{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:58:17Z","timestamp":1774025897597,"version":"3.50.1"},"reference-count":28,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.3201\/eid2408.171004","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T12:00:00Z","timestamp":1529668800000},"page":"1435-1443","source":"Crossref","is-referenced-by-count":15,"title":["Hypoglycemic Toxins and Enteroviruses as Causes of Outbreaks of Acute Encephalitis-Like Syndrome in Children, Bac Giang Province, Northern Vietnam"],"prefix":"10.3201","volume":"24","author":[{"given":"Nga Thi","family":"Phan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriadeg Ar","family":"Gouilh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Paireau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loan","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Cheval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nghia Duy","family":"Ngu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan Hai","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tondeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Manuguerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Barouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Sander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien Tran","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Brey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Fontanet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Eloit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2408.171004-201807160950-R1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1743-422X-5-134","article-title":"The incidence of acute encephalitis syndrome in Western industrialised and tropical countries.","volume":"5","author":"Jmor","year":"2008","journal-title":"Virol J"},{"key":"key-10.3201\/eid2408.171004-201807160950-R2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pneurobio.2009.12.003","article-title":"Emergence and re-emergence of viral diseases of the central nervous system.","volume":"91","author":"Griffin","year":"2010","journal-title":"Prog Neurobiol"},{"key":"key-10.3201\/eid2408.171004-201807160950-R3","doi-asserted-by":"publisher","first-page":"e854","DOI":"10.1371\/journal.pntd.0000854","article-title":"Viral etiology of encephalitis in children in southern Vietnam: results of a one-year prospective descriptive study.","volume":"4","author":"Le","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2408.171004-201807160950-R4","doi-asserted-by":"publisher","first-page":"e2383","DOI":"10.1371\/journal.pntd.0002383","article-title":"The functional, social and economic impact of acute encephalitis syndrome in Nepal\u2014a longitudinal follow-up study.","volume":"7","author":"Griffiths","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2408.171004-201807160950-R5","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1017\/S0950268813003397","article-title":"Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India.","volume":"142","author":"Rathore","year":"2014","journal-title":"Epidemiol Infect"},{"key":"key-10.3201\/eid2408.171004-201807160950-R6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3201\/eid0601.000103","article-title":"Japanese encephalitis immunization in South Korea: past, present, and future.","volume":"6","author":"Sohn","year":"2000","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2408.171004-201807160950-R7","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJMp058263","article-title":"Control of Japanese encephalitis\u2014within our grasp?","volume":"355","author":"Solomon","year":"2006","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2408.171004-201807160950-R8","doi-asserted-by":"publisher","first-page":"e624","DOI":"10.1371\/journal.pntd.0000624","article-title":"The neglected arboviral infections in mainland China.","volume":"4","author":"Gao","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"key-10.3201\/eid2408.171004-201807160950-R9","doi-asserted-by":"publisher","first-page":"344","DOI":"10.4269\/ajtmh.2010.09-0125","article-title":"Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005.","volume":"82","author":"Hossain","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid2408.171004-201807160950-R10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.4269\/ajtmh.12-0436","article-title":"Dengue virus and Japanese encephalitis virus epidemiological shifts in Nepal: a case of opposing trends.","volume":"88","author":"Dumre","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"key-10.3201\/eid2408.171004-201807160950-R11","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.3201\/eid1811.111761","article-title":"Litchi-associated acute encephalitis in children, Northern Vietnam, 2004-2009.","volume":"18","author":"Paireau","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2408.171004-201807160950-R12","first-page":"570","article-title":"Recurrent outbreaks of hypoglycaemic encephalopathy in Muzaffarpur, Bihar.","volume":"107","author":"Shah","year":"2014","journal-title":"Curr Sci"},{"key":"key-10.3201\/eid2408.171004-201807160950-R13","first-page":"1184","article-title":"Acute encephalitis syndrome in children in Muzaffarpur: hypothesis of toxic origin.","volume":"106","author":"John","year":"2014","journal-title":"Curr Sci"},{"key":"key-10.3201\/eid2408.171004-201807160950-R14","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3201\/2105.141650","article-title":"Probable toxic cause for suspected lychee-linked viral encephalitis.","volume":"21","author":"Spencer","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2408.171004-201807160950-R15","first-page":"49","article-title":"Outbreaks of unexplained neurologic illness - Muzaffarpur, India, 2013-2014.","volume":"64","author":"Shrivastava","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.3201\/eid2408.171004-201807160950-R16","unstructured":"Islam S. Outbreak of illness and deaths among children living near lychee orchards in northern Bangladesh. ICDDR,B Health and Science Bulletin. 2012;10:15\u201325."},{"key":"key-10.3201\/eid2408.171004-201807160950-R17","first-page":"20195","article-title":"Litchi fruit contains methylene cyclopropyl-glycine.","volume":"109","author":"Das","year":"2015","journal-title":"Curr Sci"},{"key":"key-10.3201\/eid2408.171004-201807160950-R18","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.1021\/acs.jafc.6b02478","article-title":"Quantification of toxins in soapberry (Sapindaceae) arils: hypoglycin A and methylenecyclopropylglycine.","volume":"64","author":"Isenberg","year":"2016","journal-title":"J Agric Food Chem"},{"key":"key-10.3201\/eid2408.171004-201807160950-R19","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1042\/bj2740395","article-title":"Metabolic consequences of methylenecyclopropylglycine poisoning in rats.","volume":"274","author":"Melde","year":"1991","journal-title":"Biochem J"},{"key":"key-10.3201\/eid2408.171004-201807160950-R20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jchromb.2016.07.005","article-title":"Quantification of hypoglycin A as butyl ester.","volume":"1029-1030","author":"Sander","year":"2016","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key-10.3201\/eid2408.171004-201807160950-R21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/1040638715624736","article-title":"Rapid diagnosis of hypoglycin A intoxication in atypical myopathy of horses.","volume":"28","author":"Sander","year":"2016","journal-title":"J Vet Diagn Invest"},{"key":"key-10.3201\/eid2408.171004-201807160950-R22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1651-2227.1999.tb01156.x","article-title":"Laboratory integration and utilization of tandem mass spectrometry in neonatal screening: a model for clinical mass spectrometry in the next millennium.","volume":"88","author":"Chace","year":"1999","journal-title":"Acta Paediatr Suppl"},{"key":"key-10.3201\/eid2408.171004-201807160950-R23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0146-0005(99)80050-0","article-title":"Application of electrospray tandem mass spectrometry to neonatal screening.","volume":"23","author":"Rashed","year":"1999","journal-title":"Semin Perinatol"},{"key":"key-10.3201\/eid2408.171004-201807160950-R24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1056\/NEJM197608262950901","article-title":"Jamaican vomiting sickness. Biochemical investigation of two cases.","volume":"295","author":"Tanaka","year":"1976","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2408.171004-201807160950-R25","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(02)07681-X","article-title":"Viral encephalitis: familiar infections and emerging pathogens.","volume":"359","author":"Whitley","year":"2002","journal-title":"Lancet"},{"key":"key-10.3201\/eid2408.171004-201807160950-R26","doi-asserted-by":"publisher","first-page":"e458","DOI":"10.1016\/S2214-109X(17)30035-9","article-title":"Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study.","volume":"5","author":"Shrivastava","year":"2017","journal-title":"Lancet Glob Health"},{"key":"key-10.3201\/eid2408.171004-201807160950-R27","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1016\/S2214-109X(17)30046-3","article-title":"The enigma of litchi toxicity: an emerging health concern in southern Asia.","volume":"5","author":"Spencer","year":"2017","journal-title":"Lancet Glob Health"},{"key":"key-10.3201\/eid2408.171004-201807160950-R28","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1021\/acs.chemrestox.5b00205","article-title":"Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine.","volume":"28","author":"Isenberg","year":"2015","journal-title":"Chem Res Toxicol"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/24\/8\/17-1004_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T07:55:33Z","timestamp":1751702133000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/24\/8\/17-1004_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2408.171004","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}