{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:31:04Z","timestamp":1789205464347,"version":"build-2803163510"},"reference-count":32,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.3201\/eid1905.120274","type":"journal-article","created":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T16:24:39Z","timestamp":1364574279000},"page":"712-720","source":"Crossref","is-referenced-by-count":24,"title":["Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates"],"prefix":"10.3201","volume":"19","author":[{"given":"Edgar","family":"Holznagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Yutzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Schulz-Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Kruip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hahmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Bierke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Maria","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Thomzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Beekes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Hunsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Loewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid1905.120274-201304241132-R1","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/S0140-6736(96)91412-9","article-title":"A new variant of Creutzfeldt-Jakob disease in the UK.","volume":"347","author":"Will","year":"1996","journal-title":"Lancet"},{"key":"key-10.3201\/eid1905.120274-201304241132-R2","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/383685a0","article-title":"Molecular analysis of prion strain variation and the aetiology of \u2018new variant\u2019 CJD.","volume":"383","author":"Collinge","year":"1996","journal-title":"Nature"},{"key":"key-10.3201\/eid1905.120274-201304241132-R3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/39057","article-title":"Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent.","volume":"389","author":"Bruce","year":"1997","journal-title":"Nature"},{"key":"key-10.3201\/eid1905.120274-201304241132-R4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(05)17985-9","article-title":"Risk of oral infection with bovine spongiform encephalopathy agent in primates.","volume":"365","author":"Lasm\u00e9zas","year":"2005","journal-title":"Lancet"},{"key":"key-10.3201\/eid1905.120274-201304241132-R5","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1126\/science.1066838","article-title":"Estimation of epidemic size and incubation time based on age characteristics of vCJD in the United Kingdom.","volume":"294","author":"Valleron","year":"2001","journal-title":"Science"},{"key":"key-10.3201\/eid1905.120274-201304241132-R6","doi-asserted-by":"publisher","first-page":"10960","DOI":"10.1073\/pnas.1833677100","article-title":"Repeated challenge with prion disease: the risk of infection and impact on incubation period.","volume":"100","author":"Gravenor","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid1905.120274-201304241132-R7","unstructured":"Andrews NJ. Incidence of variant Creutzfeldt-Jakob disease diagnoses and death in the U.K. 2011. The National Creutzfeldt-Jakob Disease Research & Surveillance Unit [cited 2013 Feb 28]. http:\/\/www.cjd.ed.ac.uk\/documents\/cjdq72.pdf"},{"key":"key-10.3201\/eid1905.120274-201304241132-R8","unstructured":"Hunsmann G. Hahmann U, Motzkus D, Bierke P, Dormont D, Lazmezas CI, et al. BSE transmission through food and blood products: a study in primates to assess the risk for humans. 5th Framework Programme [cited 2013 Feb 28]. ftp:\/\/ftp.cordis.europa.eu\/pub\/fp7\/kbbe\/docs\/tse_ok-web.pdf"},{"key":"key-10.3201\/eid1905.120274-201304241132-R9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1474-4422(08)70265-5","article-title":"Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.","volume":"8","author":"Mead","year":"2009","journal-title":"Lancet Neurol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3378\/1534-6617(2008)80[181:PDOTMA]2.0.CO;2","article-title":"Population distribution of the methionine allele at the PRNP codon 129 polymorphism in Europe and the Middle East.","volume":"80","author":"Mercier","year":"2008","journal-title":"Hum Biol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R11","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1136\/bmj.38804.511644.55","article-title":"Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study.","volume":"332","author":"Ironside","year":"2006","journal-title":"BMJ"},{"key":"key-10.3201\/eid1905.120274-201304241132-R12","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/S0140-6736(09)61568-3","article-title":"Variant CJD in an individual heterozygous for PRNP codon 129.","volume":"374","author":"Kaski","year":"2009","journal-title":"Lancet"},{"key":"key-10.3201\/eid1905.120274-201304241132-R13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1099\/0022-1317-79-3-609","article-title":"Effect of repeated oral infection of hamsters with scrapie.","volume":"79","author":"Diringer","year":"1998","journal-title":"J Gen Virol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2353\/ajpath.2006.050766","article-title":"Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.","volume":"168","author":"Yull","year":"2006","journal-title":"Am J Pathol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R15","doi-asserted-by":"publisher","first-page":"10168","DOI":"10.1073\/pnas.97.18.10168","article-title":"Genetic influence on the structural variations of the abnormal prion protein.","volume":"97","author":"Parchi","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid1905.120274-201304241132-R16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","article-title":"Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects.","volume":"46","author":"Parchi","year":"1999","journal-title":"Ann Neurol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R17","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1093\/brain\/awl224","article-title":"Classification of sporadic Creutzfeldt-Jakob disease revisited.","volume":"129","author":"Cali","year":"2006","journal-title":"Brain"},{"key":"key-10.3201\/eid1905.120274-201304241132-R18","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S1474-4422(05)70225-8","article-title":"Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease.","volume":"4","author":"Polymenidou","year":"2005","journal-title":"Lancet Neurol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R19","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1093\/brain\/awp196","article-title":"Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.","volume":"132","author":"Cali","year":"2009","journal-title":"Brain"},{"key":"key-10.3201\/eid1905.120274-201304241132-R20","doi-asserted-by":"publisher","first-page":"40429","DOI":"10.1074\/jbc.M308550200","article-title":"Identification of novel proteinase K\u2013resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.","volume":"278","author":"Zou","year":"2003","journal-title":"J Biol Chem"},{"key":"key-10.3201\/eid1905.120274-201304241132-R21","doi-asserted-by":"publisher","first-page":"30557","DOI":"10.1074\/jbc.M801877200","article-title":"Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease.","volume":"283","author":"Notari","year":"2008","journal-title":"J Biol Chem"},{"key":"key-10.3201\/eid1905.120274-201304241132-R22","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1099\/vir.0.83128-0","article-title":"Time-course studies of 14\u20133-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent.","volume":"88","author":"Yutzy","year":"2007","journal-title":"J Gen Virol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R23","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00705-002-0958-4","article-title":"Early detection of PrPres in BSE-infected bovine transgenic mice.","volume":"148","author":"Castilla","year":"2003","journal-title":"Arch Virol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0002-9440(10)64705-0","article-title":"The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases.","volume":"156","author":"Schulz-Schaeffer","year":"2000","journal-title":"Am J Pathol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R25","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1537-2995.2009.02437.x","article-title":"Increase in CD230 (cellular prion protein) fluorescence on blood lymphocytes in bovine spongiform encephalopathy\u2013infected nonhuman primates.","volume":"50","author":"Holznagel","year":"2010","journal-title":"Transfusion"},{"key":"key-10.3201\/eid1905.120274-201304241132-R26","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1089\/hyb.2006.25.271","article-title":"Generation of monoclonal antibody recognized by the GXXXG motif (glycine zipper) of prion protein.","volume":"25","author":"Choi","year":"2006","journal-title":"Hybridoma (Larchmt)"},{"key":"key-10.3201\/eid1905.120274-201304241132-R27","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/path.2767","article-title":"Large-scale immunohistochemical examination for lymphoreticular prion protein in tonsil specimens collected in Britain.","volume":"222","author":"de Marco","year":"2010","journal-title":"J Pathol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/path.1580","article-title":"Prevalence of lymphoreticular prion protein accumulation in UK tissue samples.","volume":"203","author":"Hilton","year":"2004","journal-title":"J Pathol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R29","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1118155","article-title":"Reciprocal interference between specific CJD and scrapie agents in neural cell cultures.","volume":"310","author":"Nishida","year":"2005","journal-title":"Science"},{"key":"key-10.3201\/eid1905.120274-201304241132-R30","doi-asserted-by":"publisher","first-page":"5706","DOI":"10.1128\/JVI.00243-10","article-title":"Coinfecting prion strains compete for a limiting cellular resource.","volume":"84","author":"Shikiya","year":"2010","journal-title":"J Virol"},{"key":"key-10.3201\/eid1905.120274-201304241132-R31","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1016\/S0021-9258(17)42989-9","article-title":"Phosphorylation affects the ability of tau protein to promote microtubule assembly.","volume":"259","author":"Lindwall","year":"1984","journal-title":"J Biol Chem"},{"key":"key-10.3201\/eid1905.120274-201304241132-R32","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.3201\/eid1509.090253","article-title":"Susceptibilities of nonhuman primates to chronic wasting disease.","volume":"15","author":"Race","year":"2009","journal-title":"Emerg Infect Dis"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/19\/5\/12-0274_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T04:19:59Z","timestamp":1733285999000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/19\/5\/12-0274_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"URL":"https:\/\/doi.org\/10.3201\/eid1905.120274","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}