{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:44:55Z","timestamp":1790624695558,"version":"4.1.0"},"reference-count":39,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.3201\/eid2107.150522","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T02:43:34Z","timestamp":1429757014000},"page":"1135-1143","source":"Crossref","is-referenced-by-count":82,"title":["Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia"],"prefix":"10.3201","volume":"21","author":[{"given":"Jeffrey R.","family":"Kugelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Mate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"Ladner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Beitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Fakoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahn","family":"Taweh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Diclaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Minogue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal J.","family":"Schoepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt E.","family":"Schaecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Pettitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens H.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hensley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis C.","family":"Sabeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanchez-Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatorma K.","family":"Bolay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of US Army Medical Research Institute of Infectious Diseases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"National Institutes of Health","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Integrated Research Facility\u2013Frederick Ebola Response Team 2014\u20132015","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2107.150522-201506120959-R1","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1056\/NEJMoa1404505","article-title":"Emergence of Zaire Ebola virus disease in Guinea\u2014preliminary report.","volume":"371","author":"Baize","year":"2014","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2107.150522-201506120959-R2","doi-asserted-by":"publisher","first-page":"g5089","DOI":"10.1136\/bmj.g5089","article-title":"Ebola outbreak is a public health emergency of international concern, WHO warns.","volume":"349","author":"Hawkes","year":"2014","journal-title":"BMJ"},{"key":"key-10.3201\/eid2107.150522-201506120959-R3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/518477a","article-title":"Data sharing: make outbreak research open access.","volume":"518","author":"Yozwiak","year":"2015","journal-title":"Nature"},{"key":"key-10.3201\/eid2107.150522-201506120959-R4","unstructured":"World Health Organization. Ebola situation report\u201411 March 2015 [cited 2015 Mar 30]. http:\/\/apps.who.int\/ebola\/current-situation\/ebola-situation-report-11-march-2015"},{"key":"key-10.3201\/eid2107.150522-201506120959-R5","unstructured":"Chan M. WHO report by the Director-General to the special session of the Executive Board on Ebola [cited 2015 Mar 30]. http:\/\/www.who.int\/dg\/speeches\/2015\/executive-board-ebola\/en\/"},{"key":"key-10.3201\/eid2107.150522-201506120959-R6","doi-asserted-by":"publisher","first-page":"e02227","DOI":"10.1128\/mBio.02227-14","article-title":"Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics.","volume":"6","author":"Kugelman","year":"2015","journal-title":"MBio"},{"key":"key-10.3201\/eid2107.150522-201506120959-R7","doi-asserted-by":"publisher","first-page":"E527","DOI":"10.1503\/cmaj.109-4893","article-title":"WHO enters new terrain in Ebola research.","volume":"186","author":"Shuchman","year":"2014","journal-title":"CMAJ"},{"key":"key-10.3201\/eid2107.150522-201506120959-R8","doi-asserted-by":"publisher","first-page":"g5161","DOI":"10.1136\/bmj.g5161","article-title":"WHO gives go ahead for experimental treatments to be used in Ebola outbreak.","volume":"349","author":"Sayburn","year":"2014","journal-title":"BMJ"},{"key":"key-10.3201\/eid2107.150522-201506120959-R9","doi-asserted-by":"publisher","first-page":"954","DOI":"10.4269\/ajtmh.2010.09-0636","article-title":"Comprehensive panel of real-time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses.","volume":"82","author":"Trombley","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid2107.150522-201506120959-R10","doi-asserted-by":"publisher","first-page":"4760","DOI":"10.3390\/v6114760","article-title":"Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014.","volume":"6","author":"Kuhn","year":"2014","journal-title":"Viruses"},{"key":"key-10.3201\/eid2107.150522-201506120959-R11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2164-9-5","article-title":"Viral genome sequencing by random priming methods.","volume":"9","author":"Djikeng","year":"2008","journal-title":"BMC Genomics"},{"key":"key-10.3201\/eid2107.150522-201506120959-R12","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1126\/science.1259657","article-title":"Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.","volume":"345","author":"Gire","year":"2014","journal-title":"Science"},{"key":"key-10.3201\/eid2107.150522-201506120959-R13","first-page":"10","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads.","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnetjournal."},{"key":"key-10.3201\/eid2107.150522-201506120959-R14","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1093\/bioinformatics\/btr026","article-title":"Quality control and preprocessing of metagenomic datasets.","volume":"27","author":"Schmieder","year":"2011","journal-title":"Bioinformatics"},{"key":"key-10.3201\/eid2107.150522-201506120959-R15","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools.","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"key-10.3201\/eid2107.150522-201506120959-R16","doi-asserted-by":"crossref","unstructured":"Cingolani P, Platts A. Wang le L, Coon M, Nguyen T, Wang L, et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome ofDrosophila melanogasterstrain w1118; iso-2; iso-3. Fly (Austin). 2012;6:80\u201392.","DOI":"10.4161\/fly.19695"},{"key":"key-10.3201\/eid2107.150522-201506120959-R17","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1093\/molbev\/mss075","article-title":"Bayesian phylogenetics with BEAUti and the BEAST 1.7.","volume":"29","author":"Drummond","year":"2012","journal-title":"Mol Biol Evol"},{"key":"key-10.3201\/eid2107.150522-201506120959-R18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/sysbio\/syq010","article-title":"New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.","volume":"59","author":"Guindon","year":"2010","journal-title":"Syst Biol"},{"key":"key-10.3201\/eid2107.150522-201506120959-R19","doi-asserted-by":"publisher","first-page":"e01360","DOI":"10.1128\/mBio.01360-14","article-title":"Standards for sequencing viral genomes in the era of high-throughput sequencing.","volume":"5","author":"Ladner","year":"2014","journal-title":"MBio"},{"key":"key-10.3201\/eid2107.150522-201506120959-R20","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/S0140-6736(10)60357-1","article-title":"Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study.","volume":"375","author":"Geisbert","year":"2010","journal-title":"Lancet"},{"key":"key-10.3201\/eid2107.150522-201506120959-R21","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nm.2202","article-title":"Advanced antisense therapies for postexposure protection against lethal filovirus infections.","volume":"16","author":"Warren","year":"2010","journal-title":"Nat Med"},{"key":"key-10.3201\/eid2107.150522-201506120959-R22","doi-asserted-by":"crossref","unstructured":"Qiu X, Audet J, Wong G, Fernando L, Bello A, Pillet S, Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb. Sci Rep. 2013;3:3365.","DOI":"10.1038\/srep03365"},{"key":"key-10.3201\/eid2107.150522-201506120959-R23","doi-asserted-by":"crossref","unstructured":"Pettitt J, Zeitlin L, Kim DH, Working C, Johnson JC, Bohorov O, Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail. Sci Transl Med. 2013;5:199ra113.PMID: 23966302","DOI":"10.1126\/scitranslmed.3006608"},{"key":"key-10.3201\/eid2107.150522-201506120959-R24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"},{"key":"key-10.3201\/eid2107.150522-201506120959-R25","doi-asserted-by":"publisher","first-page":"18030","DOI":"10.1073\/pnas.1213709109","article-title":"Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.","volume":"109","author":"Olinger","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2107.150522-201506120959-R26","doi-asserted-by":"publisher","first-page":"5034","DOI":"10.1073\/pnas.1200409109","article-title":"Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease.","volume":"109","author":"Dye","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2107.150522-201506120959-R27","doi-asserted-by":"publisher","first-page":"6639","DOI":"10.1128\/AAC.03442-14","article-title":"Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against Ebola virus and Marburg virus: results of two single-ascending-dose studies.","volume":"58","author":"Heald","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2107.150522-201506120959-R28","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00705-012-1454-0","article-title":"Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae.","volume":"158","author":"Kuhn","year":"2013","journal-title":"Arch Virol"},{"key":"key-10.3201\/eid2107.150522-201506120959-R29","unstructured":"Rezler JP. Tekmira provides periodic update on TKM-Ebola program [cited 2015 Mar 30]. http:\/\/investor.tekmirapharm.com\/releasedetail.cfm?ReleaseID=877397"},{"key":"key-10.3201\/eid2107.150522-201506120959-R30","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1126\/science.287.5458.1664","article-title":"Epitopes involved in antibody-mediated protection from Ebola virus.","volume":"287","author":"Wilson","year":"2000","journal-title":"Science"},{"key":"key-10.3201\/eid2107.150522-201506120959-R31","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.clim.2011.08.008","article-title":"Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies.","volume":"141","author":"Qiu","year":"2011","journal-title":"Clin Immunol"},{"key":"key-10.3201\/eid2107.150522-201506120959-R32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.virol.2004.10.048","article-title":"Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening.","volume":"332","author":"Towner","year":"2005","journal-title":"Virology"},{"key":"key-10.3201\/eid2107.150522-201506120959-R33","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1128\/AAC.00936-08","article-title":"Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.","volume":"53","author":"Swenson","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2107.150522-201506120959-R34","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1086\/504267","article-title":"Postexposure protection of guinea pigs against a lethal Ebola virus challenge is conferred by RNA interference.","volume":"193","author":"Geisbert","year":"2006","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2107.150522-201506120959-R35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.virusres.2004.06.002","article-title":"Rescue of Ebola virus from cDNA using heterologous support proteins.","volume":"106","author":"Theriault","year":"2004","journal-title":"Virus Res"},{"key":"key-10.3201\/eid2107.150522-201506120959-R36","doi-asserted-by":"publisher","first-page":"12569","DOI":"10.1128\/JVI.01395-08","article-title":"Role of Ebola virus VP30 in transcription reinitiation.","volume":"82","author":"Mart\u00ednez","year":"2008","journal-title":"J Virol"},{"key":"key-10.3201\/eid2107.150522-201506120959-R37","doi-asserted-by":"publisher","first-page":"11165","DOI":"10.1074\/jbc.M113.461285","article-title":"Phosphorylation of Ebola virus VP30 influences the composition of the viral nucleocapsid complex: impact on viral transcription and replication.","volume":"288","author":"Biedenkopf","year":"2013","journal-title":"J Biol Chem"},{"key":"key-10.3201\/eid2107.150522-201506120959-R38","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1128\/JVI.03118-12","article-title":"Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences.","volume":"87","author":"Carroll","year":"2013","journal-title":"J Virol"},{"key":"key-10.3201\/eid2107.150522-201506120959-R39","unstructured":"World Health Organization. Mali: details of the additional cases of Ebola virus disease [cited 2015 Mar 30]. http:\/\/www.who.int\/mediacentre\/news\/ebola\/20-november-2014-mali\/en\/"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/21\/7\/15-0522_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T23:21:53Z","timestamp":1732922513000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/21\/7\/15-0522_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2107.150522","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}