{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:26:34Z","timestamp":1790303194379,"version":"4.1.0"},"reference-count":50,"publisher":"Centers for Disease Control and Prevention (CDC)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emerg. Infect. Dis."],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.3201\/eid2508.190113","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T18:17:26Z","timestamp":1557512246000},"page":"1485-1493","source":"Crossref","is-referenced-by-count":68,"title":["Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil"],"prefix":"10.3201","volume":"25","author":[{"given":"Celia","family":"Pedroso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel","family":"Sarno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Luz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Moreira-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Martins","family":"Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Brites","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate M.","family":"K\u00fcmmerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Felix","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1822","reference":[{"key":"key-10.3201\/eid2508.190113-201907121606-R1","doi-asserted-by":"publisher","first-page":"e01390","DOI":"10.1128\/mBio.01390-17","article-title":"High Zika virus seroprevalence in Salvador, northeastern Brazil limits the potential for further outbreaks.","volume":"8","author":"Netto","year":"2017","journal-title":"MBio"},{"key":"key-10.3201\/eid2508.190113-201907121606-R2","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro.","volume":"375","author":"Brasil","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2508.190113-201907121606-R3","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","article-title":"Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation.","volume":"388","author":"Fran\u00e7a","year":"2016","journal-title":"Lancet"},{"key":"key-10.3201\/eid2508.190113-201907121606-R4","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0140-6736(17)31368-5","article-title":"Infection-related microcephaly after the 2015 and 2016 Zika virus outbreaks in Brazil: a surveillance-based analysis.","volume":"390","author":"de Oliveira","year":"2017","journal-title":"Lancet"},{"key":"key-10.3201\/eid2508.190113-201907121606-R5","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/S1473-3099(17)30727-2","article-title":"Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study.","volume":"18","author":"de Ara\u00fajo","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models.","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"key-10.3201\/eid2508.190113-201907121606-R7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1056\/NEJMc1605389","article-title":"Requests for abortion in Latin America related to concern about Zika virus exposure.","volume":"375","author":"Aiken","year":"2016","journal-title":"N Engl J Med"},{"key":"key-10.3201\/eid2508.190113-201907121606-R8","doi-asserted-by":"publisher","first-page":"i3492","DOI":"10.1136\/bmj.i3492","article-title":"Abortion requests increase in Latin America after Zika warning, figures show.","volume":"353","author":"Mayor","year":"2016","journal-title":"BMJ"},{"key":"key-10.3201\/eid2508.190113-201907121606-R9","doi-asserted-by":"publisher","first-page":"e0201452","DOI":"10.1371\/journal.pone.0201452","article-title":"Zika might not be acting alone: Using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil.","volume":"13","author":"Campos","year":"2018","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2508.190113-201907121606-R10","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nature22401","article-title":"Establishment and cryptic transmission of Zika virus in Brazil and the Americas.","volume":"546","author":"Faria","year":"2017","journal-title":"Nature"},{"key":"key-10.3201\/eid2508.190113-201907121606-R11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41426-018-0082-5","article-title":"Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia.","volume":"7","author":"Pettersson","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R12","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature.2016.20309","article-title":"Brazil asks whether Zika acts alone to cause birth defects.","volume":"535","author":"Butler","year":"2016","journal-title":"Nature"},{"key":"key-10.3201\/eid2508.190113-201907121606-R13","doi-asserted-by":"publisher","first-page":"e00278","DOI":"10.1128\/mSphere.00278-18","article-title":"Exhaustive TORCH pathogen diagnostics corroborate Zika virus etiology of congenital malformations in northeastern Brazil.","volume":"3","author":"Moreira-Soto","year":"2018","journal-title":"MSphere"},{"key":"key-10.3201\/eid2508.190113-201907121606-R14","doi-asserted-by":"publisher","first-page":"e0117849","DOI":"10.1371\/journal.pone.0117849","article-title":"New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences.","volume":"10","author":"Moureau","year":"2015","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2508.190113-201907121606-R15","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans.","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"key-10.3201\/eid2508.190113-201907121606-R16","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S1473-3099(10)70166-3","article-title":"Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes.","volume":"10","author":"Halstead","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R17","doi-asserted-by":"publisher","first-page":"e0200478","DOI":"10.1371\/journal.pone.0200478","article-title":"Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors.","volume":"13","author":"Li","year":"2018","journal-title":"PLoS One"},{"key":"key-10.3201\/eid2508.190113-201907121606-R18","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41426-018-0199-6","article-title":"Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro.","volume":"7","author":"Hermanns","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity.","volume":"356","author":"Bardina","year":"2017","journal-title":"Science"},{"key":"key-10.3201\/eid2508.190113-201907121606-R20","first-page":"781","article-title":"Dengue virus-specific antibodies enhance Brazilian Zika virus infection.","volume":"215","author":"Castanha","year":"2017","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R21","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1038\/emi.2017.42","article-title":"Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology.","volume":"6","author":"Priyamvada","year":"2017","journal-title":"Emerg Microbes Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R22","doi-asserted-by":"publisher","first-page":"15674","DOI":"10.1038\/ncomms15674","article-title":"Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus.","volume":"8","author":"Pantoja","year":"2017","journal-title":"Nat Commun"},{"key":"key-10.3201\/eid2508.190113-201907121606-R23","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1093\/cid\/cix558","article-title":"Viral load and cytokine response profile does not support antibody-dependent enhancement in dengue-primed Zika virus-infected patients.","volume":"65","author":"Terzian","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R24","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians.","volume":"171","author":"Moore","year":"2017","journal-title":"JAMA Pediatr"},{"key":"key-10.3201\/eid2508.190113-201907121606-R25","doi-asserted-by":"publisher","first-page":"330ra36","DOI":"10.1126\/scitranslmed.aaf1517","article-title":"The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model.","volume":"8","author":"Kirkpatrick","year":"2016","journal-title":"Sci Transl Med"},{"key":"key-10.3201\/eid2508.190113-201907121606-R26","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets.","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol Biol Evol"},{"key":"key-10.3201\/eid2508.190113-201907121606-R27","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1177\/003335490912400320","article-title":"OpenEpi: a web-based epidemiologic and statistical calculator for public health.","volume":"124","author":"Sullivan","year":"2009","journal-title":"Public Health Rep"},{"key":"key-10.3201\/eid2508.190113-201907121606-R28","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1590\/S1020-49891997000100023","article-title":"The feasibility of eradicating Aedes aegypti in the Americas.","volume":"1","author":"Pan American Health Organization","year":"1997","journal-title":"Rev Panam Salud Publica"},{"key":"key-10.3201\/eid2508.190113-201907121606-R29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1590\/S0074-02761986000200019","article-title":"An outbreak of dengue virus at Rio de Janeiro\u20141986.","volume":"81","author":"Schatzmayr","year":"1986","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"key-10.3201\/eid2508.190113-201907121606-R30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1017\/S0950268800056788","article-title":"Dengue epidemic in the stage of Rio de Janeiro, Brazil, 1990-1: co-circulation of dengue 1 and dengue 2 serotypes.","volume":"111","author":"Nogueira","year":"1993","journal-title":"Epidemiol Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R31","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1590\/S0074-02762001000700007","article-title":"Dengue virus type 3 in Rio de Janeiro, Brazil.","volume":"96","author":"Nogueira","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"key-10.3201\/eid2508.190113-201907121606-R32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3201\/eid1404.071185","article-title":"Dengue virus type 4, Manaus, Brazil.","volume":"14","author":"Figueiredo","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R33","doi-asserted-by":"publisher","first-page":"E163","DOI":"10.1111\/1469-0691.12104","article-title":"Molecular characterization of dengue virus 1 from autochthonous dengue fever cases in Croatia.","volume":"19","author":"Kurolt","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R34","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1093\/infdis\/jix539","article-title":"Evidence for congenital Zika virus infection from neutralizing antibody titers in maternal sera, northeastern Brazil.","volume":"216","author":"Moreira-Soto","year":"2017","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R35","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1016\/S2214-109X(17)30496-5","article-title":"Does immunity after Zika virus infection cross-protect against dengue?","volume":"6","author":"Ribeiro","year":"2018","journal-title":"Lancet Glob Health"},{"key":"key-10.3201\/eid2508.190113-201907121606-R36","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1126\/science.aav6618","article-title":"Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.","volume":"363","author":"Rodriguez-Barraquer","year":"2019","journal-title":"Science"},{"key":"key-10.3201\/eid2508.190113-201907121606-R37","doi-asserted-by":"publisher","first-page":"e1002726","DOI":"10.1371\/journal.pmed.1002726","article-title":"Prior dengue virus infection and risk of Zika: A pediatric cohort in Nicaragua.","volume":"16","author":"Gordon","year":"2019","journal-title":"PLoS Med"},{"key":"key-10.3201\/eid2508.190113-201907121606-R38","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/infdis\/jit273","article-title":"Reduced risk of disease during postsecondary dengue virus infections.","volume":"208","author":"Olkowski","year":"2013","journal-title":"J Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R39","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41426-018-0168-0","article-title":"Dengue virus and the host innate immune response.","volume":"7","author":"Uno","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R40","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s13071-018-2830-8","article-title":"History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review.","volume":"11","author":"Salles","year":"2018","journal-title":"Parasit Vectors"},{"key":"key-10.3201\/eid2508.190113-201907121606-R41","doi-asserted-by":"publisher","first-page":"17082","DOI":"10.1038\/nmicrobiol.2017.82","article-title":"Host response: Cross-fit T cells battle Zika virus.","volume":"2","author":"Collins","year":"2017","journal-title":"Nat Microbiol"},{"key":"key-10.3201\/eid2508.190113-201907121606-R42","doi-asserted-by":"publisher","first-page":"e01469","DOI":"10.1128\/JVI.01469-17","article-title":"Prior dengue virus exposure shapes T cell immunity to Zika virus in humans.","volume":"91","author":"Grifoni","year":"2017","journal-title":"J Virol"},{"key":"key-10.3201\/eid2508.190113-201907121606-R43","doi-asserted-by":"publisher","first-page":"E480","DOI":"10.3390\/v10090480","article-title":"Improved immune responses against Zika virus after sequential dengue and Zika virus infection in humans.","volume":"10","author":"Delgado","year":"2018","journal-title":"Viruses"},{"key":"key-10.3201\/eid2508.190113-201907121606-R44","doi-asserted-by":"crossref","unstructured":"Saron WAA, Rathore APS, Ting L, Ooi EE, Low J, Abraham SN,  Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells. Sci Adv. 2018;4:eaar4297. PMID: 29978039","DOI":"10.1126\/sciadv.aar4297"},{"key":"key-10.3201\/eid2508.190113-201907121606-R45","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1038\/s41467-018-05458-0","article-title":"Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy.","volume":"9","author":"Regla-Nava","year":"2018","journal-title":"Nat Commun"},{"key":"key-10.3201\/eid2508.190113-201907121606-R46","doi-asserted-by":"publisher","first-page":"17036","DOI":"10.1038\/nmicrobiol.2017.36","article-title":"Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8+ T cells.","volume":"2","author":"Wen","year":"2017","journal-title":"Nat Microbiol"},{"key":"key-10.3201\/eid2508.190113-201907121606-R47","doi-asserted-by":"publisher","first-page":"1019.e1","DOI":"10.1016\/j.cmi.2018.01.026","article-title":"Evidence for multiple sylvatic transmission cycles during the 2016-2017 yellow fever virus outbreak, Brazil.","volume":"24","author":"Moreira-Soto","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"key-10.3201\/eid2508.190113-201907121606-R48","doi-asserted-by":"publisher","first-page":"e198","DOI":"10.1016\/j.ijid.2011.09.026","article-title":"Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001-2002.","volume":"16","author":"Guzman","year":"2012","journal-title":"Int J Infect Dis"},{"key":"key-10.3201\/eid2508.190113-201907121606-R49","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1016\/j.vaccine.2017.07.045","article-title":"Immune correlates of protection for dengue: State of the art and research agenda.","volume":"35","author":"Katzelnick","year":"2017","journal-title":"Vaccine"},{"key":"key-10.3201\/eid2508.190113-201907121606-R50","doi-asserted-by":"publisher","first-page":"114ra128","DOI":"10.1126\/scitranslmed.3003084","article-title":"Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity.","volume":"3","author":"OhAinle","year":"2011","journal-title":"Sci Transl Med"}],"container-title":["Emerging Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/wwwnc.cdc.gov\/eid\/article\/25\/8\/19-0113_article","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T17:29:48Z","timestamp":1732987788000},"score":1,"resource":{"primary":{"URL":"http:\/\/wwwnc.cdc.gov\/eid\/article\/25\/8\/19-0113_article.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"URL":"https:\/\/doi.org\/10.3201\/eid2508.190113","relation":{},"ISSN":["1080-6040","1080-6059"],"issn-type":[{"value":"1080-6040","type":"print"},{"value":"1080-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}