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/oxfordjournals.aje.a008728","article-title":"Duration of tick bites in a Lyme disease-endemic area.","volume":"143","author":"Falco","year":"1996","journal-title":"Am J Epidemiol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R22","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1086\/514009","article-title":"Duration of tick attachment as a predictor of the risk of Lyme disease in an area in which Lyme disease is endemic.","volume":"175","author":"Sood","year":"1997","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1056\/NEJM200107123450201","article-title":"Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.","volume":"345","author":"Nadelman","year":"2001","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid1101.040303-202410292318-R24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/iai.65.1.335-338.1997","article-title":"Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks.","volume":"65","author":"Wikel","year":"1997","journal-title":"Infect Immun"},{"key":"key-10.3201\/eid1101.040303-202410292318-R25","doi-asserted-by":"crossref","first-page":"780","DOI":"10.4269\/ajtmh.1998.58.780","article-title":"Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.","volume":"58","author":"Nazario","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid1101.040303-202410292318-R26","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1128\/AEM.64.11.4596-4599.1998","article-title":"Effect of prior exposure to noninfected ticks on susceptibility of mice to Lyme disease spirochetes.","volume":"64","author":"Richter","year":"1998","journal-title":"Appl Environ Microbiol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R27","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004004834","article-title":"Tick immunobiology.","author":"Brossard","year":"2004","journal-title":"Parasitology"},{"key":"key-10.3201\/eid1101.040303-202410292318-R28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1353\/pbm.1974.0027","article-title":"Immediate hypersensitivity: A defense against arthropods.","volume":"17","author":"Stebbings","year":"1974","journal-title":"Perspect Biol Med"},{"key":"key-10.3201\/eid1101.040303-202410292318-R29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/oxfordjournals.aje.a115643","article-title":"Anti-tick antibodies: an epidemiologic tool in Lyme disease research.","volume":"132","author":"Schwartz","year":"1990","journal-title":"Am J Epidemiol"},{"key":"key-10.3201\/eid1101.040303-202410292318-R30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4269\/ajtmh.1993.48.50","article-title":"Entomologic and demographic correlates of anti-tick saliva antibody in a prospective study of tick bite subjects in Westchester County, New York.","volume":"48","author":"Schwartz","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid1101.040303-202410292318-R31","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.2105\/AJPH.83.12.1746","article-title":"Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers.","volume":"83","author":"Schwartz","year":"1993","journal-title":"Am J Public Health"},{"key":"key-10.3201\/eid1101.040303-202410292318-R32","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein.","volume":"194","author":"Valenzuela","year":"2001","journal-title":"J Exp Med"},{"key":"key-10.3201\/eid1101.040303-202410292318-R33","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1086\/344733","article-title":"Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity.","volume":"186","author":"Gomes","year":"2002","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/00006454-199001000-00003","article-title":"Lyme disease in childhood: clinical and epidemiologic features of ninety cases.","volume":"9","author":"Williams","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"key-10.3201\/eid1101.040303-202410292318-R35","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/infdis\/163.2.305","article-title":"The prevalence and incidence of clinical and asymptomatic Lyme borreliosis in a population at risk.","volume":"163","author":"Fahrer","year":"1991","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1101.040303-202410292318-R36","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1056\/NEJM199610243351703","article-title":"Bell GL and the Pediatric Lyme Disease Study Group. Lyme disease in children in southeastern Connecticut.","volume":"335","author":"Gerber","year":"1996","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid1101.040303-202410292318-R37","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3109\/00365549309008548","article-title":"Forsgren, Gardulf A, Granstrom M, Svenungsson B. Clinical manifestations and antibody prevalence of Lyme borreliosis and tick-borne encephalitis in Sweden: a study in five endemic areas close to Stockholm.","volume":"25","author":"Gustafson","year":"1993","journal-title":"Scand J Infect Dis"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/11\/1\/04-0303_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T09:00:37Z","timestamp":1732611637000},"score":1,"resource":{"primary":{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/11\/1\/04-0303_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"URL":"https:\/\/doi.org\/10.3201\/eid1101.040303","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}