{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:23:08Z","timestamp":1790947388278,"version":"4.1.0"},"reference-count":41,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3201\/eid2305.151417","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T12:39:49Z","timestamp":1494592789000},"source":"Crossref","is-referenced-by-count":23,"title":["Increased Neurotropic Threat from <i>Burkholderia pseudomallei<\/i> Strains with a <i>B. mallei<\/i>\u2013like Variation in the <i>bimA<\/i> Motility Gene, Australia"],"prefix":"10.3201","volume":"23","author":[{"given":"Jodie L.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek S.","family":"Sarovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin P.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Govan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J.","family":"Currie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natkunam","family":"Ketheesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2305.151417-201705120839-R1","doi-asserted-by":"publisher","first-page":"14240","DOI":"10.1073\/pnas.0403302101","article-title":"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.","volume":"101","author":"Holden","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.3201\/eid2305.151417-201705120839-R2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fmicb.2012.00149","article-title":"Recent progress in melioidosis and glanders.","volume":"3","author":"Torres","year":"2012","journal-title":"Front Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R3","unstructured":"Ketheesan N. Melioidosis: a century of observation and research. Amsterdam: Elsevier Press; 2012."},{"key":"key-10.3201\/eid2305.151417-201705120839-R4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nrmicro1320","article-title":"Actin-dependent movement of bacterial pathogens.","volume":"4","author":"Stevens","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1365-2958.2004.04528.x","article-title":"Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei.","volume":"56","author":"Stevens","year":"2005","journal-title":"Mol Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R6","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1111\/j.1365-2958.2007.05734.x","article-title":"Type VI secretion is a major virulence determinant in Burkholderia mallei.","volume":"64","author":"Schell","year":"2007","journal-title":"Mol Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R7","doi-asserted-by":"publisher","first-page":"7857","DOI":"10.1128\/JB.187.22.7857-7862.2005","article-title":"Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant.","volume":"187","author":"Stevens","year":"2005","journal-title":"J Bacteriol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R8","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1093\/infdis\/jiq142","article-title":"Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis.","volume":"203","author":"Suwannasaen","year":"2011","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4269\/ajtmh.2011.11-0166","article-title":"Molecular characterization of clinical Burkholderia pseudomallei isolates from India.","volume":"85","author":"Mukhopadhyay","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid2305.151417-201705120839-R10","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1128\/JCM.00368-08","article-title":"Prevalence and sequence diversity of a factor required for actin-based motility in natural populations of Burkholderia species.","volume":"46","author":"Sitthidet","year":"2008","journal-title":"J Clin Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3201\/eid2101.131570","article-title":"Neurotropic threat characterization of Burkholderia pseudomallei strains.","volume":"21","author":"Morris","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R12","doi-asserted-by":"publisher","first-page":"e91682","DOI":"10.1371\/journal.pone.0091682","article-title":"Variable virulence factors in Burkholderia pseudomallei (melioidosis) associated with human disease.","volume":"9","author":"Sarovich","year":"2014","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2305.151417-201705120839-R13","doi-asserted-by":"publisher","first-page":"e900","DOI":"10.1371\/journal.pntd.0000900","article-title":"The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study.","volume":"4","author":"Currie","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R14","first-page":"195","article-title":"The neuropathology of melioidosis: two cases and a review of the literature.","volume":"23","author":"Koszyca","year":"2004","journal-title":"Clin Neuropathol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R15","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S1286-4579(01)01417-4","article-title":"Burkholderia pseudomallei virulence: definition, stability and association with clonality.","volume":"3","author":"Ulett","year":"2001","journal-title":"Microbes Infect"},{"key":"key-10.3201\/eid2305.151417-201705120839-R16","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3201\/eid1104.041051","article-title":"Route of infection in melioidosis.","volume":"11","author":"Barnes","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R17","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints.","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Hyg"},{"key":"key-10.3201\/eid2305.151417-201705120839-R18","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1128\/IAI.01880-14","article-title":"Migration of dendritic cells facilitates systemic dissemination of Burkholderia pseudomallei.","volume":"82","author":"Williams","year":"2014","journal-title":"Infect Immun"},{"key":"key-10.3201\/eid2305.151417-201705120839-R19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/sj.icb.7100084","article-title":"Development of protective immunity in a murine model of melioidosis is influenced by the source of Burkholderia pseudomallei antigens.","volume":"85","author":"Barnes","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1574-695X.2010.00767.x","article-title":"Impact of streptozotocin-induced diabetes on functional responses of dendritic cells and macrophages towards Burkholderia pseudomallei.","volume":"61","author":"Williams","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R21","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1006\/mpat.1997.0179","article-title":"BALB\/c and C57Bl\/6 mice infected with virulent Burkholderia pseudomallei provide contrasting animal models for the acute and chronic forms of human melioidosis.","volume":"24","author":"Leakey","year":"1998","journal-title":"Microb Pathog"},{"key":"key-10.3201\/eid2305.151417-201705120839-R22","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/j.1440-1754.2008.01410.x","article-title":"Paediatric melioidosis in North Queensland, Australia.","volume":"44","author":"Kandasamy","year":"2008","journal-title":"J Paediatr Child Health"},{"key":"key-10.3201\/eid2305.151417-201705120839-R23","doi-asserted-by":"publisher","first-page":"5377","DOI":"10.1128\/IAI.68.9.5377-5384.2000","article-title":"Burkholderia pseudomallei induces cell fusion and actin-associated membrane protrusion: a possible mechanism for cell-to-cell spreading.","volume":"68","author":"Kespichayawattana","year":"2000","journal-title":"Infect Immun"},{"key":"key-10.3201\/eid2305.151417-201705120839-R24","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1128\/JB.01455-10","article-title":"Identification of motifs of Burkholderia pseudomallei BimA required for intracellular motility, actin binding, and actin polymerization.","volume":"193","author":"Sitthidet","year":"2011","journal-title":"J Bacteriol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R25","doi-asserted-by":"publisher","first-page":"8325","DOI":"10.1128\/AEM.06507-11","article-title":"Ruminant rhombencephalitis-associated Listeria monocytogenes alleles linked to a multilocus variable-number tandem-repeat analysis complex.","volume":"77","author":"Balandyt\u00e9","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R26","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1128\/AEM.68.2.616-622.2002","article-title":"Expression of ActA, Ami, InlB, and listeriolysin O in Listeria monocytogenes of human and food origin.","volume":"68","author":"Jacquet","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R27","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1128\/IAI.00515-10","article-title":"Phylogenetic analysis of Chlamydia trachomatis Tarp and correlation with clinical phenotype.","volume":"78","author":"Lutter","year":"2010","journal-title":"Infect Immun"},{"key":"key-10.3201\/eid2305.151417-201705120839-R28","doi-asserted-by":"publisher","first-page":"e2363","DOI":"10.1371\/journal.pntd.0002363","article-title":"Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse.","volume":"7","author":"Liu","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R29","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fmicb.2011.00174","article-title":"In vivo bioluminescence imaging of Burkholderia mallei respiratory infection and treatment in the mouse model.","volume":"2","author":"Massey","year":"2011","journal-title":"Front Microbiol"},{"key":"key-10.3201\/eid2305.151417-201705120839-R30","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1086\/599210","article-title":"Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis.","volume":"199","author":"Owen","year":"2009","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R31","doi-asserted-by":"publisher","first-page":"e00025","DOI":"10.1128\/mBio.00025-14","article-title":"Burkholderia pseudomallei penetrates the brain via destruction of the olfactory and trigeminal nerves: implications for the pathogenesis of neurological melioidosis.","volume":"5","author":"St John","year":"2014","journal-title":"MBio"},{"key":"key-10.3201\/eid2305.151417-201705120839-R32","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1128\/IAI.00361-16","article-title":"Burkholderia pseuodomallei rapidly infects the brainstem and spinal cord via the trigeminal nerve after intranasal inoculation.","volume":"84","author":"St John","year":"2016","journal-title":"Infect Immun"},{"key":"key-10.3201\/eid2305.151417-201705120839-R33","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/S0035-9203(02)90248-8","article-title":"Cerebral melioidosis in Singapore: a review of five cases.","volume":"96","author":"Chadwick","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key-10.3201\/eid2305.151417-201705120839-R34","doi-asserted-by":"crossref","unstructured":"Lim RS, Flatman S, Dahm MC. Sinonasal melioidosis in a returned traveller presenting with nasal cellulitis and sinusitis. Case Rep Otolaryngol. 2013;2013:920352.","DOI":"10.1155\/2013\/920352"},{"key":"key-10.3201\/eid2305.151417-201705120839-R35","first-page":"862","article-title":"Uncommon clinical presentations of melioidosis in children: 2 cases with sore throat and 1 case with urticarial rash.","volume":"44","author":"Lumbiganon","year":"2013","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"key-10.3201\/eid2305.151417-201705120839-R36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1055\/s-0034-1398389","article-title":"Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment.","volume":"36","author":"Currie","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"key-10.3201\/eid2305.151417-201705120839-R37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/cid\/ciu733","article-title":"Clinical presentation and medical management of melioidosis in children: a 24-year prospective study in the Northern Territory of Australia and review of the literature.","volume":"60","author":"McLeod","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2305.151417-201705120839-R38","doi-asserted-by":"publisher","first-page":"e115951","DOI":"10.1371\/journal.pone.0115951","article-title":"Interrogation of the Burkholderia pseudomallei genome to address differential virulence among isolates.","volume":"9","author":"Challacombe","year":"2014","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2305.151417-201705120839-R39","doi-asserted-by":"publisher","first-page":"e0121052","DOI":"10.1371\/journal.pone.0121052","article-title":"Genomic characterization of Burkholderia pseudomallei isolates selected for medical countermeasures testing: comparative genomics associated with differential virulence.","volume":"10","author":"Sahl","year":"2015","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2305.151417-201705120839-R40","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S1286-4579(01)01417-4","article-title":"Burkholderia pseudomallei virulence: definition, stability and association with clonality.","volume":"3","author":"Ulett","year":"2001","journal-title":"Microbes Infect"},{"key":"key-10.3201\/eid2305.151417-201705120839-R41","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1574-6968.2007.00946.x","article-title":"Virulence of clinical and environmental isolates of Burkholderia oklahomensis and Burkholderia thailandensis in hamsters and mice.","volume":"277","author":"Deshazer","year":"2007","journal-title":"FEMS Microbiol Lett"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/23\/5\/15-1417_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T23:31:34Z","timestamp":1732923094000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/23\/5\/15-1417_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2305.151417","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}