{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:07:11Z","timestamp":1784074031843,"version":"3.55.0"},"reference-count":48,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.3201\/eid2308.170029","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T14:09:30Z","timestamp":1498486170000},"page":"1316-1324","source":"Crossref","is-referenced-by-count":15,"title":["Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates"],"prefix":"10.3201","volume":"23","author":[{"given":"Ronald B.","family":"Reisler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Donofrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis K.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay B.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly S.","family":"Stuthman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.","family":"Vantongeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger C.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Kortepeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Cardile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2308.170029-201707141250-R1","unstructured":"Centers for Disease Control and Prevention. 2014 Ebola outbreak in West Africa\u2014case counts [cited 2016 Dec 5]. https:\/\/www.cdc.gov\/vhf\/ebola\/outbreaks\/2014-west-africa\/case-counts.html"},{"key":"key-10.3201\/eid2308.170029-201707141250-R2","doi-asserted-by":"publisher","first-page":"S810","DOI":"10.1093\/infdis\/jir299","article-title":"Basic clinical and laboratory features of filoviral hemorrhagic fever.","volume":"204","author":"Kortepeter","year":"2011","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R3","doi-asserted-by":"publisher","first-page":"e1001908","DOI":"10.1371\/journal.pmed.1001908","article-title":"Use of viremia to evaluate the baseline case fatality ratio of Ebola virus disease and inform treatment studies: a retrospective cohort study.","volume":"12","author":"Faye","year":"2015","journal-title":"PLoS Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R4","doi-asserted-by":"publisher","first-page":"4330","DOI":"10.1128\/JVI.78.8.4330-4341.2004","article-title":"Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome.","volume":"78","author":"Towner","year":"2004","journal-title":"J Virol"},{"key":"key-10.3201\/eid2308.170029-201707141250-R5","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1056\/NEJMoa1411680","article-title":"Clinical illness and outcomes in patients with Ebola in Sierra Leone.","volume":"371","author":"Schieffelin","year":"2014","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R6","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1172\/JCI83162","article-title":"Ebola viral load at diagnosis associates with patient outcome and outbreak evolution.","volume":"125","author":"de La Vega","year":"2015","journal-title":"J Clin Invest"},{"key":"key-10.3201\/eid2308.170029-201707141250-R7","doi-asserted-by":"publisher","first-page":"4692","DOI":"10.1172\/JCI83111","article-title":"Blood kinetics of Ebola virus in survivors and nonsurvivors.","volume":"125","author":"Lanini","year":"2015","journal-title":"J Clin Invest"},{"key":"key-10.3201\/eid2308.170029-201707141250-R8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3201\/eid2202.151250","article-title":"Prognostic indicators for Ebola patient survival.","volume":"22","author":"Crowe","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R9","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1093\/infdis\/jiv304","article-title":"The contribution of Ebola viral load at admission and other patient characteristics to mortality in a M\u00e9decins Sans Fronti\u00e8res Ebola case management centre, Kailahun, Sierra Leone, June\u2013October 2014.","volume":"212","author":"Fitzpatrick","year":"2015","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R10","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/S1473-3099(15)00144-9","article-title":"Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study.","volume":"15","author":"Hunt","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R11","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/infdis\/jiv546","article-title":"Monitoring of prognostic laboratory markers in Ebola virus disease.","volume":"213","author":"Janvier","year":"2016","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R12","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.3201\/eid2209.151621","article-title":"Clinical features of and risk factors for fatal Ebola virus disease, Moyamba District, Sierra Leone, December 2014\u2013February 2015.","volume":"22","author":"Haaskjold","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R13","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.ajic.2016.04.216","article-title":"Epidemiologic characteristics, clinical manifestations, and risk factors of 139 patients with Ebola virus disease in western Sierra Leone.","volume":"44","author":"Xu","year":"2016","journal-title":"Am J Infect Control"},{"key":"key-10.3201\/eid2308.170029-201707141250-R14","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1017\/S0950268815003003","article-title":"Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015.","volume":"144","author":"Wong","year":"2016","journal-title":"Epidemiol Infect"},{"key":"key-10.3201\/eid2308.170029-201707141250-R15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/cid\/civ319","article-title":"Clinical features of patients with Ebola virus disease in Sierra Leone.","volume":"61","author":"Qin","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R16","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1086\/514311","article-title":"Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival.","volume":"179","author":"Sadek","year":"1999","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1056\/NEJMc1510305","article-title":"Ebola virus disease among male and female persons in West Africa.","volume":"374","author":"Agua-Agum","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R18","doi-asserted-by":"publisher","first-page":"S364","DOI":"10.1086\/520613","article-title":"Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus.","volume":"196","author":"Rollin","year":"2007","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R19","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1093\/cid\/civ202","article-title":"Clinical predictors of mortality in patients with Ebola virus disease.","volume":"60","author":"Barry","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R20","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.medmal.2014.09.009","article-title":"Ebola outbreak in Conakry, Guinea: epidemiological, clinical, and outcome features.","volume":"44","author":"Barry","year":"2014","journal-title":"Med Mal Infect"},{"key":"key-10.3201\/eid2308.170029-201707141250-R21","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1089\/vim.2014.0085","article-title":"Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques.","volume":"28","author":"Martins","year":"2015","journal-title":"Viral Immunol"},{"key":"key-10.3201\/eid2308.170029-201707141250-R22","doi-asserted-by":"publisher","first-page":"4666","DOI":"10.3390\/v6114666","article-title":"Euthanasia assessment in ebola virus infected nonhuman primates.","volume":"6","author":"Warren","year":"2014","journal-title":"Viruses"},{"key":"key-10.3201\/eid2308.170029-201707141250-R23","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.3201\/eid2110.150259","article-title":"Delayed disease progression in cynomolgus macaques infected with Ebola virus Makona strain.","volume":"21","author":"Marzi","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R24","doi-asserted-by":"publisher","first-page":"S281","DOI":"10.1093\/infdis\/jiw267","article-title":"Pathogenicity comparison between the Kikwit and Makona Ebola virus variants in rhesus macaques.","volume":"214","author":"Wong","year":"2016","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R25","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.2217\/bmm.14.75","article-title":"Biomarkers for understanding Ebola virus disease.","volume":"8","author":"McElroy","year":"2014","journal-title":"Biomarkers Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R26","doi-asserted-by":"publisher","first-page":"S188","DOI":"10.1086\/514283","article-title":"Markedly elevated levels of interferon (IFN)-\u03b3, IFN-\u03b1, interleukin (IL)-2, IL-10, and tumor necrosis factor-\u03b1 associated with fatal Ebola virus infection.","volume":"179","author":"Villinger","year":"1999","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<463::AID-JMV15>3.0.CO;2-M","article-title":"Diagnosis of Ebola haemorrhagic fever by RT-PCR in an epidemic setting.","volume":"60","author":"Leroy","year":"2000","journal-title":"J Med Virol"},{"key":"key-10.3201\/eid2308.170029-201707141250-R28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nature17180","article-title":"Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.","volume":"531","author":"Warren","year":"2016","journal-title":"Nature"},{"key":"key-10.3201\/eid2308.170029-201707141250-R29","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/S0140-6736(10)60357-1","article-title":"Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study.","volume":"375","author":"Geisbert","year":"2010","journal-title":"Lancet"},{"key":"key-10.3201\/eid2308.170029-201707141250-R30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"},{"key":"key-10.3201\/eid2308.170029-201707141250-R31","doi-asserted-by":"publisher","first-page":"199ra113","DOI":"10.1126\/scitranslmed.3006608","article-title":"Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail.","volume":"5","author":"Pettitt","year":"2013","journal-title":"Sci Transl Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R32","doi-asserted-by":"publisher","first-page":"e0004549","DOI":"10.1371\/journal.pntd.0004549","article-title":"Transforming clinical data into actionable prognosis models: machine-learning framework and field-deployable app to predict outcome of Ebola patients.","volume":"10","author":"Colubri","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jcv.2015.12.006","article-title":"Crucial parameter of the outcome in Crimean Congo hemorrhagic fever: Viral load.","volume":"75","author":"Hasanoglu","year":"2016","journal-title":"J Clin Virol"},{"key":"key-10.3201\/eid2308.170029-201707141250-R34","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1016\/j.ijid.2011.06.005","article-title":"Evaluation of factors predictive of the prognosis in Crimean-Congo hemorrhagic fever: new suggestions.","volume":"16","author":"Ozturk","year":"2012","journal-title":"Int J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R35","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1093\/infdis\/jis472","article-title":"Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients.","volume":"206","author":"Gai","year":"2012","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R36","first-page":"S220","article-title":"Serum lactate and lactate dehydrogenase as parameters for the prediction of dengue severity.","volume":"97","author":"Sirikutt","year":"2014","journal-title":"J Med Assoc Thai"},{"key":"key-10.3201\/eid2308.170029-201707141250-R37","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.mito.2014.05.007","article-title":"Comprehensive review on lactate metabolism in human health.","volume":"17","author":"Adeva-Andany","year":"2014","journal-title":"Mitochondrion"},{"key":"key-10.3201\/eid2308.170029-201707141250-R38","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.6061\/clinics\/2013(07)23","article-title":"Temporal relationship of serum markers and tissue damage during acute intestinal ischemia\/reperfusion.","volume":"68","author":"Guzm\u00e1n-de la Garza","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"key-10.3201\/eid2308.170029-201707141250-R39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12328-014-0540-0","article-title":"Intestinal necrosis due to norovirus enteritis.","volume":"8","author":"Yasuda","year":"2015","journal-title":"Clin J Gastroenterol"},{"key":"key-10.3201\/eid2308.170029-201707141250-R40","doi-asserted-by":"publisher","first-page":"620","DOI":"10.7196\/SAMJ.5150","article-title":"Clinical neonatal rotavirus infection: association with necrotising enterocolitis.","volume":"102","author":"de Villiers","year":"2012","journal-title":"S Afr Med J"},{"key":"key-10.3201\/eid2308.170029-201707141250-R41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13037-014-0048-z","article-title":"Combined endothelial and epithelial barrier disruption of the colon may be a contributing factor to the Ebola sepsis-like syndrome.","volume":"9","author":"Lynn","year":"2015","journal-title":"Patient Saf Surg"},{"key":"key-10.3201\/eid2308.170029-201707141250-R42","doi-asserted-by":"publisher","first-page":"S1000","DOI":"10.1093\/infdis\/jir337","article-title":"Real-time monitoring of cardiovascular function in rhesus macaques infected with Zaire ebolavirus.","volume":"204","author":"Kortepeter","year":"2011","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2308.170029-201707141250-R43","doi-asserted-by":"crossref","unstructured":"Zein JG, Lee GL, Tawk M, Dabaja M, Kinasewitz GT. Prognostic significance of elevated serum lactate dehydrogenase (LDH) in patients with severe sepsis. Chest. 2004;126(4_Meeting Abstracts):873S. 10.1378\/chest.126.4_MeetingAbstracts.873S","DOI":"10.1378\/chest.126.4_MeetingAbstracts.873S"},{"key":"key-10.3201\/eid2308.170029-201707141250-R44","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1757-7241-19-74","article-title":"Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review.","volume":"19","author":"Kruse","year":"2011","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13054-016-1403-5","article-title":"The value of blood lactate kinetics in critically ill patients: a systematic review.","volume":"20","author":"Vincent","year":"2016","journal-title":"Crit Care"},{"key":"key-10.3201\/eid2308.170029-201707141250-R46","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.ajem.2016.06.012","article-title":"Prognostic value of neglected biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase.","volume":"34","author":"Duman","year":"2016","journal-title":"Am J Emerg Med"},{"key":"key-10.3201\/eid2308.170029-201707141250-R47","first-page":"439","article-title":"Diagnostic and prognostic value of very high serum lactate dehydrogenase in admitted medical patients.","volume":"16","author":"Erez","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"key-10.3201\/eid2308.170029-201707141250-R48","first-page":"227","article-title":"Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus.","volume":"76","author":"Johnson","year":"1995","journal-title":"Int J Exp Pathol"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/23\/8\/17-0029_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T23:32:48Z","timestamp":1732923168000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/23\/8\/17-0029_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2308.170029","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}