{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:30Z","timestamp":1791295710727,"version":"4.1.0"},"reference-count":40,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3201\/eid2303.161499","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T15:48:29Z","timestamp":1481557709000},"page":"405-414","source":"Crossref","is-referenced-by-count":204,"title":["Zika Virus RNA Replication and Persistence in Brain and Placental Tissue"],"prefix":"10.3201","volume":"23","author":[{"given":"Julu","family":"Bhatnagar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demi B.","family":"Rabeneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosecelis B.","family":"Martines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Reagan-Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yokabed","family":"Ermias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey B.C.","family":"Estetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kelly","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Gary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atis","family":"Muehlenbachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lanciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titilope","family":"Oduyebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Meaney-Delman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bola\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Alberto Parra","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wun-Ju","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif R.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2303.161499-201702140826-R1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.15585\/mmwr.mm6503e1","article-title":"Zika virus spreads to new areas\u2014region of the Americas, May 2015\u2013January 2016.","volume":"65","author":"Hennessey","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2303.161499-201702140826-R2","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects\u2014reviewing the evidence for causality.","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2303.161499-201702140826-R3","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/S0140-6736(16)00651-6","article-title":"Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study.","volume":"387","author":"Cauchemez","year":"2016","journal-title":"Lancet"},{"key":"key-10.3201\/eid2303.161499-201702140826-R4","doi-asserted-by":"publisher","first-page":"514","DOI":"10.15585\/mmwr.mm6520e1","article-title":"Possible Zika virus infection among pregnant women\u2013United States and Territories, May 2016.","volume":"65","author":"Simeone","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2303.161499-201702140826-R5","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study.","volume":"16","author":"Calvet","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R6","doi-asserted-by":"publisher","first-page":"e0004517","DOI":"10.1371\/journal.pntd.0004517","article-title":"Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise.","volume":"10","author":"Sarno","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R7","doi-asserted-by":"publisher","first-page":"NEJMoa1602412","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro\u2014preliminary report.","author":"Brasil","year":"2016 Mar 4 [Epub ahead of print].","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2303.161499-201702140826-R8","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika virus infects human cortical neural progenitors and attenuates their growth.","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"key-10.3201\/eid2303.161499-201702140826-R9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models.","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"key-10.3201\/eid2303.161499-201702140826-R10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","article-title":"Zika virus disrupts neural progenitor development and leads to microcephaly in mice.","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"key-10.3201\/eid2303.161499-201702140826-R11","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus impairs growth in human neurospheres and brain organoids.","volume":"352","author":"Garcez","year":"2016","journal-title":"Science"},{"key":"key-10.3201\/eid2303.161499-201702140826-R12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.chom.2016.05.015","article-title":"Zika virus infects human placental macrophages.","volume":"20","author":"Quicke","year":"2016","journal-title":"Cell Host Microbe"},{"key":"key-10.3201\/eid2303.161499-201702140826-R13","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.chom.2016.03.008","article-title":"Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection.","volume":"19","author":"Bayer","year":"2016","journal-title":"Cell Host Microbe"},{"key":"key-10.3201\/eid2303.161499-201702140826-R14","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise.","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"key-10.3201\/eid2303.161499-201702140826-R15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.chom.2016.06.013","article-title":"Placental mechanics in the Zika-microcephaly relationship.","volume":"20","author":"Adibi","year":"2016","journal-title":"Cell Host Microbe"},{"key":"key-10.3201\/eid2303.161499-201702140826-R16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004682","article-title":"Characterization of lethal Zika virus infection in AG129 mice.","volume":"10","author":"Aliota","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R17","doi-asserted-by":"publisher","first-page":"16595","DOI":"10.1073\/pnas.1010494107","article-title":"Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.","volume":"107","author":"Pulvers","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2303.161499-201702140826-R18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.15585\/mmwr.mm6506e1","article-title":"Notes from the Field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses\u2014Brazil, 2015.","volume":"65","author":"Martines","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2303.161499-201702140826-R19","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/S0140-6736(16)30883-2","article-title":"Pathology of congenital Zika syndrome in Brazil: a case series.","volume":"388","author":"Martines","year":"2016","journal-title":"Lancet"},{"key":"key-10.3201\/eid2303.161499-201702140826-R20","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly.","volume":"374","author":"Mlakar","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2303.161499-201702140826-R21","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities.","volume":"374","author":"Driggers","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2303.161499-201702140826-R22","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1056\/NEJMra1213566","article-title":"Pregnancy and infection.","volume":"370","author":"Kourtis","year":"2014","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2303.161499-201702140826-R23","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007.","volume":"14","author":"Lanciotti","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R24","doi-asserted-by":"publisher","first-page":"pii:e20160621.","DOI":"10.1542\/peds.2016-0621","article-title":"Zika virus disease: a CDC update for pediatric health care providers.","volume":"137","author":"Karwowski","year":"2016","journal-title":"Pediatrics"},{"key":"key-10.3201\/eid2303.161499-201702140826-R25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.15585\/mmwr.mm6521e1","article-title":"Interim guidance for interpretation of Zika virus antibody test results.","volume":"65","author":"Rabe","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2303.161499-201702140826-R26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.4269\/ajtmh.2012.11-0346","article-title":"Molecular detection and typing of dengue viruses from archived tissues of fatal cases by rt-PCR and sequencing: diagnostic and epidemiologic implications.","volume":"86","author":"Bhatnagar","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid2303.161499-201702140826-R27","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1128\/JCM.39.11.4119-4124.2001","article-title":"Development and evaluation of serotype- and group-specific fluorogenic reverse transcriptase PCR (TaqMan) assays for dengue virus.","volume":"39","author":"Callahan","year":"2001","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2303.161499-201702140826-R28","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3201\/eid1305.070015","article-title":"Chikungunya virus in US travelers returning from India, 2006.","volume":"13","author":"Lanciotti","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.7883\/yoken.63.67","article-title":"The first autopsy case of pandemic influenza (A\/H1N1pdm) virus infection in Japan: detection of a high copy number of the virus in type II alveolar epithelial cells by pathological and virological examination.","volume":"63","author":"Nakajima","year":"2010","journal-title":"Jpn J Infect Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues.","volume":"14","author":"Wang","year":"2012","journal-title":"J Mol Diagn"},{"key":"key-10.3201\/eid2303.161499-201702140826-R31","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","article-title":"Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells.","volume":"18","author":"Nowakowski","year":"2016","journal-title":"Cell Stem Cell"},{"key":"key-10.3201\/eid2303.161499-201702140826-R32","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ebiom.2015.11.050","article-title":"Immunolocalization and distribution of rubella antigen in fatal congenital rubella syndrome.","volume":"3","author":"Lazar","year":"2015","journal-title":"EBioMedicine"},{"key":"key-10.3201\/eid2303.161499-201702140826-R33","doi-asserted-by":"crossref","unstructured":"Ritter JM, Martines RB, Zaki SR. Zika virus: pathology from the pandemic. Arch Pathol Lab Med. 2016 Oct 5 [Epub ahead of print].","DOI":"10.5858\/arpa.2016-0397-SA"},{"key":"key-10.3201\/eid2303.161499-201702140826-R34","doi-asserted-by":"publisher","first-page":"S830","DOI":"10.1093\/clinids\/11.Supplement_4.S830","article-title":"Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade.","volume":"11","author":"Halstead","year":"1989","journal-title":"Rev Infect Dis"},{"key":"key-10.3201\/eid2303.161499-201702140826-R35","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1128\/JCM.03239-12","article-title":"Persistent intraocular rubella infection in a patient with Fuchs\u2019 uveitis and congenital rubella syndrome.","volume":"51","author":"Winchester","year":"2013","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2303.161499-201702140826-R36","first-page":"813","article-title":"The ocular manifestations of congenital infection: a study of the early effect and long-term outcome of maternally transmitted rubella and toxoplasmosis.","volume":"96","author":"O\u2019Neill","year":"1998","journal-title":"Trans Am Ophthalmol Soc"},{"key":"key-10.3201\/eid2303.161499-201702140826-R37","doi-asserted-by":"publisher","first-page":"e10649","DOI":"10.1371\/journal.pone.0010649","article-title":"Persistence of West Nile virus in the central nervous system and periphery of mice.","volume":"5","author":"Appler","year":"2010","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2303.161499-201702140826-R38","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jcv.2006.11.003","article-title":"Detection of West Nile virus in formalin-fixed, paraffin-embedded human tissues by RT-PCR: a useful adjunct to conventional tissue-based diagnostic methods.","volume":"38","author":"Bhatnagar","year":"2007","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid2303.161499-201702140826-R39","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1172\/JCI40104","article-title":"Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages.","volume":"120","author":"Labadie","year":"2010","journal-title":"J Clin Invest"},{"key":"key-10.3201\/eid2303.161499-201702140826-R40","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1056\/NEJMc1607583","article-title":"Prolonged shedding of Zika virus associated with congenital infection.","volume":"375","author":"Oliveira","year":"2016","journal-title":"N Engl J Med"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/23\/3\/16-1499_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T23:31:03Z","timestamp":1732923063000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/23\/3\/16-1499_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2303.161499","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}