{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:35:20Z","timestamp":1782578120289,"version":"3.54.5"},"reference-count":40,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.3201\/eid2111.142029","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T18:51:13Z","timestamp":1443552673000},"page":"1956-1965","source":"Crossref","is-referenced-by-count":66,"title":["Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010\u20132013"],"prefix":"10.3201","volume":"21","author":[{"given":"Kimiko","family":"Ubukata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Morozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Wajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michi","family":"Shouji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Invasive Pneumococcal Diseases Surveillance Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2111.142029-201510151226-R1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1086\/518538","article-title":"Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study.","volume":"45","author":"Alanee","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R2","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1093\/cid\/cis971","article-title":"Epidemiology of invasive pneumococcal disease among high-risk adults since the introduction of pneumococcal conjugate vaccine for children.","volume":"56","author":"Muhammad","year":"2013","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R3","first-page":"1102","article-title":"Updated recommendations for prevention of invasive pneumococcal disease among adults using the 23-valent pneumococcal polysaccharide vaccine (PPSV23).","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2111.142029-201510151226-R4","first-page":"816","article-title":"Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP).","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2111.142029-201510151226-R5","first-page":"822","article-title":"Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged \u226565 years: recommendations of the Advisory Committee on Immunization Practices (ACIP).","volume":"63","author":"Tomczyk","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2111.142029-201510151226-R6","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/NEJMoa022823","article-title":"Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine.","volume":"348","author":"Whitney","year":"2003","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2111.142029-201510151226-R7","first-page":"893","article-title":"Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease\u2014United States, 1998\u20132003.","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2111.142029-201510151226-R8","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1086\/528996","article-title":"Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005.","volume":"197","author":"Moore","year":"2008","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1086\/648593","article-title":"Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine.","volume":"201","author":"Pilishvili","year":"2010","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/cid\/cir326","article-title":"Geographic variation in invasive pneumococcal disease following pneumococcal conjugate vaccine introduction in the United States.","volume":"53","author":"Rosen","year":"2011","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R11","first-page":"258","article-title":"Licensure of a 13-valent pneumococcal conjugate vaccine (PCV13) and recommendations for use among children\u2014Advisory Committee on Immunization Practices (ACIP), 2010.","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2111.142029-201510151226-R12","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1001\/jama.294.16.2043","article-title":"Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine.","volume":"294","author":"Lexau","year":"2005","journal-title":"JAMA"},{"key":"key-10.3201\/eid2111.142029-201510151226-R13","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1086\/650496","article-title":"Increased penicillin nonsusceptibility of nonvaccine-serotype invasive pneumococci other than serotypes 19A and 6A in post\u20137-valent conjugate vaccine era.","volume":"201","author":"Gertz","year":"2010","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R14","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3201\/eid1907.121830","article-title":"Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999\u20132011.","volume":"19","author":"Richter","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R15","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/S1473-3099(11)70090-1","article-title":"Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study.","volume":"11","author":"Miller","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R16","doi-asserted-by":"publisher","first-page":"6232","DOI":"10.1016\/j.vaccine.2013.10.032","article-title":"Prompt effect of replacing the 7-valent pneumococcal conjugate vaccine with the 13-valent vaccine on the epidemiology of invasive pneumococcal disease in Norway.","volume":"31","author":"Steens","year":"2013","journal-title":"Vaccine"},{"key":"key-10.3201\/eid2111.142029-201510151226-R17","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1093\/infdis\/jiu213","article-title":"Reduction of invasive pneumococcal disease 3 years after the introduction of the 13-valent conjugate vaccine in the Oxfordshire region of England.","volume":"210","author":"Moore","year":"2014","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R18","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1093\/cid\/ciu524","article-title":"Impact of 13-valent pneumococcal conjugate vaccination in invasive pneumococcal disease incidence and mortality.","volume":"59","author":"Harboe","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R19","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.3201\/eid2007.131485","article-title":"Changes in capsule and drug resistance of pneumococci after introduction of PCV7, Japan, 2010\u20132013.","volume":"20","author":"Chiba","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R20","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference.","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"key-10.3201\/eid2111.142029-201510151226-R21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1089\/mdr.2011.0102","article-title":"Application of the real-time PCR method for genotypic identification of beta-lactam resistance in isolates from invasive pneumococcal diseases.","volume":"18","author":"Chiba","year":"2012","journal-title":"Microb Drug Resist"},{"key":"key-10.3201\/eid2111.142029-201510151226-R22","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1128\/AAC.40.10.2321","article-title":"Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae.","volume":"40","author":"Pan","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2111.142029-201510151226-R23","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. Vol. 31. Document M100-S21. Wayne (PA): The Institute; 2011."},{"key":"key-10.3201\/eid2111.142029-201510151226-R24","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s10156-010-0180-3","article-title":"Molecular epidemiologic characteristics of Streptococcus pneumoniae isolates from children with meningitis in Japan from 2007 through 2009.","volume":"17","author":"Sakai","year":"2011","journal-title":"J Infect Chemother"},{"key":"key-10.3201\/eid2111.142029-201510151226-R25","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1056\/NEJMoa1209165","article-title":"Grijalva CG. U.S. hospitalizations for pneumonia after a decade of pneumococcal vaccination.","volume":"369","author":"Griffin","year":"2013","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2111.142029-201510151226-R26","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1093\/cid\/ciu006","article-title":"Early impact of 13-valent pneumococcal conjugate vaccine on community-acquired pneumonia in children.","volume":"58","author":"Angoulvant","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R27","doi-asserted-by":"publisher","first-page":"8042","DOI":"10.1016\/j.vaccine.2011.08.057","article-title":"Modeling the decline in pneumococcal acute otitis media following the introduction of pneumococcal conjugate vaccines in the US.","volume":"29","author":"Shea","year":"2011","journal-title":"Vaccine"},{"key":"key-10.3201\/eid2111.142029-201510151226-R28","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1093\/cid\/cis292","article-title":"Impact of pneumococcal conjugate vaccination on otitis media: a systematic review.","volume":"54","author":"Taylor","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R29","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1056\/NEJMoa051642","article-title":"Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae.","volume":"354","author":"Kyaw","year":"2006","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2111.142029-201510151226-R30","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1056\/NEJMoa0800836","article-title":"Effect of pneumococcal conjugate vaccine on pneumococcal meningitis.","volume":"360","author":"Hsu","year":"2009","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2111.142029-201510151226-R31","doi-asserted-by":"publisher","first-page":"6484","DOI":"10.1128\/AAC.03344-14","article-title":"Changes in pneumococcal serotypes and antimicrobial resistance after introduction of the 13-valent conjugate vaccine in the United States.","volume":"58","author":"Richter","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.3201\/eid2111.142029-201510151226-R32","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/infdis\/jir755","article-title":"Prevention of antibiotic-nonsusceptible Streptococcus pneumoniae with conjugate vaccines.","volume":"205","author":"Hampton","year":"2012","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1086\/341072","article-title":"Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United States.","volume":"186","author":"Beall","year":"2002","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R34","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1128\/JCM.02628-10","article-title":"Comparison of capsular genes of Streptococcus pneumoniae serotype 6A, 6B, 6C, and 6D isolates.","volume":"49","author":"Song","year":"2011","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2111.142029-201510151226-R35","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1128\/JCM.05895-11","article-title":"Multidrug\u2013resistant Streptococcus pneumoniae serotype 6D clones in South Korea.","volume":"50","author":"Ko","year":"2012","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2111.142029-201510151226-R36","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.1128\/JCM.43.11.5440-5444.2005","article-title":"Clonal association between Streptococcus pneumoniae serotype 23A, circulating within the United States, and an internationally dispersed clone of serotype 23F.","volume":"43","author":"Pai","year":"2005","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2111.142029-201510151226-R37","doi-asserted-by":"publisher","first-page":"e168","DOI":"10.1371\/journal.ppat.0030168","article-title":"Vaccine escape recombinants emerge after pneumococcal vaccination in the United States.","volume":"3","author":"Brueggemann","year":"2007","journal-title":"PLoS Pathog"},{"key":"key-10.3201\/eid2111.142029-201510151226-R38","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1128\/JCM.05895-11","article-title":"Multidrug\u2013resistant Streptococcus pneumoniae serotype 6D clones in South Korea.","volume":"50","author":"Ko","year":"2012","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2111.142029-201510151226-R39","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/cid\/cit800","article-title":"Pneumococcal serotype diversity among adults in various countries, influenced by pediatric pneumococcal vaccination uptake.","volume":"58","author":"Grabenstein","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2111.142029-201510151226-R40","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3390\/vaccines2010112","article-title":"Towards new broader spectrum pneumococcal vaccines: the future of pneumococcal disease prevention.","volume":"2","author":"Lee","year":"2014","journal-title":"Vaccines."}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/21\/11\/14-2029_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T23:18:58Z","timestamp":1732922338000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/21\/11\/14-2029_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2111.142029","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}