{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:26:59Z","timestamp":1790627219674,"version":"4.1.0"},"reference-count":40,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.3201\/eid1905.121845","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T17:02:18Z","timestamp":1362589338000},"page":"729-735","source":"Crossref","is-referenced-by-count":143,"title":["World Health Organization International Standard to Harmonize Assays for Detection of Hepatitis E Virus RNA"],"prefix":"10.3201","volume":"19","author":[{"given":"Sally A.","family":"Baylis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Bl\u00fcmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Mizusawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Matsubayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekatsu","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Micha","family":"N\u00fcbling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Martin O.","family":"Hanschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the HEV Collaborative Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid1905.121845-201303291336-R1","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1016\/S0140-6736(11)61849-7","article-title":"Hepatitis E.","volume":"379","author":"Kamar","year":"2012","journal-title":"Lancet"},{"key":"key-10.3201\/eid1905.121845-201303291336-R2","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1056\/NEJMra1204512","volume":"367","author":"Hoofnagle","year":"2012","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid1905.121845-201303291336-R3","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jcv.2009.01.005","article-title":"Indigenous hepatitis E virus infection in England: more common than it seems.","volume":"44","author":"Ijaz","year":"2009","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R4","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1056\/NEJMoa061847","article-title":"Safety and efficacy of a recombinant hepatitis E vaccine.","volume":"356","author":"Shrestha","year":"2007","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid1905.121845-201303291336-R5","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(10)61030-6","article-title":"Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial.","volume":"376","author":"Zhu","year":"2010","journal-title":"Lancet"},{"key":"key-10.3201\/eid1905.121845-201303291336-R6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1086\/655898","article-title":"Pig liver sausage as a source of hepatitis E virus transmission to humans.","volume":"202","author":"Colson","year":"2010","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid1905.121845-201303291336-R7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jcv.2011.06.006","article-title":"Detection of hepatitis E virus (HEV) from porcine livers in southeastern Germany and high sequence homology to human HEV isolates.","volume":"52","author":"Wenzel","year":"2011","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R8","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.3201\/eid1812.120924","article-title":"Identification of hepatitis E virus genotype 3 in shellfish in the United Kingdom.","volume":"18","author":"Crossan","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid1905.121845-201303291336-R9","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1111\/j.1537-2995.2004.03300.x","article-title":"Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan.","volume":"44","author":"Matsubayashi","year":"2004","journal-title":"Transfusion"},{"key":"key-10.3201\/eid1905.121845-201303291336-R10","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/j.1537-2995.2008.01722.x","article-title":"A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route.","volume":"48","author":"Matsubayashi","year":"2008","journal-title":"Transfusion"},{"key":"key-10.3201\/eid1905.121845-201303291336-R11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-3148.2006.00652.x","article-title":"Transfusion-transmitted hepatitis E in a \u201cnonhyperendemic\u201d country.","volume":"16","author":"Boxall","year":"2006","journal-title":"Transfus Med"},{"key":"key-10.3201\/eid1905.121845-201303291336-R12","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3201\/eid1304.061387","article-title":"Transfusion-associated hepatitis E, France.","volume":"13","author":"Colson","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid1905.121845-201303291336-R13","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.jhep.2012.08.001","article-title":"Transfusion-transmitted hepatitis E in a misleading context of autoimmunity and drug-induced toxicity.","volume":"57","author":"Ha\u00efm-Boukobza","year":"2012","journal-title":"J Hepatol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R14","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1111\/j.1537-2995.2008.01910.x","article-title":"A nationwide survey for hepatitis E virus prevalence in Japanese blood donors with elevated alanine aminotransferase.","volume":"48","author":"Sakata","year":"2008","journal-title":"Transfusion"},{"key":"key-10.3201\/eid1905.121845-201303291336-R15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1128\/JCM.01466-09","article-title":"Prevalence of hepatitis E virus in Chinese blood donors.","volume":"48","author":"Guo","year":"2010","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1423-0410.2009.01211.x","article-title":"Indigenous hepatitis E virus infection of a plasma donor in Germany.","volume":"97","author":"Adlhoch","year":"2009","journal-title":"Vox Sang"},{"key":"key-10.3201\/eid1905.121845-201303291336-R17","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1423-0410.2011.01527.x","article-title":"Widespread distribution of hepatitis E virus in plasma fractionation pools.","volume":"102","author":"Baylis","year":"2012","journal-title":"Vox Sang"},{"key":"key-10.3201\/eid1905.121845-201303291336-R18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1423-0410.2011.01583.x","article-title":"Occurrence of hepatitis E virus RNA in plasma donations from Sweden, Germany and the United States.","volume":"103","author":"Baylis","year":"2012","journal-title":"Vox Sang"},{"key":"key-10.3201\/eid1905.121845-201303291336-R19","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1128\/JCM.01119-12","article-title":"A novel approach for the detection of hepatitis E virus infection in German blood donors.","volume":"50","author":"Vollmer","year":"2012","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R20","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1423-0410.2012.01638.x","article-title":"Zoonotic hepatitis E virus strains in German blood donors.","volume":"104","author":"Corman","year":"2013","journal-title":"Vox Sang"},{"key":"key-10.3201\/eid1905.121845-201303291336-R21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1423-0410.2011.01554.x","article-title":"Detection of hepatitis E virus RNA in plasma mini-pools from blood donors in England.","volume":"102","author":"Ijaz","year":"2012","journal-title":"Vox Sang"},{"key":"key-10.3201\/eid1905.121845-201303291336-R22","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.jhep.2011.06.021","article-title":"Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient.","volume":"56","author":"Schlosser","year":"2012","journal-title":"J Hepatol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R23","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1053\/j.gastro.2011.07.051","article-title":"Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.","volume":"141","author":"Davern","year":"2011","journal-title":"Gastroenterology"},{"key":"key-10.3201\/eid1905.121845-201303291336-R24","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1056\/NEJMoa0706992","article-title":"Hepatitis E virus and chronic hepatitis in organ-transplant recipients.","volume":"358","author":"Kamar","year":"2008","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid1905.121845-201303291336-R25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/lt.22014","article-title":"Treatment of chronic hepatitis E in liver transplant recipients with pegylated interferon alpha-2b.","volume":"16","author":"Haagsma","year":"2010","journal-title":"Liver Transpl"},{"key":"key-10.3201\/eid1905.121845-201303291336-R26","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1053\/j.gastro.2010.08.002","article-title":"Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection.","volume":"139","author":"Kamar","year":"2010","journal-title":"Gastroenterology"},{"key":"key-10.3201\/eid1905.121845-201303291336-R27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/TP.0b013e3181c4096c","article-title":"Influence of immunosuppressive therapy on the natural history of genotype 3 hepatitis E virus infection after organ transplantation.","volume":"89","author":"Kamar","year":"2010","journal-title":"Transplantation"},{"key":"key-10.3201\/eid1905.121845-201303291336-R28","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/jmv.21656","article-title":"A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV seroprevalence data in developed countries.","volume":"82","author":"Bendall","year":"2010","journal-title":"J Med Virol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R29","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1086\/654801","article-title":"Serological assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.","volume":"51","author":"Drobeniuc","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid1905.121845-201303291336-R30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jcv.2012.09.010","article-title":"Discrepancy between anti-hepatitis E virus immunoglobulin G prevalence assessed by two assays in kidney and liver transplant recipients.","volume":"56","author":"Rossi-Tamisier","year":"2013","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R31","doi-asserted-by":"publisher","first-page":"e13560","DOI":"10.1371\/journal.pone.0013560","article-title":"Profile of acute infectious markers in sporadic hepatitis E.","volume":"5","author":"Huang","year":"2010","journal-title":"PLoS ONE"},{"key":"key-10.3201\/eid1905.121845-201303291336-R32","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1006\/viro.2001.1093","article-title":"Identification and characterization of the neutralization epitope(s) of the hepatitis E virus.","volume":"288","author":"Meng","year":"2001","journal-title":"Virology"},{"key":"key-10.3201\/eid1905.121845-201303291336-R33","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1128\/JCM.00498-09","article-title":"Reverse transcription-loop-mediated isothermal amplification assay for rapid detection of hepatitis E virus.","volume":"47","author":"Lan","year":"2009","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jviromet.2005.07.004","article-title":"A broadly reactive one-step real-time RT-PCR assay for rapid and sensitive detection of hepatitis E virus.","volume":"131","author":"Jothikumar","year":"2006","journal-title":"J Virol Methods"},{"key":"key-10.3201\/eid1905.121845-201303291336-R35","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jviromet.2007.07.014","article-title":"Universal detection of hepatitis E virus by two real-time PCR assays: TaqMan and Primer-Probe Energy Transfer.","volume":"146","author":"Gyarmati","year":"2007","journal-title":"J Virol Methods"},{"key":"key-10.3201\/eid1905.121845-201303291336-R36","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1128\/JCM.02578-10","article-title":"Standardization of hepatitis E virus (HEV) nucleic acid amplification technique-based assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance.","volume":"49","author":"Baylis","year":"2011","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1006\/viro.2001.1017","article-title":"Full-genome nucleotide sequence of a hepatitis E virus strain that may be indigenous to Japan.","volume":"287","author":"Takahashi","year":"2001","journal-title":"Virology"},{"key":"key-10.3201\/eid1905.121845-201303291336-R38","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol Biol Evol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R39","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/rmv.482","article-title":"Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis.","volume":"16","author":"Lu","year":"2006","journal-title":"Rev Med Virol"},{"key":"key-10.3201\/eid1905.121845-201303291336-R40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jviromet.2012.07.027","article-title":"Minor groove binder modification of widely used TaqMan probe for hepatitis E virus reduces risk of false negative real-time PCR results.","volume":"186","author":"Garson","year":"2012","journal-title":"J Virol Methods"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/19\/5\/12-1845_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:22:08Z","timestamp":1745968928000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/19\/5\/12-1845_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"URL":"https:\/\/doi.org\/10.3201\/eid1905.121845","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}